Results 61 to 70 of about 1,022,924 (268)

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Pondering over Focus on Form and Focus on FormS: Are There “Equivalent and Large Effects”?

open access: yesStudies in Applied Linguistics & TESOL, 2007
It is reassuring that Norris and Ortega's (2000) study echoes Long's (1983, as cited in Han, 2004) finding that instruction does positively impact classroom L2 acquisition, provided that appropriate instruction is implemented.
Adrienne Wai Man Lew
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The strong Popov form of nonlinear input–output equations; pp. 193–206 [PDF]

open access: yesProceedings of the Estonian Academy of Sciences, 2018
The equivalence transformations are applied to bring a system of nonlinear input–output (i/o) equations into a nonlinear equivalent of the Popov form, called the strong Popov form, under the assumption that the i/o equations already are in the strong ...
Zbigniew Bartosiewicz   +4 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Equivalent properties of a Mulholland-type inequality with a best possible constant factor and parameters

open access: yesJournal of Inequalities and Applications, 2019
By means of the weight coefficients, using the idea of introduced parameters and the techniques of real analysis, a Mulholland-type inequality with a homogeneous kernel and an equivalent form are provided.
Hongmin Mo, Bicheng Yang
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

On a new discrete Mulholland-type inequality in the whole plane

open access: yesJournal of Inequalities and Applications, 2018
A new discrete Mulholland-type inequality in the whole plane with a best possible constant factor is presented by introducing multi-parameters, applying weight coefficients, and using Hermite–Hadamard’s inequality.
Bicheng Yang, Qiang Chen
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

open access: yesFEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez   +2 more
wiley   +1 more source

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