Results 101 to 110 of about 9,109,989 (294)

The endoplasmic reticulum-associated degradation is necessary for plant salt tolerance [PDF]

Cell Research, 2010
Eukaryotic organisms have quality-control mechanisms that allow misfolded or unassembled proteins to be retained in the endoplasmic reticulum (ER) and subsequently degraded by ER-associated degradation (ERAD). The ERAD pathway is well studied in yeast and mammals; however, the biological functions of plant ERAD have not been reported. Through molecular
Lijing, Liu, Feng, Cui, Qingliang, Li, Bojiao, Yin, Huawei, Zhang, Baoying, Lin, Yaorong, Wu, Ran, Xia, Sanyuan, Tang, Qi, Xie   +9 more
openaire   +2 more sources

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Transmembrane domain length is responsible for the ability of a plant reticulon to shape endoplasmic reticulum tubules in vivo [PDF]

, 2010
Reticulons are integral endoplasmic reticulum (ER) membrane proteins that have the ability to shape the ER into tubules. It has been hypothesized that their unusually long conserved hydrophobic regions cause reticulons to assume a wedge-like topology ...
Eastmond, Peter J., Hawes, Chris, Craddock, Christian P., Peter J. Eastmond, Eastmond, Peter J, Tolley, Nicholas, Hawes, C. R., Frigerio, Lorenzo, John Runions, Craddock, Christian P, Lorenzo Frigerio, Nicholas Tolley, Christian P. Craddock, Chris Hawes, Runions, John, Imogen Sparkes, Sparkes, Imogen   +16 more
core   +1 more source

The ERN1 signaling pathway of unfolded protein controls the expression of EDEM1 and its hypoxic regulation in glioblastoma cells

Endocrine Regulations
Objective. For the effective growth of malignant tumors, including glioblastoma, the necessary factors involve endoplasmic reticulum (ER) stress, hypoxia, and the availability of nutrients, particularly glucose.
Minchenko Oleksandr H., Hrebennykova Vita O., Viletska Yuliia M., Hnatiuk Oksana S., Sliusar Myroslava Y., Kozynkevych Halyna E., Minchenko Dmytro O.   +6 more
doaj   +1 more source

Unfolded protein response and activated degradative pathways regulation in GNE myopathy.

PLoS ONE, 2013
Although intracellular beta amyloid (Aβ) accumulation is known as an early upstream event in the degenerative course of UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) myopathy, the process by which Aβdeposits initiate various ...
Honghao Li, Qi Chen, Fuchen Liu, Xuemei Zhang, Wei Li, Shuping Liu, Yuying Zhao, Yaoqin Gong, Chuanzhu Yan   +8 more
doaj   +1 more source

Lipid Droplet Formation Is Dispensable for Endoplasmic Reticulum-associated Degradation [PDF]

Journal of Biological Chemistry, 2011
Proteins that fail to fold or assemble in the endoplasmic reticulum (ER) are destroyed by cytoplasmic proteasomes through a process known as ER-associated degradation. Substrates of this pathway are initially sequestered within the ER lumen and must therefore be dislocated across the ER membrane to be degraded.
James A, Olzmann, Ron R, Kopito
openaire   +2 more sources

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Endoplasmic reticulum degradation–enhancing α-mannosidase–like protein 1 targets misfolded HLA–B27 dimers for endoplasmic reticulum–associated degradation [PDF]

, 2014
H.F is supported by an Arthritis Research (AR) UK project grant (17222). I.L is supported by ARUK studentship (17868) A.N.A is supported by an ARUK Fellowship (15293). E.C.C is supported by the Chief Scientist Office of the Scottish Government. D.N.H. is
Fletcher, Adam J, Lenart, Izabela, Powis, Simon J, Hebert, Daniel, Hebert, Daniel N., Towers, G.J., Tsao, E., Lenart, I., Powis, S.J., Gould, Keith G., Towers, Greg J, Antoniou, Antony N., Daniel N. Hebert, Campbell, Elaine C., David B. Guiliano, Fletcher, A.J., Cameron, Amy, Powis, Simon J., Adam J. Fletcher, Gould, Keith G, Campbell, E.C., Fussell, H., Izabela Lenart, Powis, Simon, Antoniou, Antony, Susana Santos, Antoniou, Antony N, Guiliano, David, Antoniou, A.N., Keith G. Gould, Hebert, D.N., Amy Cameron, Guiliano, D.B., Tsao, Edward, Nasim Yousaf, Kellam, P., Cameron, A., Paul Kellam, Towers, Greg, Campbell, Elaine C, Simon J. Powis, Elaine C. Campbell, Yousaf, N., Hebert, Daniel N, Santos, Susana, Darren Nesbeth, Fussell, Helen, Guiliano, David B., Gould, K.G., Williams, S., Edward Tsao, Sarah Williams, Williams, Sarah, Towers, Greg J., Antony N. Antoniou, Fletcher, Adam, Santos, S., Greg J. Towers, Fletcher, Adam J., Yousaf, Nasim, Nesbeth, Darren, Kellam, Paul, Helen Fussell, Gould, Keith, Guiliano, David B, Nesbeth, D.   +65 more
core   +1 more source

Cyclophilin C Participates in the US2-Mediated Degradation of Major Histocompatibility Complex Class I Molecules.

PLoS ONE, 2015
Human cytomegalovirus uses a variety of mechanisms to evade immune recognition through major histocompatibility complex class I molecules. One mechanism mediated by the immunoevasin protein US2 causes rapid disposal of newly synthesized class I molecules
Daniel C Chapman, Pawel Stocki, David B Williams   +2 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source