Results 71 to 80 of about 48,393 (270)

Genome-wide analyses for personality traits identify six genomic loci and show correlations with psychiatric disorders [PDF]

, 2016
Personality is influenced by genetic and environmental factors1 and associated with mental health. However, the underlying genetic determinants are largely unknown.
A Okbay, A Ramasamy, AE Poropat, Anders M Dale, Andrew Schork, B Bulik-Sullivan, B Devlin, B Franke, B Howie, BK Bulik-Sullivan, BM Henn, C Giambartolomei, CA Rietveld, Carol Franz, CG DeYoung, Chi-Hua Chen, Chun-Chieh Fan, CJ Soto, CJ Willer, D Falush, D Trabzuni, Daniel J Smith, David A Hinds, DF Gudbjartsson, DJ Smith, Dominic Holland, DP Hibar, DR Nyholt, E Green, G Bjornsdottir, Gyda Bjornsdottir, HC So, HN Kim, Hreinn Stefansson, J Van Os, J Yang, JA Gray, JH Barnett, JK Pickrell, JM Hettema, Joyce Y Tung, JR Gulcher, K Åberg, Kari Stefansson, Karolina Kauppi, KS Kendler, L Mezquita, Linda K McEvoy, LR Goldberg, MA Distel, MH de Moor, MH de Moor, Michael O'Donovan, Min-Tzu Lo, Nilotpal Sanyal, Olav B Smeland, Ole A Andreassen, P Bůžková, R Plomin, R Tabarés-Seisdedos, RA Power, RA Power, RJ Pruim, S Jakobwitz, S Purcell, S Ripke, SBG Eysenck, SL Karalunas, SM van den Berg, SM van den Berg, SR Browning, T Insel, T Vukasović, TA Greenwood, Thorgeir E Thorgeirsson, TJ Trull, V Boraska, Valentina Escott-Price, WK Thompson, Y Hu, Y Ono, Y Wang, Yunpeng Wang   +82 more
core   +3 more sources

Comparing allele specific expression and local expression quantitative trait loci and the influence of gene expression on complex trait variation in cattle

BMC Genomics, 2018
Background The mutations changing the expression level of a gene, or expression quantitative trait loci (eQTL), can be identified by testing the association between genetic variants and gene expression in multiple individuals (eQTL mapping), or by ...
Majid Khansefid, Jennie E. Pryce, Sunduimijid Bolormaa, Yizhou Chen, Catriona A. Millen, Amanda J. Chamberlain, Christy J. Vander Jagt, Michael E. Goddard   +7 more
doaj   +1 more source

A robust two‐sample transcriptome‐wide Mendelian randomization method integrating GWAS with multi‐tissue eQTL summary statistics

Genetic Epidemiology, 2021
By treating genetic variants as instrumental variables (IVs), two‐sample Mendelian randomization (MR) methods detect genetically regulated risk exposures for complex diseases using only summary statistics.
Kevin J. Gleason, Fan Yang, Lin S. Chen
semanticscholar   +1 more source

Immunosuppression causes dynamic changes in expression QTLs in psoriatic skin

Nature Communications, 2023
Psoriasis is a chronic, systemic inflammatory condition primarily affecting skin. While the role of the immune compartment (e.g., T cells) is well established, the changes in the skin compartment are more poorly understood.
Qian Xiao, Joseph Mears, Aparna Nathan, Kazuyoshi Ishigaki, Yuriy Baglaenko, Noha Lim, Laura A. Cooney, Kristina M. Harris, Mark S. Anderson, David A. Fox, Dawn E. Smilek, James G. Krueger, Soumya Raychaudhuri   +12 more
doaj   +1 more source

Unraveling the polygenic architecture of complex traits using blood eQTL metaanalysis

bioRxiv, 2018
Summary While many disease-associated variants have been identified through genome-wide association studies, their downstream molecular consequences remain unclear.
U. Võsa, A. Claringbould, H. Westra, M. Bonder, Patrick Deelen, B. Zeng, H. Kirsten, A. Saha, Roman Kreuzhuber, S. Kasela, N. Pervjakova, Isabel Alvaes, M. Favé, M. Agbessi, M. Christiansen, R. Jansen, I. Seppälä, L. Tong, A. Teumer, K. Schramm, G. Hemani, J. Verlouw, H. Yaghootkar, Reyhan Sonmez, Andrew Andrew, V. Kukushkina, A. Kalnapenkis, S. Rüeger, E. Porcu, J. Kronberg-Guzman, J. Kettunen, J. Powell, Bernett Lee, Futao Zhang, W. Arindrarto, F. Beutner, H. Brugge, Julia Dmitrieva, Mahmoud Elansary, B. P. Fairfax, M. Georges, B. Heijmans, M. Kähönen, Yungil Kim, J. Knight, P. Kovacs, K. Krohn, Shuang Li, M. Loeffler, U. Marigorta, Hailang Mei, Y. Momozawa, M. Müller-Nurasyid, M. Nauck, M. Nivard, B. Penninx, J. Pritchard, O. Raitakari, O. Rötzschke, E. Slagboom, C. Stehouwer, M. Stumvoll, P. Sullivan, P. Hoen, J. Thiery, A. Tönjes, J. Dongen, M. Iterson, J. Veldink, U. Völker, C. Wijmenga, M. Swertz, A. Andiappan, G. Montgomery, S. Ripatti, M. Perola, Z. Kutalik, E. Dermitzakis, S. Bergmann, T. Frayling, J. Meurs, H. Prokisch, H. Ahsan, B. Pierce, T. Lehtimäki, D. Boomsma, B. Psaty, Sina A. Gharib, P. Awadalla, L. Milani, W. Ouwehand, K. Downes, O. Stegle, A. Battle, Jian Yang, P. Visscher, M. Scholz, G. Gibson, T. Esko, L. Franke   +99 more
semanticscholar   +1 more source

An optimal variant to gene distance window derived from an empirical definition of cis and trans protein QTLs

BMC Bioinformatics, 2022
Background A genome-wide association study (GWAS) correlates variation in the genotype with variation in the phenotype across a cohort, but the causal gene mediating that impact is often unclear.
Eric B. Fauman, Craig Hyde
doaj   +1 more source

Novel Functional eQTL-SNPs Associated With Susceptibility to Mycoplasma pneumoniae Pneumonia in Children

Frontiers in Public Health, 2022
BackgroundThe functional causal single-nucleotide polymorphisms (SNPs) associated with susceptibility to Mycoplasma pneumoniae Pneumonia (MPP) have scarcely been identified.
Yang Dong, Yanmin Gao, Cheng Luo, Nengshun Wu, Zhounan Cheng, Anni Qiu, Yan Zhou, Wendi Zhang, Minjie Chu, Qing Chang   +9 more
doaj   +1 more source

Multi-omics Mendelian randomization integrating GWAS, eQTL and pQTL data revealed GSTM4 as a potential drug target for migraine

The Journal of Headache and Pain
Introduction Migraine, as a complex neurological disease, brings heavy burden to patients and society. Despite the availability of established therapies, existing medications have limited efficacy. Thus, we aimed to find the drug targets that improve the
Xinyue Sun, Bohong Chen, Yi Qi, M. Wei, Wanying Chen, Xiaoyu Wu, Qingfan Wang, Jiahao Li, Xiangyu Lei, Guogang Luo   +9 more
semanticscholar   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Trans-eQTL mapping in gene sets identifies network effects of genetic variants

bioRxiv
Nearly all trait-associated variants identified in GWAS are non-coding. The cis regulatory effects of these variants have been extensively characterized, but how they impact gene regulation in trans has been the subject of much fewer studies.
Lili Wang, Nikita Babushkin, Zhonghua Liu, Xuanyao Liu   +3 more
semanticscholar   +1 more source