Results 11 to 20 of about 17,002 (210)
ERAD and How Viruses Exploit It [PDF]
Frontiers in Microbiology, 2014 Endoplasmic reticulum-associated degradation (ERAD) is a universally important process among eukaryotic cells. ERAD is necessary to preserve cell integrity since the accumulation of defective proteins results in diseases associated with neurological ...
Jaquelin eDudley +4 more
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ER-to-lysosome-associated degradation acts as failsafe mechanism upon ERAD dysfunction
EMBO ReportsThe endoplasmic reticulum (ER) produces proteins destined to organelles of the endocytic and secretory pathways, the plasma membrane, and the extracellular space.
Elisa Fasana +4 more
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SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer
iScience, 2022 Summary: Endoplasmic reticulum (ER) homeostasis has been implicated in the pathogenesis of various forms of cancer; however, our understanding of the role of ER quality control mechanisms in tumorigenesis remains incomplete.
Asmita Bhattacharya +9 more
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Enterovirus 71 protease 2Apro and 3Cpro differentially inhibit the cellular endoplasmic reticulum-associated degradation (ERAD) pathway via distinct mechanisms, and enterovirus 71 hijacks ERAD component p97 to promote its replication. [PDF]
PLoS Pathogens, 2017 Endoplasmic reticulum-associated degradation (ERAD) is an important function for cellular homeostasis. The mechanism of how picornavirus infection interferes with ERAD remains unclear.
Tao Wang +10 more
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PLoS Biology, 2021 Endoplasmic reticulum-associated degradation (ERAD) is a protein quality control pathway of fundamental importance to cellular homeostasis. Although multiple ERAD pathways exist for targeting topologically distinct substrates, all pathways require ...
Christopher E Smith +15 more
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A pro-cathepsin L mutant is a luminal substrate for endoplasmic-reticulum-associated degradation in C. elegans. [PDF]
PLoS ONE, 2012 Endoplasmic-reticulum associated degradation (ERAD) is a major cellular misfolded protein disposal pathway that is well conserved from yeast to mammals. In yeast, a mutant of carboxypeptidase Y (CPY*) was found to be a luminal ER substrate and has served
Mark T Miedel +7 more
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Frontiers in Immunology, 2023 In Drosophila, the endoplasmic reticulum-associated protein degradation (ERAD) is engaged in regulating pleiotropic biological processes, with regard to retinal degeneration, intestinal homeostasis, and organismal development.
Yangyang Zhu +14 more
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HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation
iScience, 2020 Summary: ER-associated degradation (ERAD) targets misfolded ER proteins for degradation. Retrotranslocation, a key feature of ERAD, entails removal of ubiquitinated substrates into the cytosol for proteasomal destruction. Recently, it has been shown that
Sonya Neal +4 more
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UBE3C Facilitates the ER-Associated and Peripheral Degradation of Misfolded CFTR
Cells, 2023 The ubiquitin E3 ligase UBE3C promotes the proteasomal degradation of cytosolic proteins and endoplasmic reticulum (ER) membrane proteins. UBE3C is proposed to function downstream of the RNF185/MBRL ER-associated degradation (ERAD) branch, contributing ...
Yuka Kamada +7 more
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