Results 61 to 70 of about 37,506 (169)

SGTA regulates the cytosolic quality control of hydrophobic substrates [PDF]

, 2014
Hydrophobic amino acids are normally shielded from the cytosol and their exposure is often used as an indicator of protein misfolding to enable the chaperone-mediated recognition and quality control of aberrant polypeptides.
High, Stephen, Leznicki, Pawel, Payapilly, Aishwarya, Wunderley, Lydia   +3 more
core   +4 more sources

A microscopic description of black hole evaporation via holography

, 2016
We propose a description of how a large, cold black hole (black zero-brane) in type IIA superstring theory evaporates into freely propagating D0-branes, by solving the dual gauge theory quantitatively.
Berkowitz, Evan, Hanada, Masanori, Maltz, Jonathan   +2 more
core   +1 more source

Eradicating Malaria

Science Progress, 2009
The renewed interest in malaria research and control is based on the intolerable toll this disease takes on young children and pregnant women in Africa and other vulnerable populations; 150 to 300 children die each hour from malaria amounting to 1 to 2 million deaths yearly.
openaire   +2 more sources

Schnyder corneal dystrophy-associated UBIAD1 inhibits ER-associated degradation of HMG CoA reductase in mice

eLife, 2019
Autosomal-dominant Schnyder corneal dystrophy (SCD) is characterized by corneal opacification owing to overaccumulation of cholesterol. SCD is caused by mutations in UBIAD1, which utilizes geranylgeranyl pyrophosphate (GGpp) to synthesize vitamin K2 ...
Youngah Jo, Jason S Hamilton, Seonghwan Hwang, Kristina Garland, Gennipher A Smith, Shan Su, Iris Fuentes, Sudha Neelam, Bonne M Thompson, Jeffrey G McDonald, Russell A DeBose-Boyd   +10 more
doaj   +1 more source

Two-temperature Steady State Thermodynamics for a Radiation Field

, 2005
A candidate for a consistent steady state thermodynamics is constructed for a radiation field in vacuum sandwiched by two black bodies of different temperatures.
Bekkenstein, Bekkenstein, Binney, Dominguez-Cascante, Essex, Essex, Fort, Fort, Hawking, Hiromi Saida, Jou, Kim, Kim, Kippenhahn, Kondepudi, Landau, Ore, Rosen, Wildt   +18 more
core   +1 more source

β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. [PDF]

, 2010
ObjectiveThe islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP).
Butler, Alexandra E, Butler, Peter C, Costes, Safia, Daval, Marie, Gurlo, Tatyana, Huang, Chang-jiang, Matveyenko, Aleksey V, Rizza, Robert A   +7 more
core   +2 more sources

Proteomic screens of SEL1L-HRD1 ER-associated degradation substrates reveal its role in glycosylphosphatidylinositol-anchored protein biogenesis

Nature Communications
Endoplasmic reticulum-associated degradation (ERAD) plays indispensable roles in many physiological processes; however, the nature of endogenous substrates remains largely elusive.
Xiaoqiong Wei, You Lu, Liangguang Leo Lin, Chengxin Zhang, Xinxin Chen, Siwen Wang, Shuangcheng Alivia Wu, Zexin Jason Li, Yujun Quan, Shengyi Sun, Ling Qi   +10 more
doaj   +1 more source

Close-limit analysis for head-on collision of two black holes in higher dimensions: Brill-Lindquist initial data

, 2005
Motivated by the TeV-scale gravity scenarios, we study gravitational radiation in the head-on collision of two black holes in higher dimensional spacetimes using a close-limit approximation. We prepare time-symmetric initial data sets for two black holes
E. W. Leaver, Hirotaka Yoshino, K. D. Kokkotas, L. Smarr, Masaru Shibata, P. D. D’Eath, Tetsuya Shiromizu   +6 more
core   +1 more source

Radiative observables for linearized gravity on asymptotically flat spacetimes and their boundary induced states [PDF]

, 2014
We discuss the quantization of linearized gravity on globally hyperbolic, asymptotically flat, vacuum spacetimes and the construction of distinguished states which are both of Hadamard form and invariant under the action of all bulk isometries.
Claudio Dappiaggi, Geroch R. P., Hooft G.'t, Hörmander L., Marco Benini, Simone Murro   +5 more
core   +2 more sources

Endoplasmic reticulum associated degradation preserves neurons viability by maintaining endoplasmic reticulum homeostasis

Frontiers in Neuroscience
Endoplasmic reticulum-associated degradation (ERAD) is a principal quality-control mechanism responsible for targeting misfolded ER proteins for cytosolic degradation.
Shuangchan Wu, Shuangchan Wu, Pingting Liu, Pingting Liu, Marija Cvetanovic, Marija Cvetanovic, Wensheng Lin, Wensheng Lin   +7 more
doaj   +1 more source