Results 31 to 40 of about 17,002 (210)

Remodeling the proteostasis network to rescue glucocerebrosidase variants by inhibiting ER-associated degradation and enhancing ER folding. [PDF]

PLoS ONE, 2013
Gaucher's disease (GD) is characterized by loss of lysosomal glucocerebrosidase (GC) activity. Mutations in the gene encoding GC destabilize the protein's native folding leading to ER-associated degradation (ERAD) of the misfolded enzyme.
Fan Wang, Laura Segatori
doaj   +1 more source

THE ERADICATION OF MALARIA [PDF]

Southern Medical Journal, 1912
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openaire   +2 more sources

Eradication of tetanus [PDF]

British Medical Bulletin, 2015
El agente causante del tétanos, Clostridium tetani, está muy extendido en el medio ambiente en todo el mundo y no se puede erradicar. Para reducir el número de casos de tétanos, los esfuerzos se centran en la prevención mediante la vacunación y el cuidado de las heridas después de la exposición.
Louise Thwaites, Ha Thi Loan
openaire   +2 more sources

Dissecting the Mechanics of Hrd1 Mediated ERAD

, 2023
Approximately one-third of proteins fold within the endoplasmic reticulum (ER), and the ER employs several protein quality control systems to either refold or degrade misfolded proteins.
Peterson, Brian
core   +1 more source

Folding-competent and folding-defective forms of Ricin A chain have different fates following retrotranslocation from the endoplasmic reticulum [PDF]

, 2010
We report that a toxic polypeptide retaining the potential to refold upon dislocation from the endoplasmic reticulum (ER) to the cytosol (ricin A chain; RTA) and a misfolded version that cannot (termed RTAΔ), follow ER-associated degradation (ERAD ...
Ladds, Graham, Manfred J. Schmitt, Robert A. Spooner, Stuart C. H. Allen, Schmitt, Manfred J., Shuyu Li, Christopher P. Guise, Lord, J M, Allen, Stuart C. H., Li, Shuyu, Roberts, L. M. (Lynne M.), Allen, Stuart C H, Schnöder, Tina, Spooner, R A, Spooner, Robert A., Ladds, G, Roberts, R M, Tina Schnöder, Guise, C P, Schmitt, M J, Guise, Christopher P., Graham Ladds, Lord, Mike, Lynne M. Roberts, J. Michael Lord, Li, S, Schnoder, T   +26 more
core   +1 more source

Lipid-regulated degradation of HMG-CoA reductase and Insig-1 through distinct mechanisms in insect cells

Journal of Lipid Research, 2013
In mammalian cells, levels of the integral membrane proteins 3-hydroxy-3-methylglutaryl-CoA reductase and Insig-1 are controlled by lipid-regulated endoplasmic reticulum-associated degradation (ERAD).
Rebecca A. Faulkner, Andrew D. Nguyen, Youngah Jo, Russell A. DeBose-Boyd   +3 more
doaj   +1 more source

ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION (ERAD) IN THE LIVER [PDF]

, 2019
Recent literature has revolutionized our view on the patho-physiological importance and the underlying molecular mechanism of endoplasmic reticulum (ER)-associated degradation (ERAD) in health and disease.
Bhattacharya, Asmita
core   +1 more source

The H protein of attenuated canine distemper virus is degraded via endoplasmic reticulum-associated protein degradation

Frontiers in Veterinary Science, 2023
Canine distemper (CD) caused by canine distemper virus (CDV) is considered a highly contagious and acutely febrile disease in various animals around the world.
Wenjie Wang, Wenjie Wang, Zhenwei Bi, Yakun Liu, Xingxia Xia, Jing Qian, Yeping Tan, Jianjun Zhao, Suquan Song   +8 more
doaj   +1 more source

Role of endoplasmic-reticulum-associated protein degradation pathway in the virus infection cycle

Journal of Education, Health and Sport, 2017
Introduction: The endoplasmic-reticulum-associated protein degradation (ERAD) pathway plays an important role in maintaining intracellular homeostasis and primarily affects proteins that have not achieved correct post-translational conformation.
Tomasz Wandtke, Ewelina Wędrowska, Arkadiusz Goede, Paulina Owczarska, Elżbieta Piskorska, Piotr Kopiński   +5 more
doaj   +3 more sources

Eradication

Journal of Applied Logic, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +2 more sources