Results 31 to 40 of about 526,377 (298)
FEBS Letters, EarlyView.Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Deployment Dynamic Modeling and Driving Schemes for a Ring-Truss Deployable Antenna
Chinese Journal of Mechanical EngineeringMesh reflector antennas are widely used in space tasks owing to their light weight, high surface accuracy, and large folding ratio. They are stowed during launch and then fully deployed in orbit to form a mesh reflector that transmits signals.
Baiyan He +5 more
doaj +1 more source
RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
wiley +1 more source
Research on the Error Averaging Effect in A Rolling Guide Pair
Chinese Journal of Mechanical Engineering, 2019 By studying the effects of geometric precision on kinematic accuracy, an error mapping model has been established, based on the hypothesis that a motion pair and its installation surface are rigid.
Yanbing Ni +3 more
doaj +1 more source
FEBS Letters, EarlyView.Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur +5 more
wiley +1 more source
MicromachinesThe acoustically actuated nanomechanical magnetoelectric (ME) antennas represent a promising new technology that can significantly reduce antenna size by 1–2 orders of magnitude compared to traditional antennas.
Xiangyang Li +4 more
doaj +1 more source
A Pavement Piezoelectric Energy Harvester for Small Input Displacements
Micromachines, 2023 In order to collect mechanical energy from human motions on pavement without an obvious disturbance, a piezoelectric harvester for small displacement is proposed. A seesaw mechanism is utilized to transmit the pressure displacement to piezoelectric beams.
Bin Yin, Jiaming Wei, Xin Jiang, Yan Liu
doaj +1 more source
Molecular Oncology, EarlyView.mir‐196a promotes Esophagus Adenocarcinoma aggressiveness. On one hand, mir‐196a targets the valosin‐containing protein (VCP) mRNA, causing the accumulation of c‐MYC protein that leads to high amounts of TERT. On the other hand, mir‐196a targets the inhibitor of NFκB (NFKBIA).
Jesús García‐Castillo +8 more
wiley +1 more source
Sensors, 2022 A method based on an interval arithmetic is proposed to analyze uncertain factors such as the curvature radii, excitation amplitude, and excitation phase of a spherical conformal array antenna.
Guangda Ding +4 more
doaj +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source