Results 61 to 70 of about 48,393 (270)
Topological Analysis of Metabolic Networks Integrating Co-Segregating Transcriptomes and Metabolomes in Type 2 Diabetic Rat Congenic Series [PDF]
, 2016 Background: The genetic regulation of metabolic phenotypes (i.e., metabotypes) in type 2 diabetes mellitus is caused by complex organ-specific cellular mechanisms contributing to impaired insulin secretion and insulin resistance.
Argoud, K +20 more
core +6 more sources
Genome-wide linkage analysis of global gene expression in loin muscle tissue identifies candidate genes in pigs. [PDF]
PLoS ONE, 2011 BACKGROUND: Nearly 6,000 QTL have been reported for 588 different traits in pigs, more than in any other livestock species. However, this effort has translated into only a few confirmed causative variants.
Juan Pedro Steibel +10 more
doaj +1 more source
FIVEx: an interactive eQTL browser across public datasets
Bioinform., 2021 SUMMARY Expression quantitative trait loci (eQTLs) characterize the associations between genetic variation and gene expression to provide insights into tissue-specific gene regulation.
Alan M. Kwong +6 more
semanticscholar +1 more source
Fast eQTL Analysis for Twin Studies [PDF]
Genetic Epidemiology, 2015 ABSTRACTTwin data are commonly used for studying complex psychiatric disorders, and mixed effects models are one of the most popular tools for modeling dependence structures between twin pairs. However, for eQTL (expression quantitative trait loci) data where associations between thousands of transcripts and millions of single nucleotide polymorphisms ...
Zhaoyu, Yin +4 more
openaire +2 more sources
Inference of modules associated to eQTLs [PDF]
Nucleic Acids Research, 2012 Cataloging the association of transcripts to genetic variants in recent years holds the promise for functional dissection of regulatory structure of human transcription. Here, we present a novel approach, which aims at elucidating the joint relationships between transcripts and single-nucleotide polymorphisms (SNPs). This entails detection and analysis
Kreimer, Anat +5 more
openaire +2 more sources
Methylation-eQTL analysis in cancer research
Bioinformatics, 2021 AbstractMotivationDNA methylation is a key epigenetic factor regulating gene expression. While promoter methylation has been well studied, recent publications have revealed that functionally important methylation also occurs in intergenic and distal regions, and varies across genes and tissue types.
Yusha Liu +12 more
openaire +2 more sources
HT-eQTL: integrative expression quantitative trait loci analysis in a large number of human tissues
BMC Bioinformatics, 2018 Background Expression quantitative trait loci (eQTL) analysis identifies genetic markers associated with the expression of a gene. Most existing eQTL analyses and methods investigate association in a single, readily available tissue, such as blood. Joint
Gen Li +3 more
doaj +1 more source
Bipartite Community Structure of eQTLs
PLOS Computational Biology, 2016 Genome Wide Association Studies (GWAS) and eQTL analyses have produced a large and growing number of genetic associations linked to a wide range of human phenotypes. As of 2013, there were more than 11,000 SNPs associated with a trait as reported in the NHGRI GWAS Catalog.
John Platig +3 more
openaire +6 more sources
Joint analysis of SNP and gene expression data in genetic association studies of complex diseases [PDF]
, 2014 Genetic association studies have been a popular approach for assessing the association between common Single Nucleotide Polymorphisms (SNPs) and complex diseases.
Huang, Yen-Tsung +2 more
core +1 more source
PLoS ONE, 2014 Most genome-wide association studies consider genes that are located closest to single nucleotide polymorphisms (SNPs) that are highly significant for those studies.
Kyung-Won Hong +3 more
doaj +1 more source