Results 111 to 120 of about 17,002 (210)

Oligosaccharyltransferase Is Involved in Targeting to ER-Associated Degradation

Cells
Most membrane and secretory proteins undergo N-glycosylation, catalyzed by oligosaccharyltransferase (OST), a membrane-bound complex in the endoplasmic reticulum (ER).
Marina Shenkman, Navit Ogen-Shtern, Chaitanya Patel, Haddas Saad, Bella Groisman, Metsada Pasmanik-Chor, Sonya M. Schermann, Roman Körner, Gerardo Z. Lederkremer   +8 more
doaj   +1 more source

Regulation of hepatic inclusions and fibrinogen biogenesis by SEL1L-HRD1 ERAD

Nature Communications
Impaired secretion of an essential blood coagulation factor fibrinogen leads to hepatic fibrinogen storage disease (HFSD), characterized by the presence of fibrinogen-positive inclusion bodies and hypofibrinogenemia.
Zhenfeng Song, Pattaraporn Thepsuwan, Woosuk Steve Hur, Mauricio Torres, Shuangcheng Alivia Wu, Xiaoqiong Wei, Nusrat Jahan Tushi, Juncheng Wei, Francesca Ferraresso, Adrienne W. Paton, James C. Paton, Ze Zheng, Kezhong Zhang, Deyu Fang, Christian J. Kastrup, Sunil Jaiman, Matthew James Flick, Shengyi Sun   +17 more
doaj   +1 more source

Smallpox Eradication [PDF]

Journal of the Royal Society of Medicine, 1981
openaire   +2 more sources

ERAD of proteins containing aberrant transmembrane domains requires ubiquitination of cytoplasmic lysine residues

, 2015
Clearance of misfolded proteins from the endoplasmic reticulum (ER) is mediated by the ubiquitin-proteasome system in a process known as ER-associated degradation (ERAD). The mechanisms through which proteins containing aberrant transmembrane domains are
Koay, Yee Hui, Otsuka, Yuka, Swanton, Eileithyia, Briant, Kit   +3 more
core   +1 more source

Eradicating Polio [PDF]

New England Journal of Medicine, 2004
Heymann, David L, Aylward, R Bruce
openaire   +2 more sources

Eradication of Brucellosis [PDF]

BMJ, 1963
W R, KERR, J, RANKIN
openaire   +2 more sources

O-mannosylation of misfolded ER proteins promotes ERAD

Protein quality control (PQC) in the secretory pathway, a process critically linked to numerous human diseases, begins in the endoplasmic reticulum (ER) and involves ER-associated degradation (ERAD) of terminally misfolded proteins.
Lemus Rodríguez,Leticia, Goder, Veit, Meyer, Hadar, Rodriguez-Rosado, Ana, I., Schuldiner, Maya   +4 more
core   +1 more source

The Eradication of Tuberculosis

International Journal of Clinical Practice, 1962
openaire   +2 more sources

Decoding the impact of lipid saturation on ER signaling networks, ERSU, UPR, and ERAD. [PDF]

PLoS One
Li X, Niwa M.
europepmc   +1 more source

Hepatocyte-Specific Deficiency of Endoplasmic Reticulum-Associated Degradation Induces Coordinated Innate-Adaptive Immune Responses. [PDF]

Cells
Liu Q, Wang J, Zong H, Ma H, Li M, Wang M, Wu D, Zheng S, Wang H, Long Q.   +9 more
europepmc   +1 more source