Results 71 to 80 of about 40,172 (233)

Overlap between eQTL and QTL associated with production traits and fertility in dairy cattle

BMC Genomics, 2019
Background Identifying causative mutations or genes through which quantitative trait loci (QTL) act has proven very difficult. Using information such as gene expression may help to identify genes and mutations underlying QTL.
I. van den Berg, B. J. Hayes, A. J. Chamberlain, M. E. Goddard   +3 more
doaj   +1 more source

Multi‐Tissue Omics Analysis Uncovers Translational Regulation Underlying Complex Traits in Pigs

Advanced Science, EarlyView.
Integrated multi‐omics across pig breeds and tissues reveals key principles of post‐transcriptional translational regulation and their contribution to trait formation. A gene network framework integrating transcriptomic and translatomic data is developed and applied to elucidate the genetic basis of meat production, offering new insights into mammalian
Chao Wang, Yuanyuan Zhang, Choulin Chen, Xiaoxian Xu, Shenghua Qin, Junyan Qi, Yongzhou Bao, Huiming Li, Ruipu Chen, Weigang Zheng, Zhilong Chen, Lingzhao Fang, Yunxiang Zhao, Yuwen Liu   +13 more
wiley   +1 more source

A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior [PDF]

, 2015
Glyoxalase 1 (Glo1) has been implicated in anxiety-like behavior in mice and in multiple psychiatric diseases in humans. We used mouse Affymetrix exon arrays to detect copy number variants (CNV) among inbred mouse strains and thereby identified a ...
Borevitz, Justin O., Distler, Margaret G., Harr, Bettina, Lim, Jackie E., Palmer, Abraham A., Sokoloff, Greta, Su, Andrew I., Tarantino, Lisa M., Teschke, Meike, Walters, Ryan, Williams, Richard, Wiltshire, Tim, Wing, Claudia, Wu, Chunlei   +13 more
core   +2 more sources

Tissue Damage in Rheumatoid Arthritis is Genetically linked to Low Peptidylglycine Alpha‐Amidating Monooxygenase Activity in Synovial Fibroblasts

Arthritis &Rheumatology, Accepted Article.
Objectives Both susceptibility to, and severity of, rheumatoid arthritis (RA) is associated with the rs26232 C allele. Our primary aim was to identify the biological mechanism underlying this association. Methods Expression of surrounding genes was compared between rs26232 genotypes.
Kevin J. Sheridan, Emma R. Dorris, Maria Inês Pimenta, Jemma Falkov, Matthew Fisher, Sam Pledger, Hector Devey, Munitta Muthana, Denis C. Shields, Richard E Mains, Betty A Eipper, Christopher D. Buckley, Anthony G. Wilson   +12 more
wiley   +1 more source

ULK4 and CDKN2A polymorphisms influence the risk of developing monoclonal gammopathy of undetermined significance

International Journal of Cancer, EarlyView.
What's New? Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic precursor to multiple myeloma, sharing substantial genetic features with overt malignancy. Given evidence implicating autophagy in myeloma risk, this study examined whether genetic variations in autophagy‐related genes influence MGUS susceptibility.
José Manuel Sánchez‐Maldonado, Angelica Macauda, Antonio José Cabrera‐Serrano, Hauke Thomsen, Murat Güler, Rob Ter Horst, Bethany van Guelpen, Pavel Vodicka, Stefano Landi, Subhayan Chattopadhyay, Pelin Ünal, Lucía Ruiz‐Durán, Delphine Casabonne, Hartmut Goldschmidt, Istemi Serin, María Carretero‐Fernández, Elena Cabezudo, Fernando Reyes‐Zurita, Aaron D. Norman, Ramón García‐Sanz, Gabriele Capurso, Per Hoffmann, Ulrika Pettersson‐Kymmer, Francisco Jiménez‐Romera, S. Vincent Rajkumar, Niels Weinhold, Ludmila Vodickova, Christian Langer, Angelika Stein, Abdulkadir Karismaz, Victor Moreno, Markus M. Nöthen, Karl‐Heinz Jöckel, Francesca Tavano, Joaquín Martínez‐López, Shaji K. Kumar, Juan Francisco Gutiérrez‐Bautista, Daniela Basso, Florentin Späth, Yolanda Benavente, Michelle A. T. Hildebrandt, Börge Schmidt, Tereza Sevcikova, Rui Manuel Vieira Reis, Yang Li, Miguel Ángel López‐Nevot, Mihai G. Netea, Daniele Campa, Alyssa Clay‐Gilmour, Susan L Slager, Kari Hemminki, Celine M Vachon, Asta Försti, Federico Canzian, Juan Sainz   +54 more
wiley   +1 more source

Meta-analysis of massively parallel reporter assays enables prediction of regulatory function across cell types. [PDF]

, 2019
Deciphering the potential of noncoding loci to influence gene regulation has been the subject of intense research, with important implications in understanding genetic underpinnings of human diseases.
Ahituv, Nadav, Kreimer, Anat, Yan, Zhongxia, Yosef, Nir   +3 more
core  

Identification of expression QTL (eQTL) of genes expressed in porcine M. longissimus dorsi and associated with meat quality traits

BMC Genomics, 2010
Background Genetic analysis of transcriptional profiles is a promising approach for identifying and dissecting the genetics of complex traits like meat performance.
Schellander Karl, Schwerin Manfred, Murani Eduard, Ponsuksili Siriluck, Wimmers Klaus   +4 more
doaj   +1 more source

MendelR: A One‐Stop R Toolkit for Mendelian Randomization Analysis

Med Research, EarlyView.
ABSTRACT MendelR is a fully automated R package specifically developed for Mendelian randomization (MR) studies, designed to address the technical challenges of causal inference in biomedical research. As a powerful causal inference method, Mendelian randomization can effectively reduce confounding bias in observational studies.
Xiaohong Ke, Kailai Li, Anqi Lin, Yasi Zhang, Peng Luo   +4 more
wiley   +1 more source

Bayesian methods for genetic association analysis with heterogeneous subgroups: From meta-analyses to gene-environment interactions

, 2014
Genetic association analyses often involve data from multiple potentially-heterogeneous subgroups. The expected amount of heterogeneity can vary from modest (e.g., a typical meta-analysis) to large (e.g., a strong gene--environment interaction). However,
Stephens, Matthew, Wen, Xiaoquan
core   +1 more source

Exploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts [PDF]

, 2014
OBJECTIVE: IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies.
Agreus, Lars, Andreasson, Anna, Assadi, Ghazaleh, Barbara, Giovanni, Barbaro, Raffaella, Bellini, Massimo, Blandizzi, Corrado, Boeckxstaens, Guy, Bresso, Francesca, Burwinkel, Barbara, Camilleri, Michael, Colucci, Rocchina Lucia, D'Amato, Mauro, Daly, Mark J., Dlugosz, Aldona, Ek, Weronica E., Gambaccini, Dario, Gazouli, Maria, Holliday, Elizabeth G., Houghton, Lesley, Karamanolis, George, Karling, Pontus, Li, Ling, Lindberg, Greger, Magnusson, Patrik, Marchi, Santino, Niesler, Beate, Ohlsson, Bodil, Papadaki, Evangelia, Pedersen, Nancy L., Rafter, Joseph, Rappold, Gudrun, Reznichenko, Anna, Ripke, Stephan, Rivera, Natalia V., Schmidt, Peter T., Simren, Magnus, Stanghellini, Vincenzo, Surowy, Harald, Talley, Nicholas J., Tornblom, Hans, Walter, Susanna, Wouters, Mira M., Zucchelli, Marco   +43 more
core   +1 more source