Results 1 to 10 of about 9,109,989 (294)

Endoplasmic reticulum-associated degradation of glycoproteins in plants [PDF]

Frontiers in Plant Science, 2012
In all eukaryotes the endoplasmic reticulum (ER) has a central role in protein folding and maturation of secretory and membrane proteins. Upon translocation into the ER polypeptides are immediately subjected to folding and modifications involving the ...
Silvia eHüttner, Richard eStrasser
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AUP1 Regulates the Endoplasmic Reticulum-Associated Degradation and Polyubiquitination of NKCC2 [PDF]

Cells
Inactivating mutations of kidney Na-K-2Cl cotransporter NKCC2 lead to antenatal Bartter syndrome (BS) type 1, a life-threatening salt-losing tubulopathy.
Nadia Frachon, Sylvie Demaretz, Elie Seaayfan, Lydia Chelbi, Dalal Bakhos-Douaihy, Kamel Laghmani   +5 more
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Endoplasmic reticulum associated degradation preserves neurons viability by maintaining endoplasmic reticulum homeostasis [PDF]

Frontiers in Neuroscience
Endoplasmic reticulum-associated degradation (ERAD) is a principal quality-control mechanism responsible for targeting misfolded ER proteins for cytosolic degradation.
Shuangchan Wu, Shuangchan Wu, Pingting Liu, Pingting Liu, Marija Cvetanovic, Marija Cvetanovic, Wensheng Lin, Wensheng Lin   +7 more
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Endoplasmic reticulum-associated degradation mitigates atherosclerosis by maintaining cellular homeostasis [PDF]

Frontiers in Physiology
Atherosclerosis (AS) is a fatal cardiovascular disease (CVD) that threatens human health. Although there are some treatments for AS in clinical practice, cardiovascular complications such as myocardial ischemia and hypoxia, heart failure, and stroke ...
Haiming Niu, Lin Wu, Yingzhang Cai, Conghui Yu, Ning Lin, Xiaodong Cai, Miaolian Chen, Linli Wang, Linli Wang   +8 more
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Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection [PDF]

eLife, 2021
Signals from the pre-T cell receptor and Notch coordinately instruct β-selection of CD4–CD8–double negative (DN) thymocytes to generate αβ T cells in the thymus.
Xia Liu, Jingjing Yu, Longyong Xu, Katharine Umphred-Wilson, Fanglue Peng, Yao Ding, Brendan M Barton, Xiangdong Lv, Michael Y Zhao, Shengyi Sun, Yuning Hong, Ling Qi, Stanley Adoro, Xi Chen   +13 more
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Golgi Alpha1,2-Mannosidase IA Promotes Efficient Endoplasmic Reticulum-Associated Degradation of NKCC2 [PDF]

Cells, 2021
Mutations in the apically located kidney Na-K-2Cl cotransporter NKCC2 cause type I Bartter syndrome, a life-threatening kidney disorder. We previously showed that transport from the ER represents the limiting phase in NKCC2 journey to the cell surface ...
Sylvie Demaretz, Elie Seaayfan, Dalal Bakhos-Douaihy, Nadia Frachon, Martin Kömhoff, Kamel Laghmani   +5 more
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Gallic Acid Prevents the Oxidative and Endoplasmic Reticulum Stresses in the Hippocampus of Adult-Onset Hypothyroid Rats

Frontiers in Pharmacology, 2021
Thyroid hormone is essential for hippocampal redox environment and neuronal viability in adulthood, where its deficiency causes hypothyroidism related to oxidative and endoplasmic reticulum stresses in the hippocampus, resulting in neuronal death.
Vanessa Blas-Valdivia, Margarita Franco-Colín, Placido Rojas-Franco, Alberto Chao-Vazquez, Alberto Chao-Vazquez, Edgar Cano-Europa   +5 more
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EFFECT OF EDEM1 OVEREXPRESSION ON THE GENERATION AND ASSEMBLY OF MAJOR HISTOCOMPATIBILITY COMPLEXES [PDF]

Romanian Journal of Rheumatology, 2016
Background. A better understanding of the role of endoplasmic reticulum degradation-enhancing alpha-mannosidase – like protein 1 (EDEM1) in endoplasmic reticulum associated degradation (ERAD) may open new therapeutic approaches in autoimmune diseases ...
Alexandra Circiumaru, Gabriela Chiritoiu, Livia Sima, Mihai Bojinca, Stefana Petrescu   +4 more
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The Crucial Role of Demannosylating Asparagine-Linked Glycans in ERADicating Misfolded Glycoproteins in the Endoplasmic Reticulum

Frontiers in Plant Science, 2021
Most membrane and secreted proteins are glycosylated on certain asparagine (N) residues in the endoplasmic reticulum (ER), which is crucial for their correct folding and function.
Jianjun Zhang, Jianjun Zhang, Jiarui Wu, Jiarui Wu, Linchuan Liu, Linchuan Liu, Jianming Li, Jianming Li, Jianming Li   +8 more
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Translational balancing questioned: Unaltered glycosylation during disulfiram treatment in mannosyl‐oligosaccharide alpha‐1,2‐mannnosidase‐congenital disorders of glycosylation (MAN1B1‐CDG)

JIMD Reports, 2021
MAN1B1‐CDG is a multisystem disorder caused by mutations in MAN1B1, encoding the endoplasmic reticulum mannosyl‐oligosaccharide alpha‐1,2‐mannnosidase. A defect leads to dysfunction within the degradation of misfolded glycoproteins.
Lisa Kemme, Marianne Grüneberg, Janine Reunert, Stephan Rust, Julien Park, Cordula Westermann, Yoshinao Wada, Oliver Schwartz, Thorsten Marquardt   +8 more
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