Results 41 to 50 of about 219,775 (187)

MSI-1436 improves EMS adipose derived progenitor stem cells in the course of adipogenic differentiation through modulation of ER stress, apoptosis, and oxidative stress

Stem Cell Research & Therapy, 2021
Background Protein tyrosine phosphatase 1B (PTP1B) is one of the major negative regulators of leptin and insulin signaling, and has been strongly implicated in insulin resistance development in the course of obesity and metabolic syndrome conditions ...
Lynda Bourebaba, Katarzyna Kornicka-Garbowska, Mohamad Al Naem, Michael Röcken, Jacek Łyczko, Krzysztof Marycz   +5 more
doaj   +1 more source

Genome-Wide Association Analyses of Equine Metabolic Syndrome Phenotypes in Welsh Ponies and Morgan Horses. [PDF]

Genes (Basel), 2019
Equine metabolic syndrome (EMS) is a complex trait for which few genetic studies have been published. Our study objectives were to perform within breed genome-wide association analyses (GWA) to identify associated loci in two high-risk breeds, coupled ...
Norton E, Schultz N, Geor R, McFarlane D, Mickelson J, McCue M.   +5 more
europepmc   +2 more sources

Demographic, morphologic, hormonal and metabolic factors associated with the rate of improvement from equine hyperinsulinaemia-associated laminitis

BMC Veterinary Research, 2022
Background Although several studies have investigated factors associated with the onset and occurrence of hyperinsulinaemia-associated laminitis (HAL), few have examined the factors associated with the rate of improvement during recovery from an acute ...
Martin Sillence, Alexandra Meier, Melody de Laat, Rebecca Klee, Dania Reiche   +4 more
doaj   +1 more source

The application of a new laminitis scoring method to model the rate and pattern of improvement from equine endocrinopathic laminitis in a clinical setting

BMC Veterinary Research, 2021
Background Endocrinopathic, or hyperinsulinaemia-associated laminitis (HAL) is a common and debilitating equine foot disease, and although no pharmacological treatments are registered, several are under development.
A. Meier, J. McGree, R. Klee, J. Preuß, D. Reiche, M. de Laat, M. Sillence   +6 more
doaj   +1 more source

A study on obesity and risk factors among leisure and polo horses in Kaduna State, Nigeria

Ukrainian Journal of Veterinary and Agricultural Sciences, 2023
Despite the growing concern about the impact of obesity on equine health, little information is available on equine obesity in Nigeria. The study aimed to determine the prevalence of obesity in leisure and polo horses as well as associated risk factors ...
Olumide Odunayo Akinniyi, Anthony Kojo Beku Sackey, Gabriel Enenche Ochube, Philip Wayuta Mshelia   +3 more
doaj   +1 more source

A “modified Obel” method for the severity scoring of (endocrinopathic) equine laminitis [PDF]

PeerJ, 2019
Background Laminitis is a common equine disease characterized by foot pain, and is commonly diagnosed using a five-grade Obel system developed in 1948 using sepsis-related cases.
Alexandra Meier, Melody de Laat, Christopher Pollitt, Donald Walsh, James McGree, Dania B. Reiche, Marcella von Salis-Soglio, Luke Wells-Smith, Ulrich Mengeler, Daniel Mesa Salas, Susanne Droegemueller, Martin N. Sillence   +11 more
doaj   +2 more sources

Genetics of equine metabolic syndrome

Veterinary Record, 2019
Equine metabolic syndrome (EMS) is defined as a complex disorder characterised by a phenotype of insulin dysregulation, obesity and a predisposition toward laminitis, resulting from the combination of one or more inherited genetic alleles and environmental influences.1 Recently, a genome-wide association study (GWAS)2 identified two genetic markers ...
Rodríguez-Sanz, Carolina E., Sevane Fernández, Natalia, Dunner Boxberger, Helene Susana   +2 more
openaire   +3 more sources

Clinical evaluation of the Immulite® 1000 chemiluminescent immunoassay for measurement of equine serum insulin

Frontiers in Veterinary Science, 2023
IntroductionAccurate quantitative analysis of equine insulin in blood samples is critical for assessing hyperinsulinemia in horses. Although there are various laboratory methods for evaluating equine serum insulin, different immunoassays show significant
Yun Young Go, Nicole W. Hazard, Udeni B. R. Balasuriya, Anna M. Chapman, Nanette S. Fitton, Ákos Kenéz, Frank M. Andrews   +6 more
doaj   +1 more source

Definition, Assessment, Health Consequences and Management of Equine Obesity: A Review

Folia Veterinaria, 2023
Obesity is a state of abnormal or excessive fat accumulation. Obesity in horses increases the risk of developing a variety of health issues such as: insulin dysregulation (ID), reduced athleticism, colic, abnormal reproductive performance, laminitis ...
Akinniyi Olumide O., Sackey Anthony K. B., Ochube Gabriel E., Mshelia Philip W., Jolayemi Kelvin O.   +4 more
doaj   +1 more source

Laminitis and the Equine Metabolic Syndrome

Veterinary Clinics of North America: Equine Practice, 2010
Although much has been written about laminitis in the context of its association with inflammatory processes, recognition is growing that most cases of laminitis examined by veterinarians in private practice are those associated with pasture grazing, obesity, and insulin resistance (IR). The term 'endocrinopathic laminitis' has been adopted to classify
Philip J, Johnson, Charles E, Wiedmeyer, Alison, LaCarrubba, V K Seshu, Ganjam, Nat T, Messer   +4 more
openaire   +2 more sources