Results 31 to 40 of about 410,463 (191)

An Integrative miRNA-mRNA Expression Analysis Reveals Striking Transcriptomic Similarities between Severe Equine Asthma and Specific Asthma Endotypes in Humans. [PDF]

, 2020
Severe equine asthma is an incurable obstructive respiratory condition affecting 10-15% of horses in temperate climates. Upon exposure to airborne antigens from hay feeding, affected horses show neutrophilic airway inflammation and bronchoconstriction ...
Jean-Pierre Lavoie, Pacholewska, Alicja, Vidhya Jagannathan, Hulliger, Matthias F., Tosso Leeb, Jagannathan, Vidya, Vargas, Amandine, Alicja Pacholewska, Lavoie, Jean-Pierre, Leeb, Tosso, Matthias F. Hulliger, Amandine Vargas, Gerber, Vinzenz, Vincent Gerber   +13 more
core   +2 more sources

Biomarkers of equine asthma: A review of the current literature. [PDF]

Vet Res Commun
Abstract Equine Asthma (EA) is a common, lower airway disease. Yet current diagnostic standards rely on bronchoalveolar lavage fluid (BALF) cytology, which is moderately invasive and not always feasible in field conditions. This review aimed to synthesize current evidence on candidate biomarkers of EA, with a primary focus on blood ...
Długopolska D, Siwińska N, Noszczyk-Nowak A, Niedźwiedź A, Żak-Bochenek A.   +4 more
europepmc   +2 more sources

Antimicrobial Prescription Behavior in Equine Asthma Cases: An International Survey. [PDF]

Animals (Basel)
Equine asthma is considered a non-infectious respiratory disease characterized by inflammation and hypersensitivity. Given the importance of antimicrobial stewardship, an international survey was designed to investigate the use of antimicrobials in ...
van den Brom-Spierenburg AJ, Mureșan AN, Westermann CM.   +2 more
europepmc   +2 more sources

Equine asthma in Brazil – a scoping review

Research, Society and Development, 2022
Asthma is a chronic respiratory disease that can occur in horses of different breeds and ages. While its occurrence has been reported in many countries, its occurrence across Brazil is unclear. This review aimed to gather information about equine asthma from studies performed in Brazil by different groups and investigate a variety of horse populations.
Tiago Marcelo Oliveira, Pedro Vicente Michelotto Junior, Wilson Roberto Fernandes, Stefano Strano Calomeno   +3 more
openaire   +2 more sources

Efficacy of tamoxifen for the treatment of severe equine asthma [PDF]

Journal of Veterinary Internal Medicine, 2018
Abstract Background Tamoxifen, a selective estrogen receptor modulator, decreased airway neutrophilia and improved clinical signs in an experimental model of equine asthma, and induced neutrophilic apoptosis in vitro.
Sophie Mainguy-Seers, Khristine Picotte, Jean-Pierre Lavoie   +2 more
openaire   +2 more sources

Effect of injected dexamethasone on relative cytokine mRNA expression in bronchoalveolar lavage fluid in horses with mild asthma

BMC Veterinary Research, 2019
Background Mild equine asthma is a common inflammatory airway disease of the horse. The primary treatment of mild equine asthma is corticosteroids. The purpose of this study was to investigate the effects of injected dexamethasone on relative IL-1β, IL-4,
Stephanie L. Bond, Jana Hundt, Renaud Léguillette   +2 more
doaj   +1 more source

Leukotriene B4 in equine asthma syndrome: what do we know so far? [PDF]

Pesquisa Veterinária Brasileira, 2019
: The term “equine asthma syndrome” (EAS) was recently proposed due to the resemblance of the equine disease to human asthma. Leukotrienes cause constriction of the bronchi, especially in the lower airways and increase mucus secretion in the respiratory ...
Juliana N.P. Otaka, Luis F.A. Toledo, Katia M. Silva, Andreza A. Silva, Laís Agra, Bruno L. Diaz, Daniel A.B. Lessa   +6 more
doaj   +1 more source

Alveolar macrophage phenotypes in severe equine asthma

The Veterinary Journal, 2020
Because the alveolar macrophage (AM) phenotype of horses with severe equine asthma (SEA) is unknown, the cytokines expressed by M1- and M2-polarized AM were determined and the hypothesis that natural hay/straw challenge (NC) induces divergent AM phenotypes in control horses and horses with SEA was tested.
M E, Wilson, E E, McCandless, M A, Olszewski, N Edward, Robinson   +3 more
openaire   +3 more sources

Neutrophil gelatinase‐associated lipocalin as a potential biomarker for equine asthma [PDF]

Equine Veterinary Journal, 2023
Abstract Background Studies in people have found neutrophil gelatinase‐associated lipocalin (NGAL) concentrations are increased in asthma and can be used to distinguish between asthma subtypes. NGAL has not yet been investigated in equine asthma (EA).
Sanni Hansen, Nina D. Otten, Liv Spang‐Hanssen, Christine Bendorff, Stine Jacobsen   +4 more
openaire   +3 more sources

Managing the pediatric patient with refractory asthma: a multidisciplinary approach [PDF]

, 2017
Children with asthma that is refractory to high levels of prescribed treatment are described as having problematic severe asthma. Those in whom persistent symptoms result from a failure of basic asthma management are described as having “difficult asthma”
Winch, D, Bush, A, Housley, G, Valentina Fainardi, Beresford, F, Angela Jamalzadeh, Sejal Saglani, Hall, P, Fainardi, V, Saglani, S, David Winch, Michelle Nightingale, Fran Beresford, Andrew Bush, Cook, J, Louise Fleming, Fleming, L, James Cook, Jamalzadeh, A, Nightingale, M, Pippa Hall, Georgie Housley   +21 more
core   +1 more source