Results 21 to 30 of about 48,393 (270)

Cis and Trans Effects of Human Genomic Variants on Gene Expression [PDF]

, 2014
This work was funded by the Louis-Jeantet Foundation (http://www.jeantet.ch/), the European Research Council (Grant ID: 260927 http://erc.europa.eu/), the Swiss National Foundation (Grant ID: 130342 http://www.snf.ch), NCCR Frontiers In Genetics (http ...
A Boyd, AC Nica, AC Nica, AH Talukder, Alfonso Buil, AR Wood, AS Dimas, BE Stranger, BE Stranger, BU Schraml, C Wallace, Christopher David Brown, David M. Evans, DF Conrad, DJ Gaffney, DL Nicolae, DM Greenawalt, Donald F. Conrad, E Grundberg, E Klopocki, EE Schadt, Emmanouil T. Dermitzakis, George Davey Smith, GR Abecasis, H Huang, HJ Westra, J Ding, J Millstein, J Zhu, JD Storey, JE Powell, JK Pickrell, John P. Kemp, Julien Bryois, K Hildner, Karen M. Ho, LA Hindorff, M Gutierrez-Arcelus, M Scutari, Matthew Hurles, ND Miller, NL Barbosa-Morais, Panos Deloukas, RW Jones, SB Montgomery, SB Montgomery, SJ Loughran, Stephen B. Montgomery, Susan Ring, T Lappalainen, TR Insel, W Wang, Y Li, Y Li   +53 more
core   +22 more sources

Whole-organism eQTL mapping at cellular resolution with single-cell sequencing

eLife, 2021
Genetic regulation of gene expression underlies variation in disease risk and other complex traits. The effect of expression quantitative trait loci (eQTLs) varies across cell types; however, the complexity of mammalian tissues makes studying cell-type ...
Eyal Ben-David, James Boocock, Longhua Guo, Stefan Zdraljevic, Joshua S Bloom, Leonid Kruglyak   +5 more
doaj   +1 more source

eQTL regulates OsHAK5 in enhancing potassium content under salt stress in rice

Electronic Journal of Plant Breeding, 2023
To alleviate salt stress in rice, the role of potassium in countering the ill effects of sodium is gaining importance. Towards this, OsHAK5 a member of the high-affinity potassium transporter family was known for enhancing the intracellular potassium ...
Akshara Balachandra1, Varanavasiappan Shanmugam1, Kumar K. Krish1, Ravichandran Veerasamy2, Kokiladevi Easwaran1, Kaleeswari Ramaiah Kutralingam3, Sudhakar Duraialagaraja1, Arul Loganathan1*
doaj   +1 more source

Impact of natural genetic variation on gene expression dynamics. [PDF]

PLoS Genetics, 2013
DNA sequence variation causes changes in gene expression, which in turn has profound effects on cellular states. These variations affect tissue development and may ultimately lead to pathological phenotypes.
Marit Ackermann, Weronika Sikora-Wohlfeld, Andreas Beyer   +2 more
doaj   +1 more source

scQTLbase: an integrated human single-cell eQTL database

Nucleic Acids Research, 2023
Genome-wide association studies (GWAS) have identified numerous genetic variants associated with diseases and traits. However, the functional interpretation of these variants remains challenging.
Ruofan Ding, Qixuan Wang, Lihai Gong, Ting Zhang, Xudong Zou, Kewei Xiong, Qi Liao, Mireya Plass, Lei Li   +8 more
semanticscholar   +1 more source

Network Analysis Prioritizes DEWAX and ICE1 as the Candidate Genes for Major eQTL Hotspots in Seed Germination of Arabidopsis thaliana

G3: Genes, Genomes, Genetics, 2020
Seed germination is characterized by a constant change of gene expression across different time points. These changes are related to specific processes, which eventually determine the onset of seed germination.
Margi Hartanto, Ronny V. L. Joosen, Basten L. Snoek, Leo A. J. Willems, Mark G. Sterken, Dick de Ridder, Henk W. M. Hilhorst, Wilco Ligterink, Harm Nijveen   +8 more
doaj   +1 more source

Identification of asthma-related genes using asthmatic blood eQTLs of Korean patients

BMC Medical Genomics, 2023
Background More than 200 asthma-associated genetic variants have been identified in genome-wide association studies (GWASs). Expression quantitative trait loci (eQTL) data resources can help identify causal genes of the GWAS signals, but it can be ...
Dong Jun Kim, Ji Eun Lim, Hae-Un Jung, Ju Yeon Chung, Eun Ju Baek, Hyein Jung, Shin Young Kwon, Han Kyul Kim, Ji-One Kang, Kyungtaek Park, Sungho Won, Tae-Bum Kim, Bermseok Oh   +12 more
doaj   +1 more source

Expression quantitative trait locus studies in the era of single-cell omics

Frontiers in Genetics, 2023
Genome-wide association studies have revealed that the regulation of gene expression bridges genetic variants and complex phenotypes. Profiling of the bulk transcriptome coupled with linkage analysis (expression quantitative trait locus (eQTL) mapping ...
Jie Luo, Xinyi Wu, Yuan Cheng, Guang Chen, Jian Wang, Xijiao Song   +5 more
doaj   +1 more source

eQTL Catalogue 2023: New datasets, X chromosome QTLs, and improved detection and visualisation of transcript-level QTLs

PLoS Genetics, 2023
The eQTL Catalogue is an open database of uniformly processed human molecular quantitative trait loci (QTLs). We are continuously updating the resource to further increase its utility for interpreting genetic associations with complex traits.
N. Kerimov, Ralf Tambets, J. Hayhurst, Ida Rahu, P. Kolberg, Uku Raudvere, Ivan Kuzmin, Anshika Chowdhary, Andreas Vija, Hans J. Teras, M. Kanai, Jacob C. Ulirsch, M. Ryten, J. Hardy, S. Guelfi, D. Trabzuni, Sarah Kim-Hellmuth, W. Rayner, H. Finucane, Hedi Peterson, Abayomi Mosaku, Helen Parkinson, Kaur Alasoo   +22 more
semanticscholar   +1 more source

Meta-eQTL: a tool set for flexible eQTL meta-analysis [PDF]

BMC Bioinformatics, 2014
Increasing number of eQTL (Expression Quantitative Trait Loci) datasets facilitate genetics and systems biology research. Meta-analysis tools are in need to jointly analyze datasets of same or similar issue types to improve statistical power especially in trans-eQTL mapping. Meta-analysis framework is also necessary for ChrX eQTL discovery.We developed
Di Narzo, Antonio Fabio, Cheng, Haoxiang, Lu, Jianwei, Hao, Ke   +3 more
openaire   +2 more sources