Results 81 to 90 of about 9,109,989 (294)

Differential Expression and Function of SVIP in Breast Cancer Cell Lines and In Silico Analysis of Its Expression and Prognostic Potential in Human Breast Cancer

Cells, 2023
The heterogeneity of cancer strongly suggests the need to explore additional pathways to target. As cancer cells have increased proteotoxic stress, targeting proteotoxic stress-related pathways such as endoplasmic reticulum stress is attracting attention
Esra Atalay Şahar, Petek Ballar Kirmizibayrak   +1 more
doaj   +1 more source

Endoplasmic Reticulum-Associated Degradation (ERAD)

, 2019
يتم الاحتفاظ بالبروتينات المصنعة حديثًا في الشبكة الإندوبلازمية (ER) حتى اكتمال نضجها. يعد طي البروتين الدقيق أمرًا حيويًا لتحقيق التوازن، ولكن هذه العملية عرضة للخطأ لأنها معقدة كيميائيًا. قد يؤدي الطي الخفيف إلى وجود تكتسب الركام وظيفة سامة أو قد يؤدي إلى فقدان وظيفة البروتين ؛ لذلك، يمكن أن يؤدي طي البروتين إلى العديد من الأمراض.
Burcu Erbaykent Tepedelen, Petek Ballar
openaire   +2 more sources

Defining the Glycan Destruction Signal for Endoplasmic Reticulum-Associated Degradation [PDF]

Molecular Cell, 2008
The endoplasmic reticulum (ER) must target potentially toxic misfolded proteins for retrotranslocation and proteasomal degradation while avoiding destruction of productive folding intermediates. For luminal proteins, this discrimination typically depends not only on the folding status of a polypeptide, but also on its glycosylation state.
Quan, Erin M., Kamiya, Yukiko, Kamiya, Daiki, Denic, Vladimir, Weibezahn, Jimena, Kato, Koichi, Weissman, Jonathan S.   +6 more
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells [PDF]

, 2009
When the catalytic A subunits of the castor bean toxins ricin and Ricinus communis agglutinin (denoted as RTA and RCA A, respectively) are delivered into the endoplasmic reticulum (ER) of tobacco protoplasts, they become substrates for ER ...
Jolliffe, Nicholas A., Ceriotti, Aldo, Snowden, Christopher J., Lord, Mike, Roberts, L. M. (Lynne M.), Marshall, Richard S., Frigerio, Lorenzo   +6 more
core   +1 more source

Tetrahydrohyperforin Inhibits the Proteolytic Processing of Amyloid Precursor Protein and Enhances Its Degradation by Atg5-Dependent Autophagy. [PDF]

PLoS ONE, 2015
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β (Aβ) peptide. We have previously shown that the compound tetrahydrohyperforin (IDN5706) prevents accumulation of Aβ species in an in vivo model of AD,
Viviana A Cavieres, Alexis González, Vanessa C Muñoz, Claudia P Yefi, Hianara A Bustamante, Rafael R Barraza, Cheril Tapia-Rojas, Carola Otth, María José Barrera, Carlos González, Gonzalo A Mardones, Nibaldo C Inestrosa, Patricia V Burgos   +12 more
doaj   +1 more source

The Impact of Glycoengineering on the Endoplasmic Reticulum Quality Control System in Yeasts

Frontiers in Molecular Biosciences, 2022
Yeasts are widely used and established production hosts for biopharmaceuticals. Despite of tremendous advances on creating human-type N-glycosylation, N-glycosylated biopharmaceuticals manufactured with yeasts are missing on the market.
Mari A. Piirainen, Alexander D. Frey, Alexander D. Frey   +2 more
doaj   +1 more source

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation [PDF]

Trends in Cell Biology, 2017
Many human diseases are associated with mutations causing protein misfolding and aggregation in the endoplasmic reticulum (ER). ER-associated degradation (ERAD) is a principal quality-control mechanism responsible for targeting misfolded ER proteins for cytosolic degradation.
Ling, Qi, Billy, Tsai, Peter, Arvan
openaire   +2 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source