Results 31 to 40 of about 2,253,050 (243)
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren +8 more
wiley +1 more source
Discrete input equipment design study [PDF]
The study to improve the reliability of the LUT system by discrete input equipment (DIE) is reported. Subjects discussed include: specifications, packaging, aircraft integrated systems, and word formats DIE. It is recommended that maximal use of advanced
core +1 more source
Apparatus for purging systems handling toxic, corrosive, noxious and other fluids Patent [PDF]
, 1967 Fluid transferring system design for purging toxic, corrosive, or noxious fluids and fumes from materials handling equipment for cleansing and accident ...
Gehring, W. E., Hellmann, R. F.
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Induction methods used in low temperature physics [PDF]
, 1975 A study has been made of induction bridges used in low temperature physics.\ud \ud In Part 1 the design of a mutual inductance bridge of the Hartshorn type is discussed.
Caspari, M. +3 more
core +2 more sources
FEBS Open Bio, EarlyView.We obtained potential bacterial laccase‐like multicopper oxidase (LMCO) sequences through metagenomic sequencing. All sequences exhibited significant differences from known LMCOs in databases. To select the most promising candidates, we performed structure prediction and molecular docking using alphafold2, metal3d and rosetta.
Ting Cui +5 more
wiley +1 more source
Design guidelines for remotely maintainable equipment [PDF]
The quantity and complexity of on-orbit assets will increase significantly over the next decade. Maintaining and servicing these costly assets represent a difficult challenge.
Clarke, Margaret M., Manouchehri, Davoud
core +1 more source
Development of a high stability pointing mechanism for wide application [PDF]
, 1982 A recurrent requirement of spaceborne instruments and communications equipment is that of accurate pointing. This need is recognizable in such diverse applications as Star Sensor trimming, Momentum Wheel gimballing, in-orbit adjustment or alignment of ...
Bentall, R. H., Brunnen, A. J. D.
core +1 more source
FEBS Open Bio, EarlyView.Ca2+‐mediated response to DMSO was investigated in Saccharomyces cerevisiae cells expressing Ca2+‐dependent aequorin. Cell exposure to DMSO induced a cytosolic Ca2+ wave dependent on the integrity of the Cch1/Mid1 channel. Deletion of KCS1 or VIP1 genes encoding the phosphoinositol pyrophosphate (PP‐IP) synthases suppressed the DMSO‐induced Ca2 ...
Larisa Ioana Gogianu +4 more
wiley +1 more source