Results 61 to 70 of about 9,109,989 (294)
Identification of ERAD-dependent degrons for the endoplasmic reticulum lumen
eLifeDegrons are minimal protein features that are sufficient to target proteins for degradation. In most cases, degrons allow recognition by components of the cytosolic ubiquitin proteasome system.
Rachel Sharninghausen +3 more
doaj +1 more source
The Cdc48 machine in endoplasmic reticulum associated protein degradation
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 The AAA-type ATPase Cdc48 (named p97/VCP in mammals) is a molecular machine in all eukaryotic cells that transforms ATP hydrolysis into mechanic power to unfold and pull proteins against physical forces, which make up a protein's structure and hold it in place.
Wolf, Dieter H., Stolz, Alexandra
openaire +2 more sources
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Endoplasmic reticulum H₂O₂ : Ero1-driven generation and GPx-mediated detoxification [PDF]
, 2014 Endoplasmic reticulum (ER) oxidoreductin 1 alpha (Ero1alpha) is an ER-resident oxidase, which utilizes molecular oxygen (O2) as terminal electron acceptor to produce disulfide bonds and hydrogen peroxide (H2O2).
Ramming, Thomas
core +1 more source
Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508 [PDF]
Molecular Biology of the Cell, 2008 Misfolded or improperly assembled proteins in the endoplasmic reticulum (ER) are exported into the cytosol and degraded via the ubiquitin–proteasome pathway, a process termed ER-associated degradation (ERAD). Saccharomyces cerevisiae Hrd1p/Der3p is an ER membrane-spanning ubiquitin ligase that participates in ERAD of the cystic fibrosis transmembrane ...
Daisuke, Morito +8 more
openaire +2 more sources
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Characterising the expression and interactions of the Endoplasmic Reticulum Oxidoreductase Erol β [PDF]
, 2006 Proteins destined for the secretory pathway and endoplasmic reticulum (ER) resident proteins are targeted to the ER through an N-terminal signal sequence. Proteins then follow a post-translational maturation process to fold into functional proteins.
Gunasekara, Sanjika Dias
core
Green fluorescent protein-based monitoring of endoplasmic reticulum redox poise [PDF]
, 2013 Pathological endoplasmic reticulum (ER) stress is tightly linked to the accumulation of reactive oxidants, which can be both upstream and downstream of ER stress.
Julia Birk +11 more
core +1 more source
Understanding the mammalian TRAP complex function(s) [PDF]
Open Biology, 2020 In eukaryotic cells, about one-third of the synthesized proteins are translocated into the endoplasmic reticulum; they are membrane or lumen resident proteins and proteins direct to the Golgi apparatus.
Antonietta Russo
doaj +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source