Results 41 to 50 of about 9,109,989 (294)

The association of shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect [PDF]

, 2006
Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx).
Falguières, T, Platt, Frances M., Platt, Frances, Roberts, LM, Sillence, DJ, Smith, Daniel C., Jarvis, Rosemary M., Lord, JM, Smith, DC, Lord, J. Michael, Roberts, Lynne M., Jarvis, R. M., Sillence, Daniel J., Johannes, Ludger, Falguires, T., Falguières, Thomas, Lord, Mike, Johannes, L, Roberts, L. M. (Lynne M.), Jarvis, RM, Smith, D. C.   +20 more
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The Endoplasmic Reticulum-Associated Degradation Pathways of Budding Yeast [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Protein misfolding is a common cellular event that can produce intrinsically harmful products. To reduce the risk, quality control mechanisms are deployed to detect and eliminate misfolded, aggregated, and unassembled proteins. In the secretory pathway, it is mainly the endoplasmic reticulum-associated degradation (ERAD) pathways that perform this role.
Guillaume, Thibault, Davis T W, Ng
openaire   +2 more sources

Transcriptional analysis implicates endoplasmic reticulum stress in bovine spongiform encephalopathy. [PDF]

, 2010
Bovine spongiform encephalopathy (BSE) is a fatal, transmissible, neurodegenerative disease of cattle. To date, the disease process is still poorly understood.
Xiang, Wei, Hans A. Kretzschmar, Hans A Kretzschmar, Kretzschmar, Hans A., Yue Tang, Otto Windl, Terry, Linda, Windl, Otto, Tang, Yue, Linda Terry, Wei Xiang   +10 more
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One step at a time: endoplasmic reticulum-associated degradation [PDF]

Nature Reviews Molecular Cell Biology, 2008
Protein folding in the endoplasmic reticulum (ER) is monitored by ER quality control (ERQC) mechanisms. Proteins that pass ERQC criteria traffic to their final destinations through the secretory pathway, whereas non-native and unassembled subunits of multimeric proteins are degraded by the ER-associated degradation (ERAD) pathway.
Shruthi S, Vembar, Jeffrey L, Brodsky
openaire   +2 more sources

Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]

, 2011
Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga, Roger Whitehead, Helen Williams, Whitehead, Roger C., Robert A. Spooner, Flitsch, Sabine L., Swanton, Eileithyia, Stephen High, Pietroni, Paola, Eileithyia Swanton, Whitehead, Roger, Vidya Pawar, Sabine L. Flitsch, Sabine L Flitsch, Paola Pietroni, High, Stephen; id_orcid, J Michael Lord, Spooner, Robert A., Lord, J. Michael, McKibbin, Craig, Pawar, Vidya, Williams, Helen, Lord, Mike, Mina-Olga Aletrari, Robert A Spooner, Craig McKibbin, High, Stephen, J. Michael Lord, Aletrari, Mina Olga   +28 more
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Effects of oxidative stress on the solubility of HRD1, a ubiquitin ligase implicated in Alzheimer's disease.

PLoS ONE, 2014
The E3 ubiquitin ligase HRD1 is found in the endoplasmic reticulum membrane of brain neurons and is involved in endoplasmic reticulum-associated degradation. We previously demonstrated that suppression of HRD1 expression in neurons causes accumulation of
Ryo Saito, Masayuki Kaneko, Yoshihisa Kitamura, Kazuyuki Takata, Koichi Kawada, Yasunobu Okuma, Yasuyuki Nomura   +6 more
doaj   +1 more source

Endoplasmic Reticulum Quality Control in Immune Cells

Frontiers in Cell and Developmental Biology, 2021
The endoplasmic reticulum quality control (ERQC) system, including endoplasmic reticulum-associated degradation (ERAD), the unfolded protein response (UPR), and autophagy, presides over cellular protein secretion and maintains proteostasis in mammalian ...
Yalan Jiang, Zehua Tao, Hua Chen, Sheng Xia   +3 more
doaj   +1 more source

Sec61p is part of the endoplasmic reticulum‐associated degradation machinery [PDF]

The EMBO Journal, 2009
Endoplasmic reticulum-associated degradation (ERAD) is a cellular pathway for the disposal of misfolded secretory proteins. This process comprises recognition of the misfolded proteins followed by their retro-translocation across the ER membrane into the cytosol in which polyubiquitination and proteasomal degradation occur. A variety of data imply that
Antje, Schäfer, Dieter H, Wolf
openaire   +2 more sources

The isolation and characterisation of temperature-dependent Ricin A chain molecules in Saccharomyces cerevisiae. [PDF]

, 2007
Ricin is a heterodimeric plant protein that is potently toxic to mammalian cells. Toxicity results from the catalytic depurination of eukaryotic ribosomes by ricin A chain (RTA) that follows toxin endocytosis to, and translocation across, the ...
Ladds, Graham, Moffat, K G, Allen, Stuart C H, Fulop, V, Moore, Katherine A. H., Marsden, Catherine J., Marsden, C J, Ladds, G, Roberts, L M, Lord, Mike, Lord, J M, Allen, Stuart C. H., Roberts, L. M. (Lynne M.), Moffat, Kevin G., Fülöp, Vilmos, Moore, K A H   +15 more
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The Sar1 GTPase coordinates biosynthetic cargo selection with endoplasmic reticulum export site assembly. [PDF]

, 2001
Cargo selection and export from the endoplasmic reticulum is mediated by the COPII coat machinery that includes the small GTPase Sar1 and the Sec23/24 and Sec13/31 complexes.
Bannykh, Sergei, Balch, WE, William E. Balch, Aridor, M, Balch, William E, Fish, KN, Lippincott-Schwartz, J, Fish, Kenneth N, Lippincott-Schwartz, Jennifer, Meir Aridor, Weissman, Jacques, Sergei Bannykh, Jacques Weissman, Bannykh, S, Roberts, Theresa H, Weissman, J, Aridor, Meir, Jennifer Lippincott-Schwartz, Roberts, TH, Theresa H. Roberts, Kenneth N. Fish   +20 more
core   +1 more source