Results 31 to 40 of about 550,203 (284)

Power-Assisted Scissors Reduce Adductor Pollicis Muscle Fatigue: A Comparative Study in Female College Students

Applied Sciences
Hand fatigue commonly occurs in repetitive tasks, such as cutting with scissors, leading to discomfort, reduced productivity, and musculoskeletal disorders.
Kohei Koizumi, Kumiko Sasao, Yoshihiro Senju, Toyohiro Hamaguchi   +3 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Research on the Error Averaging Effect in A Rolling Guide Pair

Chinese Journal of Mechanical Engineering, 2019
By studying the effects of geometric precision on kinematic accuracy, an error mapping model has been established, based on the hypothesis that a motion pair and its installation surface are rigid.
Yanbing Ni, Haiyang Zhou, Cuiyan Shao, Jinhe Li   +3 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Evaluation of Portable, Low-Cost Autorefractor in School Students with Limited Eye Care Access in Northeastern Brazil

Vision
This study compared the refraction measurements of the ClickCheck™ device (CCD), Topcon KR-8000, and subjective clinical refractometry (SCR) in Brazilian public school students with limited access to eye care. Eighty-seven eyes of healthy students aged 7
Francisco Carlos de Castro Neto, Ricardo Noguera Louzada, Daniel Oliveira Dantas, Dillan Cunha Amaral, Claudio do Carmo Chaves Filho, Milton Ruiz Alves   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Development of a Safe Syringe Disposal System Moving towards Automated Syringe Data Collection [PDF]

Healthcare Informatics Research, 2019
ObjectivesAn automatic needle destroyer (ANDY) was developed to prevent needlestick injuries, and usability tests were conducted in several hospitals.
Youhwa Kim, Kwangbin Oh, Namyeong Kim, Jiwon Yun   +3 more
doaj   +1 more source

A Large-Scale Sensor Layout Optimization Algorithm for Improving the Accuracy of Inverse Finite Element Method

Sensors, 2023
The inverse finite element method (iFEM) based on fiber grating sensors has been demonstrated as a shape sensing method for health monitoring of large and complex engineering structures.
Zhenyi Zhao, Kangyu Chen, Yimin Liu, Hong Bao   +3 more
doaj   +1 more source

Research on visual optimization design of machine–machine interface for mechanical industrial equipment based on nonlinear partial equations [PDF]

, 2021
Yan Yan, Bin Zeng, Fahad Alqurashi, Samer Shorman   +3 more
openalex   +1 more source