Results 81 to 90 of about 23,275 (154)

In Vitro Generated Equine Hepatic-Like Progenitor Cells as a Novel Potent Cell Pool for Equine Metabolic Syndrome (EMS) Treatment. [PDF]

Stem Cell Rev Rep, 2023
Marycz K, Bourebaba N, Serwotka-Suszczak A, Mularczyk M, Galuppo L, Bourebaba L.   +5 more
europepmc   +1 more source

Sex hormone-binding globulin (SHBG) mitigates ER stress and improves viability and insulin sensitivity in adipose-derived mesenchymal stem cells (ASC) of equine metabolic syndrome (EMS)-affected horses. [PDF]

Cell Commun Signal, 2023
Bourebaba N, Sikora M, Qasem B, Bourebaba L, Marycz K.   +4 more
europepmc   +1 more source

A practical approach to hyperinsulinaemia in horses with equine metabolic syndrome

Equine Veterinary Education
Summary Laminitis associated with hyperinsulinaemia is a significant cause of morbidity and mortality in horses with equine metabolic syndrome. The diagnosis and management of hyperinsulinaemia are therefore critical to prevent the development of laminitis.
Tania Sundra, Gabriele Rossi, David Rendle, Guy Lester   +3 more
openaire   +1 more source

The PTP1B inhibitor MSI-1436 ameliorates liver insulin sensitivity by modulating autophagy, ER stress and systemic inflammation in Equine metabolic syndrome affected horses. [PDF]

Front Endocrinol (Lausanne), 2023
Bourebaba L, Serwotka-Suszczak A, Pielok A, Sikora M, Mularczyk M, Marycz K.   +5 more
europepmc   +1 more source

Effect of thyrotropin‐releasing hormone stimulation testing on the oral sugar test in horses when performed as a combined protocol

Journal of Veterinary Internal Medicine, 2019
Background The use of parallel dynamic tests to identify insulin dysregulation (ID) and pituitary pars intermedia dysfunction (PPID) in horses could have better diagnostic utility than measuring baseline hormone concentrations, if the tests do not alter ...
Elizabeth Hodge, Alycia Kowalski, Catherine Torcivia, Sue Lindborg, Darko Stefanovski, Kelsey Hart, Nicholas Frank, Andrew vanEps   +7 more
doaj   +1 more source

Diagnosis and management of equine metabolic syndrome

Equine Veterinary Education
Summary Equine metabolic syndrome (EMS) is a prevalent endocrine disorder that increases the risk of hyperinsulinaemia‐associated laminitis (HAL), the most common and clinically significant form of laminitis. The central pathological feature of EMS is insulin dysregulation (ID), which encompasses basal or postprandial ...
openaire   +2 more sources

Equine metabolic syndrome in UK native ponies and cobs is highly prevalent with modifiable risk factors. [PDF]

Equine Vet J, 2021
Carslake HB, Pinchbeck GL, McGowan CM.
europepmc   +1 more source

Methodologies to Identify Metabolic Pathway Differences Between Emaciated and Moderately Conditioned Horses: A Review of Multiple Gene Expression Techniques

Animals
Starvation in horses presents critical welfare, economic, and management challenges with underlying molecular mechanisms of metabolic modification and recovery left poorly defined.
Madeline M. P. Austin, Jennie L. Z. Ivey, Elizabeth A. Shepherd, Phillip R. Myer   +3 more
doaj   +1 more source

Metabogenomics reveals four candidate regions involved in the pathophysiology of Equine Metabolic Syndrome. [PDF]

Mol Cell Probes, 2020
Patterson Rosa L, Mallicote MF, Long MT, Brooks SA.   +3 more
europepmc   +1 more source

Pharmacokinetics of Ertugliflozin, a Sodium-Glucose Co-Transporter-2 Inhibitor (SGLT2i) in Horses After Enteral Administration

Veterinary Sciences
Ertugliflozin is a sodium-glucose co-transporter-2 inhibitor that has demonstrated promise as a treatment for hyperinsulinaemia in horses. Despite the frequent use of ertugliflozin in equine clinical practice, the pharmacokinetics of this drug in horses ...
Naomi C. Kirkwood, Kristopher J. Hughes, Amy L. Lovett, Gregory S. Doran, David I. Rendle, Scott H. Edwards   +5 more
doaj   +1 more source