Results 71 to 80 of about 41,400 (238)
Evolutionary Analysis of Transcriptional Regulation Mediated by Cdx2 in Rodents
Cell Proliferation, EarlyView.Our study (1) represented a first systematic analysis of species‐specific adaptation in the DNA binding pattern of transcription factor; (2) represented a first study of cis‐regulation between two reproductively isolated species by using a novel allodiploid system; (3) demonstrated a higher conservation of transcriptional output than that of DNA ...Weizheng Liang, Guipeng Li, Yukai Wang, Wencheng Wei, Rui Chen, Siyue Sun, Diwen Gan, Hongyang Yi, Bernhard Schaefke, Yuhui Hu, Qi Zhou, Wei Li, Huanhuan Cui, Wei Chen +13 morewiley +1 more sourceInsight into genetic regulation of miRNA in mouse brain
BMC Genomics, 2019 Background micro RNA (miRNA) are important regulators of gene expression and may influence phenotypes and disease traits. The connection between genetics and miRNA expression can be determined through expression quantitative loci (eQTL) analysis, which ...Gordon Kordas, Pratyaydipta Rudra, Audrey Hendricks, Laura Saba, Katerina Kechris +4 moredoaj +1 more sourceMediation analysis demonstrates that trans-eQTLs are often explained by cis-mediation: a genome-wide analysis among 1,800 South Asians. [PDF]
PLoS Genetics, 2014 A large fraction of human genes are regulated by genetic variation near the transcribed sequence (cis-eQTL, expression quantitative trait locus), and many cis-eQTLs have implications for human disease.Brandon L Pierce, Lin Tong, Lin S Chen, Ronald Rahaman, Maria Argos, Farzana Jasmine, Shantanu Roy, Rachelle Paul-Brutus, Harm-Jan Westra, Lude Franke, Tonu Esko, Rakibuz Zaman, Tariqul Islam, Mahfuzar Rahman, John A Baron, Muhammad G Kibriya, Habibul Ahsan +16 moredoaj +1 more sourceExploring the genetics of irritable bowel syndrome: A GWA study in the general population and replication in multinational case-control cohorts [PDF]
, 2014 OBJECTIVE:
IBS shows genetic predisposition, but adequately powered gene-hunting efforts have been scarce so far. We sought to identify true IBS genetic risk factors by means of genome-wide association (GWA) and independent replication studies.Agreus, Lars, Andreasson, Anna, Assadi, Ghazaleh, Barbara, Giovanni, Barbaro, Raffaella, Bellini, Massimo, Blandizzi, Corrado, Boeckxstaens, Guy, Bresso, Francesca, Burwinkel, Barbara, Camilleri, Michael, Colucci, Rocchina Lucia, D'Amato, Mauro, Daly, Mark J., Dlugosz, Aldona, Ek, Weronica E., Gambaccini, Dario, Gazouli, Maria, Holliday, Elizabeth G., Houghton, Lesley, Karamanolis, George, Karling, Pontus, Li, Ling, Lindberg, Greger, Magnusson, Patrik, Marchi, Santino, Niesler, Beate, Ohlsson, Bodil, Papadaki, Evangelia, Pedersen, Nancy L., Rafter, Joseph, Rappold, Gudrun, Reznichenko, Anna, Ripke, Stephan, Rivera, Natalia V., Schmidt, Peter T., Simren, Magnus, Stanghellini, Vincenzo, Surowy, Harald, Talley, Nicholas J., Tornblom, Hans, Walter, Susanna, Wouters, Mira M., Zucchelli, Marco +43 morecore +1 more sourceWhole Blood Transcriptomic Analysis of Sickle Cell Trait
European Journal of Haematology, EarlyView.ABSTRACT
Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner +12 morewiley +1 more sourceParent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. [PDF]
, 2014 Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality.A Kong, A Lomniczi, A Murphy, A Schröder, AA D’Aloisio, Aarno Palotie, AB Migliano, Adamo Pio D’adamo, Aida K. Dieffenbach, AL Dixon, Albert Hofman, Albert V. Smith, Albertine J. Oldehinkel, Alexander Teumer, Alison M. Dunning, Andrea D. Coviello, Andrea Ganna, Andres Metspalu, Andrew C. Heath, Andrew D. Johnson, André G. Uitterlinden, Angela Cox, Anja Rudolph, Anna M. Storniolo, Anna Murray, Anneli Pouta, Annika Lindblom, Antonietta Robino, AP Abreu, Arto Mannermaa, AS Dimas, AV Segrè, B Kabakchiev, B Zhang, BE Stranger, Behrooz Z. Alizadeh, Ben A. Oostra, Bernardo Bonanni, Bjarke Feenstra, BP Fairfax, Bruce H. R. Wolffenbuttel, C Colantuoni, C Liu, C-J Partsch, Carl Blomqvist, Catharina A. Hartman, Cathy E. Elks, CE Elks, Christian Gieger, Chunyan He, CJ Willer, Cornelia M. van Duijn, CP Schaaf, Craig E. Pennell, D Mehta, D Sasayama, DA Cusanovich, Daniel F. Gudbjartsson, Daniel I. Chasman, Daniel L. Koller, David Couper, David J. Hunter, David Karasik, David P. Strachan, David Schlessinger, Debbie Lawlor, Deborah J. Thompson, Diana L. Cousminer, Dieter Flesch-Janys, Diether Lambrechts, Dirkje S. Postma, DM Greenawalt, Doris Stöckl, Dorret I. Boomsma, Douglas F. Easton, Douglas P. Kiel, E Grundberg, E Grundberg, E Grundberg, Eco E. J. de Geus, EE Schadt, EK Speliotes, EL Heinzen, Eleonora Porcu, Elisabeth Widen, Elizabeth A. Streeten, Ellen A. Nohr, Ellen W. Demerath, Emmi Tikkanen, Enda M. Byrne, Eric Boerwinkle, Erik Ingelsson, Erin K. Wagner, Eva Albrecht, Evelin Mihailov, F Innocenti, F Nagl, F Zou, Felix Day, Femke Atsma, Fergus J. Couch, Fernando Rivadeneira, Frank B. Hu, Frank Geller, GA Heap, George Davey Smith, George McMahon, Georgia Chenevix-Trench, Gerard Waeber, Gisli Masson, Gonneke Willemsen, Graham G. Giles, Grant W. Montgomery, Gudmar Thorleifsson, Gudny Eiriksdottir, H Lango Allen, H-J Westra, Harold Snieder, Heather A. Boyd, Heli Nevanlinna, Henri Wallaschofski, Henrik Flyger, Henry Völzke, Hermann Brenner, HHH Göring, Hiltrud Brauch, Hoda Anton-Culver, IK Temple, Ilja M. Nolte, Immaculata De Vivo, Irene L. Andrulis, J Ding, J Huang, J Yang, J Yang, J Yang, J. Margriet Collée, JA Webster, Javier Benitez, JC Barrett, Jenny A. Visser, Jenny Chang-Claude, JF Degner, Jing Hua Zhao, Jinhui Chen, Joanne M. Murabito, Joe Dennis, Johan G. Eriksson, John L. Hopper, John P. Rice, John R. B. Perry, Jonathan Tyrer, Jouke-Jan Hottenga, JR Gibbs, Julia A. Knight, Julian Peto, Julie E. Buring, K Estrada, K Hao, K Michailidou, Kamila Czene, Kari Stefansson, Kathryn L. Lunetta, Katri Pylkäs, Kay-Tee Khaw, Ken K. Ong, KS Kompass, Kyriaki Michailidou, L Liang, Laura Crisponi, Laura J. Bierut, Laura M. Yerges-Armstrong, Lavinia Paternoster, LB Barreiro, LFG Silveira, Lili Milani, Lisette Stolk, Lude Franke, Luigi Ferrucci, Lynda M. Rose, M Horikoshi, M Rantalainen, Maartje J. Hooning, Mads Melbye, Manjeet K. Bolla, Marek Zygmunt, Margaret J. Wright, Marjanka K. Schmidt, Marjo-Riitta Järvelin, Mark I. McCarthy, Massimo Mangino, Matthias W. Beckmann, Meir J. Stampfer, Melanie Waldenberger, Melissa E. Garcia, Mellissa C. Southey, Michael J. Econs, Montserrat García-Closas, Munro Peacock, N Ruf, Najaf Amin, Nancy L. Pedersen, Natalia Tšernikova, Nicholas G. Martin, Nicholas J. Timpson, Nicholas J. Wareham, Nora Franceschini, P Prentice, Paolo Gasparini, Paolo Peterlongo, Paolo Radice, Pascal Guénel, Patrick F. McArdle, Patrick Neven, Patrick Sulem, Patrik K. Magnusson, Paul D. P. Pharoah, Paul M. Ridker, Per Hall, Peter A. Fasching, Peter Devilee, Peter Kraft, Peter Vollenweider, Q Li, Qin Wang, Reedik Mägi, Robert Winqvist, Robin Haring, Roger L. Milne, RP Grinspon, RS Huang, RSN Fehrmann, Ruth J. F. Loos, S Cho, S Constantin, S Sulzbacher, Sandra Lai, Sanela Kjellqvist, SE Parker, Serena Sanna, Sheila Ulivi, Stefania Bandinelli, Stephen Chanock, Stig E. Bojesen, Suiqun Guo, Susan Ring, Sven Bergmann, T Kwan, T Maeda, T Zeller, Tamara B. Harris, Tanguy Corre, Tatiana Foroud, Teresa Ferreira, Thorkild I. A. Sørensen, Tim D. Spector, Tune H. Pers, Tõnu Esko, Ulla Sovio, Unnur Thorsteinsdottir, Ute Hamann, V Emilsson, Veikko Salomaa, Veli-Matti Kosma, Vilmundur Gudnason, W Zheng, Wei Q. Ang, Wendy L. McArdle, Y Idaghdour, Y Stelzer, Z Zadik, Zoltan Kutalik +271 morecore +7 more sourcesGenetic risk factor identification for common epilepsies guided by integrative omics data analysis
Epilepsia, EarlyView.Abstract Objective
Genetic generalized epilepsies (GGEs) comprise the most common genetically determined epilepsy syndromes, following a complex mode of inheritance. Although many important common and rare genetic factors causing or contributing to these epilepsies have been identified in the past decades, many features of the genetic architecture are ...Ashwini Mushunuri, Oluyomi Adesoji, Roland Krause, Patrick May, Holger Lerche, Albert Becker, Daniela Grimm, International League Against Epilepsy Consortium on Complex Epilepsies, Michael Nothnagel, Herbert Schulz +9 morewiley +1 more sourceA Principled Framework for Mendelian Randomization in Oral Health Research
Journal of Periodontal Research, EarlyView.This methodological article provides a clear and accessible overview of Mendelian randomization for oral health researchers, emphasizing the core assumptions needed for credible causal inference. Focusing on applications in oral health, particularly periodontitis, it highlights both the strengths and limitations of the study design in order to support ...Nasir Z. Bashir, Mario Romandini, Moritz Kebschull, Konstantinos K. Tsilidis, Dominique S. Michaud, Stephen Burgess +5 morewiley +1 more source
