Results 71 to 80 of about 9,109,989 (294)

The mutualistic fungus Piriformospora indica colonizes Arabidopsis roots by inducing an endoplasmic reticulum stress-triggered caspase-dependent cell death [PDF]

, 2012
In Arabidopsis thaliana roots, the mutualistic fungus Piriformospora indica initially colonizes living cells, which die as the colonization proceeds. We aimed to clarify the molecular basis of this colonization-associated cell death.
Zechmann, B., Kogel, Karl-Heinz, Schäfer, Patrick, Qiang, X., Reitz, M. U.   +4 more
core   +1 more source

NAA10 and BTRC drive CREBRF degradation in endoplasmic reticulum stress and renal tubular injury

Journal of Diabetes Investigation
Background Diabetic kidney disease (DKD) is a frequent complication associated with diabetes. CREBRF was reported to be closely associated with endoplasmic reticulum stress. However, the upstream regulatory mechanism by which CREBRF modulates endoplasmic
Sitian Fang, Jing Ning, Jinjing Huang, Yanxia Chen   +3 more
doaj   +1 more source

Endoplasmic reticulum stress in lung cancer

Frontiers in Oncology
Endoplasmic reticulum is the primary site of eukaryotic cells involved in biosynthesis, lipid metabolism, glucose metabolism, protein folding and secretion.
Donghuan Zhang, Lanlan Lin, Hui Jin, Huajun Mao, Luying Wang, Wenwen Ma, Zhenghong Lao   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

SGTA regulates the cytosolic quality control of hydrophobic substrates [PDF]

, 2014
Hydrophobic amino acids are normally shielded from the cytosol and their exposure is often used as an indicator of protein misfolding to enable the chaperone-mediated recognition and quality control of aberrant polypeptides.
Payapilly, Aishwarya, Leznicki, Pawel, High, Stephen; id_orcid, High, Stephen, Wunderley, Lydia   +4 more
core   +1 more source

Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Possible Involvement of HRD1, a Novel Molecule Related to Endoplasmic Reticulum Stress, in Alzheimer’s Disease

Journal of Pharmacological Sciences, 2012
Endoplasmic reticulum (ER)-associated degradation (ERAD) is a protective mechanism against ER stress in which unfolded proteins accumulated in the ER are selectively transported to the cytosol for degradation by the ubiquitin–proteasome system. We cloned
Masayuki Kaneko, Yasunobu Okuma, Yasuyuki Nomura   +2 more
doaj   +1 more source

Cholesterol Induces Pyroptosis and Matrix Degradation via mSREBP1-Driven Endoplasmic Reticulum Stress in Intervertebral Disc Degeneration

Frontiers in Cell and Developmental Biology, 2022
Intervertebral disc degeneration (IDD) is closely associated with low back pain, but its underlying mechanism remains unclear. Cholesterol is an essential nutrient in mammalian cells.
Jiansen Yan, Jiansen Yan, Shuangxing Li, Shuangxing Li, Yangyang Zhang, Yangyang Zhang, Zhihuai Deng, Zhihuai Deng, Jiajun Wu, Jiajun Wu, Zhengqi Huang, Zhengqi Huang, Tianyu Qin, Tianyu Qin, Yin Xiao, Yin Xiao, Jie Zhou, Jie Zhou, Kang Xu, Kang Xu, Wei Ye, Wei Ye   +21 more
doaj   +1 more source

Identification of SVIP as an Endogenous Inhibitor of Endoplasmic Reticulum-associated Degradation [PDF]

Journal of Biological Chemistry, 2007
Misfolded proteins in the endoplasmic reticulum (ER) are eliminated by a process known as ER-associated degradation (ERAD), which starts with misfolded protein recognition, followed by ubiquitination, retrotranslocation to the cytosol, deglycosylation, and targeting to the proteasome for degradation.
Petek, Ballar, Yongwang, Zhong, Masami, Nagahama, Mitsuo, Tagaya, Yuxian, Shen, Shengyun, Fang   +5 more
openaire   +2 more sources

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Inhibition of cellular protein secretion by norwalk virus nonstructural protein p22 requires a mimic of an endoplasmic reticulum export signal. [PDF]

, 2010
Protein trafficking between the endoplasmic reticulum (ER) and Golgi apparatus is central to cellular homeostasis. ER export signals are utilized by a subset of proteins to rapidly exit the ER by direct uptake into COPII vesicles for transport to the ...
Sue E Crawford, Mary K Estes, Mary K. Estes, Susana Guix, Kazuhiko Katayama, Sue E. Crawford, Tyler M Sharp, Tyler M. Sharp, Guix Arnau, Susana, Katayama, K., Guix Susana, Crawford, Sue E., Estes, M. K., Katayama Kazuhiko, Estes Mary K., Sharp, T. M., Sharp Tyler M., Crawford Sue E.   +17 more
core   +3 more sources