Results 1 to 10 of about 186,209 (139)

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease. [PDF]

PLoS ONE, 2019
Alzheimer's disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Deborah A Roby, Fernanda Ruiz, Bailey A Kermath, Jaymie R Voorhees, Michael Niehoff, Jinsong Zhang, John E Morley, Erik S Musiek, Susan A Farr, Thomas P Burris   +9 more
doaj   +4 more sources

Altered clock gene expression in obese visceral adipose tissue is associated with metabolic syndrome. [PDF]

PLoS ONE, 2014
Clock gene expression was associated with different components of metabolic syndrome (MS) in human adipose tissue. However, no study has been done to compare the expression of clock genes in visceral adipose tissue (VAT) from lean and obese subjects and ...
Elaine Vieira, Elena g Ruano, Ana Lucia C Figueroa, Gloria Aranda, Dulce Momblan, Francesc Carmona, Ramon Gomis, Josep Vidal, Felicia A Hanzu   +8 more
doaj   +3 more sources

Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors [PDF]

Cell Reports
Summary: REV-ERB nuclear receptors are integrated into the molecular circadian clock present in most mammalian cells. Loss of REV-ERBs (REV-ERB DKO) within the suprachiasmatic nucleus (SCN) in vivo leads to a marked shortening of the circadian period ...
Michael C. Tackenberg, Kristina M. Heliodoro, Lily C. Melink, Yifan Liu, Kun Zhu, Mitchell A. Lazar   +5 more
doaj   +2 more sources

CAN SOCIAL MEDIA BE A TOOL FOR INCREASING TOURISTS’ ENVIRONMENTALLY RESPONSIBLE BEHAVIOR? [PDF]

Geo Journal of Tourism and Geosites, 2021
For the sustainable development of a tourism destination, environmentally responsible behavior (ERB) is a vital issue. This study developed an implicated model based on the Stimulus-Organism-Response (S-O-R) framework showing the usages of social media
Enamul HAQUE, Tinikan SUNGSUWAN, Sarunya SANGLIMSUWAN   +2 more
doaj   +1 more source

Risk factors of major intraoperative bleeding and postoperative bleeding associated with endoscopic submucosal dissection for gastric neoplasms

Chinese Medical Journal, 2022
. Background:. Endoscopic resection bleeding (ERB) classification was proposed by the authors’ team to evaluate the severity of intraoperative bleeding (IB) during endoscopic submucosal dissection (ESD).
Shanshan Xu, Ningli Chai, Xiaowei Tang, Enqiang Linghu, Shasha Wang, Yuanyuan Ji   +5 more
doaj   +1 more source

REV-ERB is essential in cardiac fibroblasts homeostasis

Frontiers in Pharmacology, 2022
REV-ERB agonists have shown antifibrotic effects in the heart and other organs. The function of REV-ERB in the cardiac fibroblasts remains unstudied. Here, we characterize the functional difference of REV-ERB in mouse embryonic fibroblasts and cardiac ...
Xiaokang Luo, Shiyang Song, Lei Qi, Chih-Liang Tien, Hui Li, Weiyi Xu, Theodore Lemuel Mathuram, Thomas Burris, Yuanbiao Zhao, Zheng Sun, Zheng Sun, Lilei Zhang   +11 more
doaj   +1 more source

SR9009 improves heart function after pressure overload independent of cardiac REV-ERB

Frontiers in Cardiovascular Medicine, 2022
The core clock component REV-ERB is essential for heart function. Previous studies show that REV-ERB agonist SR9009 ameliorates heart remodeling in the pressure overload model with transverse aortic constriction (TAC).
Hui Li, Shiyang Song, Chih-liang Tien, Lei Qi, Andrea Graves, Eleni Nasiotis, Thomas P. Burris, Yuanbiao Zhao, Zheng Sun, Zheng Sun, Lilei Zhang   +10 more
doaj   +1 more source

Eribulin mesylate exerts antitumor effects via CD103

OncoImmunology, 2023
Eribulin mesylate (ERB) is a synthetic analog of halichondrin B, inhibiting tumor cell growth by disrupting microtubule function. Recently, anticancer drugs have been shown to not only act directly on tumor cells but also to exert antitumor effects by ...
Kazumasa Oya, Yoshiyuki Nakamura, Rei Watanabe, Ryota Tanaka, Yuki Ichimura, Noriko Kubota, Yutaka Matsumura, Hideaki Tahara, Naoko Okiyama, Manabu Fujimoto, Toshifumi Nomura, Yasuhiro Fujisawa   +11 more
doaj   +1 more source

Is an Endorectal Balloon Beneficial for Rectal Sparing after Spacer Implantation in Prostate Cancer Patients Treated with Hypofractionated Intensity-Modulated Proton Beam Therapy? A Dosimetric and Radiobiological Comparison Study

Current Oncology, 2023
Background: The aim of this study is to examine the dosimetric influence of endorectal balloons (ERB) on rectal sparing in prostate cancer patients with implanted hydrogel rectum spacers treated with dose-escalated or hypofractionated intensity-modulated
Dalia Ahmad Khalil, Jörg Wulff, Danny Jazmati, Dirk Geismar, Christian Bäumer, Paul-Heinz Kramer, Theresa Steinmeier, Stefanie Schulze Schleithoff, Stephan Tschirdewahn, Boris Hadaschik, Beate Timmermann   +10 more
doaj   +1 more source

Does Soundscape Perception Lead to Environmentally Responsible Behavior? A Case Study in Longcanggou Forest Park, China

Land, 2022
Soundscape perception (SP) plays an important role in promoting tourist-place interaction and enhancing tourists’ environmentally responsible behavior (ERB).
Nian Li, Ya Wen, Yanxin Wang, Yifei Li, Qibing Chen, Xi Li, Bingyang Lv   +6 more
doaj   +1 more source