Results 91 to 100 of about 17,002 (210)
How viruses hijack the ERAD tuning machinery [PDF]
, 2019 An essential step during the intracellular life cycle of many positive-strand RNA viruses is the rearrangement of host cell membranes to generate membrane-bound replication platforms.
Bernasconi, Riccardo +2 more
core
Quality Control Autophagy Degrades Soluble ERAD-Resistant Conformers of the Misfolded Membrane Protein GnRHR [PDF]
, 2014 Molecular chaperones triage misfolded proteins via action as substrate selectors for quality control (QC) machines that fold or degrade clients. Herein, the endoplasmic reticulum (ER) associated Hsp40 JB12 is reported to participate in partitioning ...
Madden, Victoria J. +7 more
core +1 more source
Surface proteins, ERAD and antigenic variation in Trypanosoma brucei
, 2016 Variant surface glycoprotein (VSG) is central to antigenic variation in African trypanosomes. Although much prior work documents that VSG is efficiently synthesized and exported to the cell surface, it was recently claimed that 2–3 fold more is ...
Muratore, Katherine A +2 more
core +1 more source
EDEM2 and OS-9 are required for ER-associated degradation of non-glycosylated sonic hedgehog.
PLoS ONE, 2014 Misfolded proteins of the endoplasmic reticulum (ER) are eliminated by the ER-associated degradation (ERAD) in eukaryotes. In S. cerevisiae, ER-resident lectins mediate substrate recognition through bipartite signals consisting of an unfolded local ...
Hsiang-Yun Tang +4 more
doaj +1 more source
Cell specific ERAD rescue is C. elegans
, 2022 Endoplasmic Reticulum Associated Degradation (ERAD) is a key system for preventing the buildup of misfolded proteins. ERAD uses 3 classes of proteins, E1s, E2s, and E3s--in coordination to tag misfolded proteins, to signals for their degradation ...
Hulsey-Vincent, Heino
core
, 2015 A: Viable cell concentration at 37°C. B: Viable cell concentration at 33°C. ◆ Control culture; ■ Tunicamicyn culture; ▲ Tunicamicyn/ERAD-I culture; ● Tunicamicyn/ERAD-II culture.
Julio Berrios (547028) +7 more
core +1 more source
USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation
eLife, 2014 Physiological adaptation to proteotoxic stress in the endoplasmic reticulum (ER) requires retrotranslocation of misfolded proteins into the cytoplasm for ubiquitination and elimination by ER-associated degradation (ERAD).
Yanfen Liu +6 more
doaj +1 more source
How Viruses Hijack the ERAD Tuning Machinery
An essential step during the intracellular life cycle of many positive-strand RNA viruses is the rearrangement of host cell membranes to generate membrane-bound replication platforms.
Bernasconi, Riccardo +2 more
core +1 more source
Sel1L is Indispensable for Mammalian ERAD, ER Homeostasis and Survival
, 2013 Sel1L is an adaptor protein for the E3 ligase Hrd1 involved in endoplasmic reticulum-associated degradation (ERAD). Its physiological importance in mammalian ERAD, however, remains to be established.
Han, Xuemei +13 more
core +1 more source