Results 51 to 60 of about 10,252,023 (301)
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Basic study on the characteristics of a singular mechanism and its application to the robot arm
Nihon Kikai Gakkai ronbunshu, 2019 This paper shows a singular mechanism for a gravity compensated and reactionless robot arm. Firstly, the difference between singular point and singular mechanism is explained.
Koichi HARIMA
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
THE INERTIA FORCE EQUILIBRIUM ANALYSIS OF CRANK-GROUP DRIVING MECHANISM
Jixie qiangdu, 2017 Aiming at overcoming the deficiency of balance of the Crank-group Driving Mechanism,utilize Mass moment substitution method to translate the equilibrium problem of inertia force of Crank-group Driving Mechanism into the additional mass moment of branch ...
WU Yao +3 more
doaj
A novel global chemical reaction mechanism for large-scale hydrogen detonation simulation
Case Studies in Thermal EngineeringConventional modeling strategies for large-scale detonation simulations suffer from a critical trade-off: detailed chemical mechanisms involve excessive computational costs, while typical single-step schemes lack sufficient predictive accuracy.
Xin Lin +5 more
doaj +1 more source
Static Balancing of Robot Mechanisms and Manipulation Devices
Journal of Mechanical Engineering, 2018 The paper deals with static balancing of various kinds of mechanisms and manipulation devices using spring balancing mechanisms. In case of parallelogram robots and manipulation mechanisms a spring balancing mechanism exerting a constant force is used ...
Segla Stefan
doaj +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source