Results 61 to 70 of about 1,469,827 (288)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Equivalent uniform live loads under transit vehicles for floor slab of long-span urban transportation hubs

Journal of Asian Architecture and Building Engineering, 2021
Rapid development of long-span urban transportation hubs arouses higher requirements of structural design methods. However, the current design codes do not give effective provisions of the equivalent uniform live load for long-span transportation hubs. A
Yuhang Li, Yang Deng, Aiqun Li, Peng Sun
doaj   +1 more source

Maximum Intersection of Linear Codes and Codes Equivalent to Linear

Journal of Applied and Industrial Mathematics, 2019
Summary: We consider linear codes in a space over a finite field with the Hamming metric. A code is called pseudolinear if it is the image of a linear code under an isometric transformation of the space. We derive an upper bound \((q-2)M/q\) attainable for \(q\geqslant 3\) for the size of the intersection of two different pseudolinear codes of the same
Avgustinovich, Sergeĭ Vladimirovich, Gorkunov, Evgeniĭ Vladimirovich   +1 more
openaire   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Comparison of numerical codes for coupled thermo-hydro-mechanical simulations of fractured media

Journal of Rock Mechanics and Geotechnical Engineering, 2020
Geo-energy and geo-engineering applications, such as improved oil recovery (IOR), geologic carbon storage, and enhanced geothermal systems (EGSs), involve coupled thermo-hydro-mechanical (THM) processes that result from fluid injection and production. In
Ahmad Zareidarmiyan, Hossein Salarirad, Victor Vilarrasa, Kwang-Il Kim, Jaewon Lee, Ki-Bok Min   +5 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

A Code Equivalence between Secure Network and Index Coding

CoRR, 2018
A code equivalence between index coding and network coding was established, which shows that any index-coding instance can be mapped to a network-coding instance, for which any index code can be translated to a network code with the same decoding-error performance, and vice versa.
Lawrence Ong, Jörg Kliewer, Badri N. Vellambi, Phee Lep Yeoh   +3 more
openaire   +2 more sources

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Linear codes over Fq are equivalent to LCD codes for q>3

, 2018
Linear codes with complementary duals (LCD) are linear codes whose intersection with their dual are trivial. When they are binary, they play an important role in armoring implementations against side-channel attacks and fault injection attacks. Nonbinary
Yanfeng Qi, Qi, Yanfeng, Claude Carlet, Chunming Tang, Ruud Pellikaan, Carlet, Claude, Mesnager, Sihem, Pellikaan, Ruud, Sihem Mesnager, Tang, Chunming   +9 more
core   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source