Results 51 to 60 of about 14,554,155 (235)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Data-driven and physics-constrained acoustic holography based on optimizer unrolling

Acta Acustica
Nearfield Acoustic Holography (NAH) retrieves vibro-acoustic patterns of sound sources from non-contact measurements of sound in their proximity. NAH obtains images of structural vibrations to analyze the underlying acoustic phenomena.
Pagavino Manuel, Zotter Franz
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Reactive Power Control Method for Enhancing the Transient Stability Total Transfer Capability of Transmission Lines for a System with Large-Scale Renewable Energy Sources

Energies, 2020
With the increased proportion of intermittent renewable energy sources (RES) integrated into the sending-end, the total transfer capability of transmission lines is not sufficient during the peak periods of renewable primary energy (e.g., the wind force),
Yuwei Zhang, Wenying Liu, Fangyu Wang, Yaoxiang Zhang, Yalou Li   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Sound Scattering and Its Reduction by a Janus Sphere Type [PDF]

, 2014
Copyright © 2014 Delyia Kim et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.Sound
Kim, D, Miloh, T, AVITAL, E
core   +1 more source

Regularisation of the equivalent source method for robust numerical modelling of acoustic scattering

, 2015
The equivalent source method can be used to model acoustic scattering, by representing the scattering object with a set of equivalent sources that satisfy a boundary condition.
Gan, Woon-Seng, Cheer, Jordan, Elliott, Stephen, Lam, Bhan   +3 more
core   +2 more sources

Gamma scanning technique based on equivalent plane source method in large container

He jishu
BackgroundLarge-volume container waste generated from nuclear facility decommissioning exhibits extremely inhomogeneous nuclide distribution. Its activity measured using the traditional tomographic gamma scanning (TGS) technique shows errors of up to six
XU Li, GU Weiguo, YANG Hui, WANG Dezhong
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source