Results 61 to 70 of about 41,400 (238)
Defense heterosis as a novel plant protection strategy: From theory to breeding practice
New Plant Protection, EarlyView.Defense heterosis, the enhanced disease resistance of hybrids compared to their parents, has evolved from early observations of hybrid vigor to a novel research concept. Advances are now clarifying its diverse genetic and molecular mechanisms across various plant–pathogen interactions.
Kaiqi Xu, Xue Li, Fangfang Li
wiley +1 more source
Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study. [PDF]
, 2015 Background/objectivesThe common non-coding single nucleotide polymorphism (SNP) rs3129882 in HLA-DRA is associated with risk for idiopathic Parkinson's disease (PD).
Boss, JM +11 more
core +2 more sources
VIEW, EarlyView.Prostate cancer, a leading cause of cancer in men globally, urgently requires improved diagnostic and treatment strategies. This study analyzed large genetic datasets and identified five key proteins (THBD, DST, IFI27L2, OSBPL10, PPP1R14A) that either increase or decrease cancer risk, while also exploring their roles in immune response and potential ...
Maoping Cai +11 more
wiley +1 more source
Data-driven assessment of eQTL mapping methods
BMC Genomics, 2010 Background The analysis of expression quantitative trait loci (eQTL) is a potentially powerful way to detect transcriptional regulatory relationships at the genomic scale.
Schughart Klaus +3 more
doaj +1 more source
Meta-analysis of massively parallel reporter assays enables prediction of regulatory function across cell types. [PDF]
, 2019 Deciphering the potential of noncoding loci to influence gene regulation has been the subject of intense research, with important implications in understanding genetic underpinnings of human diseases.
Ahituv, Nadav +3 more
core
Cancer Science, EarlyView.This study indicates that SPP1, as an important regulator of tumor progression, is upregulated in various tumors and has been associated with a poor prognosis. SPP1+M2 has a unique spatial location at the forefront of tumor invasion and metastasis, thereby promoting tumor progression. MARCO+M2, which forms a mutually exclusive relationship with SPP1+M2,
Xuan Luo +15 more
wiley +1 more source
PLoS ONE, 2019 BackgroundOf the 108 Schizophrenia (SZ) risk-loci discovered through genome-wide association studies (GWAS), 96 are not altering the sequence of any protein. Evidence linking non-coding risk-SNPs and genes may be established using expression quantitative
Jesper R Gådin +14 more
doaj +1 more source
BMC Genomics, 2010 Background Genetic analysis of transcriptional profiles is a promising approach for identifying and dissecting the genetics of complex traits like meat performance.
Schellander Karl +4 more
doaj +1 more source
Accurate modeling of confounding variation in eQTL studies leads to a great increase in power to detect trans-regulatory effects [PDF]
, 2011 Expression quantitative trait loci (eQTL) studies are an integral tool to investigate the genetic component of gene expression variation. A major challenge in the analysis of such studies are hidden confounding factors, such as unobserved covariates or ...
Neil Lawrence +2 more
core +1 more source
Genetic regulation of mouse liver metabolite levels. [PDF]
, 2014 We profiled and analyzed 283 metabolites representing eight major classes of molecules including Lipids, Carbohydrates, Amino Acids, Peptides, Xenobiotics, Vitamins and Cofactors, Energy Metabolism, and Nucleotides in mouse liver of 104 inbred and ...
Bennett, Brian J +11 more
core +1 more source