Results 51 to 60 of about 1,110,603 (243)

On the combined use of averaged strain energy density criteria (ASED) and equivalent material concept (ECC) for the fracture load prediction of additively manufactured PLA v-notched specimens

Procedia Structural Integrity, 2023
The growing introduction into the industrial world of additive fused deposition technologies, for producing functional components made of thermoplastic materials (such as PLA), pushes designers to know which methods for predicting breakage under load can be used to design correctly these elements.
Morettini G., Razavi S. M. J., Staffa A., Palmieri M., Berto F., Cianetti F., Braccesi C.   +6 more
openaire   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Fracture Load Predictions in Short Glass Fiber Reinforced Polyamide 6 U-Notched Specimens Combining the Equivalent Material Concept and the Theory of Critical Distances [PDF]

Journal of Testing and Evaluation, 2018
Abstract This article provides the prediction of fracture loads in single edge notched bending (SENB) specimens made of short glass fiber reinforced polyamide 6 (SGFR-PA6) and containing U-notches. The predictions are obtained through the combination of the equivalent material concept and the theory of critical distances (TCD).
Cicero González, Sergio, Torabi, Ali Reza, Ibáñez Gutiérrez, Francisco Tomás, Azizi, Payman   +3 more
openaire   +2 more sources

A biosemiotic conversation [PDF]

, 2009
In this dialogue, we discuss the contrast between inexorable physical laws and the semiotic freedom of life. We agree that material and symbolic structures require complementary descriptions, as do the many hierarchical levels of their organizations.
Kull, Kalevi, Pattee, Howard H.
core   +3 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Optimum seismic design of concentrically braced steel frames: concepts and design procedures [PDF]

, 2005
A methodology is presented for optimization of the dynamic response of concentrically braced steel frames subjected to seismic excitation, based on the concept of uniform distribution of deformation.
Ascheim, Chopra, Diaz, FEMA 356, Green, Jain, Krawinkler, Lai, Lee, Martinelli, Moghaddam, Moghaddam, Moghaddam, Priestley, SEAOC, UBC, Vidic   +16 more
core   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Prediction of fracture loads in PMMA U‐notched specimens using the equivalent material concept and the theory of critical distances combined criterion

Fatigue & Fracture of Engineering Materials & Structures, 2017
AbstractThis paper provides a methodology for the prediction of fracture loads in notched materials that combines the equivalent material concept with the theory of critical distances. The latter has a linear‐elastic nature and requires material calibration in those cases where the non‐linear material behaviour is significant.
Cicero González, Sergio, Torabi, A.R., Madrazo Acebes, Virginia, Azizi, P.   +3 more
openaire   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source