Results 51 to 60 of about 173,503,456 (301)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Modified couple stress-based third-order theory for nonlinear analysis of functionally graded beams

Latin American Journal of Solids and Structures
A microstructure-dependent nonlinear third-order beam theory which accounts for through-thickness power-law variation of a two-constituent material is developed using Hamilton's principle.
A. Arbind, J.N. Reddy, A. R. Srinivasa
doaj   +1 more source

Linear orbit parameters for the exact equations of motion [PDF]

, 1994
This paper defines the beta function and other linear orbit parameters using the exact equations of motion. The {beta}, {alpha} and {psi} functions are redefined using the exact equations.
George Parzen, Parzen, G.
core   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Comparing motion induction in lateral motion and motion in depth [PDF]

, 2008
Induced motion, the apparent motion of an object when a nearby object moves, has been shown to occur in a variety of different conditions, including motion in depth.
Harris, Julie, German, KJ, Harris, Julie; id_orcid   +2 more
core   +1 more source

Second-Order Approximate Equations of the Large-Scale Atmospheric Motion Equations and Symmetry Analysis for the Basic Equations of Atmospheric Motion

, 2022
In this paper, symmetry properties of the basic equations of atmospheric motion are proposed. The results on symmetries show that the basic equations of atmospheric motion are invariant under space-time translation transformation, Galilean translation ...
Ping Liu, Senyue Lou, Lei Peng
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Secular Perturbations of Translational–Rotational Motion of an Axisymmetric Body in the Restricted Three-Body Problem with Variable Masses

Axioms
We consider the translational–rotational motion of a small axisymmetric body in the gravitational field of two stars of variable masses moving under the influence of their mutual gravitational attraction.
Alexander Prokopenya, Mukhtar Minglibayev, Balnur Assan   +2 more
doaj   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source