Results 91 to 100 of about 975,907 (284)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Communication-efficient public key encryption with (fine-grained delegated) equality test

Cybersecurity
With the rise of cloud storage and the looming threat of quantum computing, traditional encryption methods are encountering significant challenges that hinder data manipulation without decryption.
Wanqing Wang, Xiangxue Li, Xiaogang Zhou
doaj   +1 more source

The effectiveness of a gender equality course in changing undergraduate midwifery students’ attitudes towards domestic violence and gender roles

Central European Journal of Nursing and Midwifery, 2018
Aim: The aim of the study is to evaluate the effectiveness of a gender equality course in changing undergraduate midwifery students’ attitudes towards domestic violence and gender roles. Design: A one-group before-after quasi-experimental design was used.
Emel Bahadir Yilmaz
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Lattice-based ABE with multi-ciphertext equality test in cloud computing

Journal of King Saud University: Computer and Information Sciences
Data is typically encrypted before transmission to a cloud server to safeguard user privacy. However, such encryption prevents the server from performing searches on the data, necessitating the introduction of novel cryptographic primitives, such as ...
Mengdi Zhao, Huiyan Chen, Yunfei Yao, Xi Lin   +3 more
doaj   +1 more source

Swap Test-Based Quantum Protocol for Private Array Equality Comparison

Mathematics
Private array equality comparison (PAEC) aims to evaluate whether two arrays are equal while maintaining the confidentiality of their elements. Current private comparison protocols predominantly focus on determining the relationships of secret integers ...
Min Hou, Shibin Zhang
doaj   +1 more source

Comparison of Approaches to Testing Equality of Expectations Among Samples from Poisson and Negative Binomial Distribution

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2018
The paper deals with testing of the hypothesis of equality of expectations among p samples from Poisson or negative binomial distribution. a comparison of two main approaches is carried out.
Martin Tejkal, Zuzana Hübnerová
doaj   +1 more source

Quantum-like modeling of the order effect in decision making: POVM viewpoint on the Wang-Busemeyer QQ-equality

, 2018
In recent years, quantum mechanics has been actively used in areas outside of physics, such as psychology, sociology, theory of decision-making, game theory, and others.
Khrennikov, Andrei, Lebedev, Aleksandr
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source