Results 41 to 50 of about 10,252,023 (301)
Acupuncture Mechanism and Redox Equilibrium [PDF]
Evidence-Based Complementary and Alternative Medicine, 2014 Oxidative stress participates in the pathological process of various diseases. Acupuncture is a component of the health care system in China that can be traced back for at least 3000 years. Recently, increased evidences indicate that acupuncture stimulation could reduce oxidative damage in organisms under pathological state, but the exact mechanism ...
Zeng, Xiang-Hong +4 more
openaire +2 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Scientific Reports, 2022 Crossing the cellular membrane is one of the main barriers during drug discovery; many potential drugs are rejected for their inability to integrate into the intracell fluid.
Diego Muñoz-Gacitúa +2 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
EQUILIBRIUM LENDING MECHANISM AND AGGREGATE ACTIVITY* [PDF]
International Economic Review, 2001 We construct a model of the credit market where financial contracting is subject to costly state verification and moral hazard. The economy's aggregate activity and its equilibrium lending mechanism are determined jointly. We analyze how changes in the model's exogenous variables, including the returns of the economy's investment projects and the ...
Cheng Wang, Ruilin Zhou
openaire +2 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Coannihilation without chemical equilibrium [PDF]
, 2017 Chemical equilibrium is a commonly made assumption in the freeze-out calculation of coannihilating dark matter. We explore the possible failure of this assumption and find a new conversion-driven freeze-out mechanism.
M. Garny +3 more
semanticscholar +1 more source
Fluid dynamics of out of equilibrium boost invariant plasmas [PDF]
Nuclear Physics, 2017 By solving a simple kinetic equation, in the relaxation time approximation, and for a particular set of moments of the distribution function, we establish a set of equations which, on the one hand, capture exactly the dynamics of the kinetic equation ...
J. Blaizot, Li Yan
semanticscholar +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Analytical Method for Mechanism Design in Partially Observable Markov Games
Mathematics, 2021 A theme that become common knowledge of the literature is the difficulty of developing a mechanism that is compatible with individual incentives that simultaneously result in efficient decisions that maximize the total reward.
Julio B. Clempner, Alexander S. Poznyak
doaj +1 more source