Results 81 to 90 of about 37,506 (169)

Vertical Structure and Turbulent Saturation Level in Fully Radiative Protoplanetary Disc Models

, 2010
We investigate a massive ($\varSigma \sim 10000 g cm^{-2}$ at 1 AU) protoplanetary disc model by means of 3D radiation magnetohydrodynamics simulations.
Flaig, M., Kissmann, R., Kley, W.
core   +1 more source

AUP1 Regulates the Endoplasmic Reticulum-Associated Degradation and Polyubiquitination of NKCC2

Cells
Inactivating mutations of kidney Na-K-2Cl cotransporter NKCC2 lead to antenatal Bartter syndrome (BS) type 1, a life-threatening salt-losing tubulopathy.
Nadia Frachon, Sylvie Demaretz, Elie Seaayfan, Lydia Chelbi, Dalal Bakhos-Douaihy, Kamel Laghmani   +5 more
doaj   +1 more source

SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD complex

Nature Communications
The SEL1L-HRD1 protein complex represents the most conserved branch of endoplasmic reticulum (ER)-associated degradation (ERAD). Despite recent advances in both mouse models and humans, in vivo evidence for the importance of SEL1L in the ERAD complex ...
Liangguang Leo Lin, Huilun Helen Wang, Brent Pederson, Xiaoqiong Wei, Mauricio Torres, You Lu, Zexin Jason Li, Xiaodan Liu, Hancheng Mao, Hui Wang, Linyao Elina Zhou, Zhen Zhao, Shengyi Sun, Ling Qi   +13 more
doaj   +1 more source

Eradication [PDF]

Science, 1980
openaire   +2 more sources

Hypomorphic human SEL1L and HRD1 variants uncouple multilayered ER-associated degradation machinery

The Journal of Clinical Investigation
The suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) complex of the endoplasmic reticulum–associated degradation (ERAD) machinery is a key cellular proteostasis pathway.
Katharine Umphred-Wilson, Stanley Adoro
doaj   +1 more source

Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD

Nature Communications
Impaired secretion of an essential blood coagulation factor fibrinogen leads to hepatic fibrinogen storage disease (HFSD), characterized by the presence of fibrinogen-positive inclusion bodies and hypofibrinogenemia.
Zhenfeng Song, Pattaraporn Thepsuwan, Woosuk Steve Hur, Mauricio Torres, Shuangcheng Alivia Wu, Xiaoqiong Wei, Nusrat Jahan Tushi, Juncheng Wei, Francesca Ferraresso, Adrienne W. Paton, James C. Paton, Ze Zheng, Kezhong Zhang, Deyu Fang, Christian J. Kastrup, Sunil Jaiman, Matthew James Flick, Shengyi Sun   +17 more
doaj   +1 more source

Eradicating chancroid.

Bulletin of the World Health Organization, 2001
Genital ulcers are important cofactors of HIV transmission in the countries most severely affected by HIV/AIDS. Chancroid is a common cause of genital ulcer in all 18 countries where adult HIV prevalence surpasses 8% and is rare in countries with low-level HIV epidemics.
openaire   +2 more sources

Hypomorphic variants of SEL1L-HRD1 ER-associated degradation are associated with neurodevelopmental disorders

The Journal of Clinical Investigation
Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associated ...
Huilun H. Wang, Liangguang L. Lin, Zexin J. Li, Xiaoqiong Wei, Omar Askander, Gerarda Cappuccio, Mais O. Hashem, Laurence Hubert, Arnold Munnich, Mashael Alqahtani, Qi Pang, Margit Burmeister, You Lu, Karine Poirier, Claude Besmond, Shengyi Sun, Nicola Brunetti-Pierri, Fowzan S. Alkuraya, Ling Qi   +18 more
doaj   +1 more source

Eradication

Journal of Applied Logic, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Smallpox Eradication [PDF]

Journal of the Royal Society of Medicine, 1981
openaire   +2 more sources