Results 51 to 60 of about 37,506 (169)

The Sec63p J-domain is required for ERAD of soluble proteins in yeast.

PLoS ONE, 2013
How misfolded proteins are exported from the ER to the cytosol for degradation (ER-associated Degradation, ERAD) and which proteins are participating in this process is not understood.
Christina Servas, Karin Römisch
doaj   +1 more source

Compartmentalization and Trafficking in Endoplasmic Reticulum Protein Quality Control

Biology and Life Sciences Forum, 2023
Following translocation into the rough endoplasmic reticulum (ER), secretory proteins undergo a series of folding, maturation, compartmentalization and trafficking events.
Gerardo Z. Lederkremer
doaj   +1 more source

A new variational approach to the stability of gravitational systems [PDF]

, 2009
We consider the three dimensional gravitational Vlasov Poisson system which describes the mechanical state of a stellar system subject to its own gravity.
A. Alvino, A.M. Fridmann, A.V. Antonov, A.V. Antonov, C. Marchioro, C.S. Gardner, D. Gillon, D. Lynden-Bell, D. Serre, E.H. Lieb, Florian Méhats, G. Wolansky, G. Wolansky, H. Wiechen, H.E. Kandrup, H.E. Kandrup, J. Batt, J. Binney, J. Dolbeault, J. Perez, J. Schaeffer, J. Schaeffer, J.-F. Sygnet, J.-J. Aly, J.P. Doremus, K. Pfaffelmoser, M. Hadźić, M. Lemou, M. Lemou, M. Lemou, M. Lemou, Mohammed Lemou, P.-H. Chavanis, P.-L. Lions, P.-L. Lions, P.-L. Lions, Pierre Raphaël, T. Cazenave, V.I. Arnold, V.I. Arnold, V.I. Arnold, Y. Guo, Y. Guo, Y. Guo, Y. Guo, Y. Guo, Y. Guo, Y.-H. Wan, Z. Lin, Z. Lin, Z. Lin, Ó. Sánchez   +51 more
core   +8 more sources

The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development

Cell Reports, 2016
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a principal mechanism that targets ER-associated proteins for cytosolic proteasomal degradation.
Yewei Ji, Hana Kim, Liu Yang, Haibo Sha, Christopher A. Roman, Qiaoming Long, Ling Qi   +6 more
doaj   +1 more source

Higher dimensional Numerical Relativity: code comparison [PDF]

, 2014
The nonlinear behavior of higher dimensional black hole spacetimes is of interest in several contexts, ranging from an understanding of cosmic censorship to black hole production in high-energy collisions.
Cardoso, Vitor, Gualtieri, Leonardo, Herdeiro, Carlos, Okawa, Hirotada, Shibata, Masaru, Sperhake, Ulrich, Witek, Helvi, Zilhao, Miguel   +7 more
core   +3 more sources

Pharmacological Inhibition of the VCP/Proteasome Axis Rescues Photoreceptor Degeneration in RHO^P23H Rat Retinal Explants

Biomolecules, 2021
Rhodopsin (RHO) misfolding mutations are a common cause of the blinding disease autosomal dominant retinitis pigmentosa (adRP). The most prevalent mutation, RHOP23H, results in its misfolding and retention in the endoplasmic reticulum (ER).
Merve Sen, Oksana Kutsyr, Bowen Cao, Sylvia Bolz, Blanca Arango-Gonzalez, Marius Ueffing   +5 more
doaj   +1 more source

Self-Adjointness of Dirac Operators with Infinite Mass Boundary Conditions in Sectors

, 2018
This paper deals with the study of the two-dimensional Dirac operatorwith infinite mass boundary condition in a sector. We investigate the question ofself-adjointness depending on the aperture of the sector: when the sector is convexit is self-adjoint on
Ourmières-Bonafos, Thomas, Treust, Loïc Le   +1 more
core   +3 more sources

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Shuyu Li, Robert A. Spooner, Stuart C. H. Allen, Christopher P. Guise, Graham Ladds, Tina Schnöder, Manfred J. Schmitt, J. Michael Lord, Lynne M. Roberts, Thomas Sommer, Alcock F., Allen S., Allen S. C., Argent R. H., Arndt V., Bar-Nun S., Barlowe C., Bazirgan O. A., Bellisola G., Biederer T., Bordallo J., Caldwell S. R., Carroll S. M., Carvalho P., Chaddock J. A., Christianson J. C., Deeks E. D., Denic V., Di Cola A., Duden R., Elkabetz Y., Endo Y., Gaber R. F., Gauss R., Ghislain M., Gietz R. D., Gillece P., Graham T. R., Haynes C. M., Hazes B., Heiligenstein S., Heinemeyer W., Hitt R., Jarosch E., Jarosch E., Kaiser C. A., Kawaguchi S., Kim I., Kim Y., Knop M., Kohler A., Lipson C., Lord J. M., Marshall R. S., Mayerhofer P. U., Medicherla B., Metzger M. B., Meusser B., Nakatsukasa K., Nishikawa S. I., Rabinovich E., Rodighiero C., Rouiller I., Rubin D. M., Sharma N., Sikorski R. S., Simpson J. C., Simpson J. C., Spear E. D., Spooner R. A., Spooner R. A., Spooner R. A., Springer S., Taxis C., Vashist S., Vashist S., Vogel J. P., Wesche J., Wilson J. D., Xia Z., Ye Y., Ye Y.   +81 more
core   +1 more source

Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

eLife, 2021
UbiA prenyltransferase domain-containing protein-1 (UBIAD1) utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize the vitamin K2 subtype menaquinone-4. The prenyltransferase has emerged as a key regulator of sterol-accelerated, endoplasmic reticulum
Rania Elsabrouty, Youngah Jo, Seonghwan Hwang, Dong-Jae Jun, Russell A DeBose-Boyd   +4 more
doaj   +1 more source

On the mass radiated by coalescing black-hole binaries

, 2012
We derive an analytic phenomenological expression that predicts the final mass of the black-hole remnant resulting from the merger of a generic binary system of black holes on quasi-circular orbits.
Abbott, Acernese, Amaro-Seoane, Baker, Baker, Barausse, Berti, Buchman, Campanelli, Chu, E. Barausse, Gair, Gair, Herrmann, Kawamura, L. Rezzolla, Li, Lousto, Lovelace, Nagar, O'Neill, Pfeiffer, Pollney, Punturo, Rezzolla, Rezzolla, Sathyaprakash, Sesana, V. Morozova, van Meter   +29 more
core   +1 more source