The ERAD system is restricted by elevated ceramides [PDF]
, 2023 Misfolded proteins in the endoplasmic reticulum (ER) are removed through a process known as ER-associated degradation (ERAD). ERAD occurs through an integral membrane protein quality control system that recognizes substrates, retrotranslocates the ...
Peterson, Brian +5 more
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Usa1 protein facilitates substrate ubiquitylation through two separate domains. [PDF]
PLoS ONE, 2009 BACKGROUND:Defects in protein folding are recognized as the root of many neurodegenerative disorders. In the endoplasmic reticulum (ER), secretory proteins are subjected to a stringent quality control process to eliminate misfolded proteins by the ER ...
Ikjin Kim +3 more
doaj +1 more source
Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways [PDF]
, 2011 Background: The small molecule Eeyarestatin I (ESI) inhibits the endoplasmic reticulum (ER)-cytosol dislocation and subsequent degradation of ERAD (ER associated protein degradation) substrates.
Aletrari, Mina-Olga +28 more
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Control of Protein Homeostasis in the Early Secretory Pathway: Current Status and Challenges
Cells, 2019 : Discrimination between properly folded proteins and those that do not reach this state is necessary for cells to achieve functionality. Eukaryotic cells have evolved several mechanisms to ensure secretory protein quality control, which allows ...
Daria Sicari, Aeid Igbaria, Eric Chevet
doaj +1 more source
Cytosolic entry of Shiga-like toxin A chain from the yeast endoplasmic reticulum requires catalytically active Hrd1p [PDF]
, 2012 Background Escherichia coli Shiga-like toxin 1 normally traffics to the endoplasmic reticulum (ER) in sensitive mammalian cells from where the catalytic A chain (SLTxA1) dislocates to the cytosol to inactivate ribosomes.
Lynne M. Roberts (150050) +21 more
core +2 more sources
Regulation of inner nuclear membrane associated protein degradation
Nucleus, 2019 The nucleus is enclosed by a double-membrane structure, the nuclear envelope, which separates the nucleoplasm from the cytoplasm. The outer nuclear membrane is continuous with the endoplasmic reticulum (ER), whereas the inner nuclear membrane (INM) is a ...
Bailey Koch, Hong-Guo Yu
doaj +1 more source
COP I and II dependent trafficking controls ER-associated degradation in mammalian cells
iScience, 2023 Summary: Misfolded proteins and components of the endoplasmic reticulum (ER) quality control and ER associated degradation (ERAD) machineries concentrate in mammalian cells in the pericentriolar ER-derived quality control compartment (ERQC), suggesting ...
Navit Ogen-Shtern +6 more
doaj +1 more source
Augmented ERAD (ER-associated degradation) activity in chondrocytes is necessary for cartilage development and maintenance [PDF]
, 2022 Chondrocytes secrete massive extracellular matrix (ECM) molecules that are produced, folded, and modified in the endoplasmic reticulum (ER). Thus, the ER-associated degradation (ERAD) complex???which removes misfolded and unfolded proteins to maintain ...
Park, Tae Joo +14 more
core +2 more sources
Effect of Sec61 interaction with Mpd1 on endoplasmic reticulum-associated degradation.
PLoS ONE, 2019 Proteins that misfold in the endoplasmic reticulum (ER) are transported back to the cytosol for ER-associated degradation (ERAD). The Sec61 channel is one of the candidates for the retrograde transport conduit.
Fabio Pereira +5 more
doaj +1 more source
Pharmaceutics, 2020 While the success of dendritic cell (DC) vaccination largely depends on cross-presentation (CP) efficiency, the precise molecular mechanism of CP is not yet characterized.
Jun Imai, Sayaka Ohashi, Takahiro Sakai
doaj +1 more source