Results 91 to 100 of about 9,109,989 (294)

The Emp24 complex recruits a specific cargo molecule into endoplasmic reticulum-derived vesicles [PDF]

, 2000
Members of the yeast p24 family, including Emp24p and Erv25p, form a heteromeric complex required for the efficient transport of selected proteins from the endoplasmic reticulum (ER) to the Golgi apparatus.
Muñiz Guinea, Manuel, Riezman, Howard, Howard Riezman, Claude Nuoffer, Nuoffer, Claude, Nuoffer, C., Riezman, H., Muniz, M., Hauri, Hans Peter, Manuel Muñiz, Hauri, H. P., Hans-Peter Hauri   +11 more
core   +1 more source

PAWH1 and PAWH2 are plant-specific components of an Arabidopsis endoplasmic reticulum-associated degradation complex

Nature Communications, 2019
Endoplasmic reticulum (ER)-associated degradation (ERAD) removes misfolded proteins from the secretory pathway. Here the authors identify two plant-specific proteins in Arabidopsis, PAWH1 and PAWH2, that bind to and stabilise the ER-anchored ubiquitin ...
Liangguang Lin, Congcong Zhang, Yongwu Chen, Yi Wang, Dinghe Wang, Xiaolei Liu, Muyang Wang, Juan Mao, Jianjun Zhang, Weiman Xing, Linchuan Liu, Jianming Li   +11 more
doaj   +1 more source

Recent advances in the understanding of autophagosome biogenesis [version 1; peer review: 2 approved]

F1000Research, 2020
Autophagy is a conserved catabolic process critical for cell homeostasis with broad implications for aging and age-associated diseases. A defining feature of autophagy is the de novo formation of a specialized transient organelle, the double-membrane ...
Martin Graef
doaj   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Nuclear receptor LRH-1/NR5A2 is required and targetable for liver endoplasmic reticulum stress resolution [PDF]

, 2014
Chronic endoplasmic reticulum (ER) stress results in toxicity that contributes to multiple human disorders. We report a stress resolution pathway initiated by the nuclear receptor LRH-1 that is independent of known unfolded protein response (UPR ...
DeMayo, Fransesco J., San-Pin Wu, David D Moore, Moore, David D, Whitby, Richard J., Martin Wagner, Moore, David D., Peter J Stambrook, Whitby, Richard J, Sifers, Richard N, Ming-Jer Tsai, Francesco J DeMayo, Wu, San-pin, Mamrosh, Jennifer L, Jennifer L Mamrosh, Lee, Jae Man, Sifers, Richard N., Richard N Sifers, Richard J Whitby, Stambrook, Peter J, Stambrook, Peter J., Jae Man Lee, Wagner, Martin, Tsai, Ming-jer, Lee, Jae M., DeMayo, Francesco J, Mamrosh, Jennifer L.   +26 more
core   +1 more source

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source

Bidirectional crosstalk between endoplasmic reticulum stress and mTOR signaling [PDF]

, 2012
Many cellular processes including apoptosis, autophagy, translation, energy metabolism, and inflammation are controlled by the mammalian target of rapamycin (mTOR) kinase and the endoplasmic reticulum (ER) stress pathway, also known as the unfolded ...
Appenzeller-Herzog, Christian, Hall, Michael N.   +1 more
core   +1 more source

Purification and preparation of Marchantia polymorpha Auxin Response Factor 2 for phase separation studies

FEBS Open Bio, EarlyView.
We describe detailed protocols for the purification and preparation of Marchantia polymorpha Auxin Response Factor 2 (MpARF2). This protein is fused to an MBP solubility tag and an mNG fluorescent tag and is purified from Escherichia coli. The presented procedures make it possible to study MpARF2 assemblies, which could arise from phase separation ...
Bas Janssen, Robin Romein, Willy A. M. van den Berg, Simon Lindhoud, Jan Willem Borst, Carlo P. M. van Mierlo   +5 more
wiley   +1 more source

A Peroxisomal Lon Protease and Peroxisome Degradation by Autophagy Play Key Roles in Vitality of Hansenula polymorpha Cells [PDF]

, 2007
In eukaryote cells various mechanisms exist that are responsible for the removal of non-functional proteins. Here we show that in the yeast Hansenula polymorpha (H.
Jourdan, Stefanie, Kiel, Jan A.K.W., Klei, Ida J. van der; id_orcid, Bener Aksam, Eda, Veenhuis, Marten, Koek, Anne, Klei, Ida J. van der   +6 more
core   +2 more sources

Targeting the calcium ATPase to the endoplasmic reticulum

, 2009
The sarco/endoplasmic reticulum calcium ATPase (SERCA) pumps calcium from thecytoplasm into the lumen of the endoplasmic or sarcoplasmic reticulum (ER/SR), removingexcess Ca2+ from the cytoplasm and replenishing ER/SR Ca2+ stores. SERCA is located inboth
Watson, Helen Rachel
core   +1 more source