Results 31 to 40 of about 272,340 (307)

Feasibility of conducting intradermal vaccination campaign with inactivated poliovirus vaccine using Tropis intradermal needle free injection system, Karachi, Pakistan

Heliyon, 2017
Background: Administration of intradermal fractional dose of inactivated poliovirus vaccine (fIPV) has proven to be safe and immunogenic; however, its intradermal application using needle and syringe is technically difficult and requires trained ...
Mohammad Tahir Yousafzai, Ali Faisal Saleem, Ondrej Mach, Attaullah Baig, Roland W. Sutter, Anita K.M. Zaidi   +5 more
doaj   +1 more source

Developing eradication investment cases for onchocerciasis, lymphatic filariasis, and human African trypanosomiasis : rationale and main challenges [PDF]

, 2013
An EIC is essentially an economic composite assessment in the broader meaning of economics, addressing thus all three fundamental economics questions. An EIC in fact answers: 1) the ‘‘What’’ question, that compares remaining in control mode versus moving
Steinmann, Peter, Marcel Tanner, Peter Steinmann, de Savigny, Don, Tediosi, Fabrizio, Fabrizio Tediosi, Don de Savigny, María Gloria Basáñez, Tanner, Marcel, Tediosi F, de Savigny D, Steinmann P, Tanner M   +12 more
core   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Polio transition in the African Region: progress, challenges and prospects for health systems integration

BMC Infectious Diseases
Background The Global Polio Eradication Initiative (GPEI) has made substantial progress towards global eradication of polio. As regions, including Africa, approach the final stages of this goal, countries must ensure that essential polio functions are ...
Terna Nomhwange, Samafilan Ainan, Modjirom Nduotabe, Usman Adamu, Ogonna Chinwike, Kennedy Adejoh, Sule Adamu, Christopher Kamugisha, Ticha Johnson, Casimir Manengu, Gedi Mohamed   +10 more
doaj   +1 more source

Epidemiology and genetic characterization of orphan polioviruses in Africa, 2022–2024: Unmasking silent transmission and implications for eradication

Vaccine: X
Background: The continued detection of orphan polioviruses, defined by ≥ 1.5 % nucleotide divergence in the VP1-coding region of the virus compared with the VP1 of previous circulating isolates, presents a significant challenge to polio eradication ...
Brook Tesfaye, Julius E. Chia, Terna Nomhwange, D. Collins Owuor, Ticha Johnson Muluh, Safdar Nosheen, Arthur Yannick Doungmo Wakem, Abdullateef Jimoh, Akif Saatcioglu, Kebba Touray, Abdulahi Walla Hamisu, Modjirom Ndoutabe, Jamal A. Ahmed, Anfumbom Kfutwah   +13 more
doaj   +1 more source

Poliovirus excretion among children with primary immune deficiency in Pakistan: a pilot surveillance study protocol

BMJ Open, 2021
Introduction Children with primary immunodeficiency disorders (PID) are more susceptible to developing viral infections and are at a substantially increased risk of developing paralytic poliomyelitis.
Ali Faisal Saleem, Asma Sadruddin Pethani, Zaubina Kazi, Ujala Nayyar, Muhammad Shafiq-ur-Rehman, Muhammad Tahir Yousafzai, Mach Ondrej   +6 more
doaj   +1 more source

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

Molecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis, Tereza Buchtová, Jirina Bartkova, Marie Lund Bay, Christoffer Lynge Halvorsen, Zuzana Machacova, Zdenek Skrott, Martin Mistrik, Ekaterina Dulina, Miguel Andujar‐Sanchez, Estrid Høgdall, Tine Henrichsen Schnack, Claus Høgdall, Berit Jul Mosgaard, Marie Boennelycke, Jacob Brink Laursen, Allan Jensen, Susanne K. Kjær, Tuula Kallunki, Robert Strauss, Jiri Bartek   +20 more
wiley   +1 more source

Chromatin compartment shifting is recurrent and associated with epigenetic reprogramming in prostate cancer

iScience
Summary: Three-dimensional chromatin organization shapes gene regulation by partitioning the genome into transcriptionally active and inactive compartments, with implications for prostate carcinogenesis.
Tuomo Virtanen, Ebrahim Afyounian, Riikka Nurminen, Joonas Uusi-Mäkelä, Antti Kiviaho, Joonatan Sipola, Francesco Tabaro, Juha Kesseli, Teuvo Tammela, Teemu J. Murtola, Alfonso Urbanucci, Tapio Visakorpi, Kirsi Rautajoki, Matti Nykter   +13 more
doaj   +1 more source

Present Status of Malaria in Nepal

Journal of Nepal Medical Association, 2003
NA
G M Sakya
doaj   +1 more source