Results 41 to 50 of about 39,620 (261)

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease.

PLoS ONE, 2019
Alzheimer's disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Deborah A Roby, Fernanda Ruiz, Bailey A Kermath, Jaymie R Voorhees, Michael Niehoff, Jinsong Zhang, John E Morley, Erik S Musiek, Susan A Farr, Thomas P Burris   +9 more
doaj   +1 more source

Melanoma Cells Exposed to Clomiphene Citrate Respond With Cell Cycle Arrest and Reduced Invasiveness

Journal of Applied Toxicology, EarlyView.
ABSTRACT Epidemiological studies have suggested that clomiphene citrate (CC) exposure may increase the risk of malignant melanoma, but mechanisms are unknown. We investigated the effects of CC on melanoma cell line A375. Cells were treated with CC at 2, 20, 200, and 2000 ng/mL, followed by assessment of cell viability and metabolism, cell cycle ...
Thaís S. Ribeiro, Felipe H. S. Silva, Ana Paula G. S. Miranda, Isabella T. Borges, Pedro H. D. M. Prazeres, Marcia C. F. Ferreira, Enio Ferreira, Fernando M. Reis, Helen L. Del Puerto   +8 more
wiley   +1 more source

Toxic Effects of Bisphenol A and Its Analogs on Ovarian Structure and Function: A Narrative Review of Ovary‐Focused Studies

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is a widely used industrial chemical found in polycarbonate plastics and epoxy resins and is recognized for its endocrine‐disrupting properties. Human exposure is common due to its presence in food packaging and everyday products. As BPA use has been restricted, structurally similar compounds such as BPS, BPB, BPAF, and BADGE
Nurbanu Zengin, Marwa Tawfıq Ahmed Alsalım, Muhammed Canik, Sevda Bağdatlı, Nazan Deniz Yön   +4 more
wiley   +1 more source

How Does Rural Tourscape Influence Tourists’ Environmentally Responsible Behavior? The Mediating Role of Nature Relatedness and Place Attachment

Agriculture
Tourists’ environmentally responsible behavior (ERB) is a key requirement in the promotion of the sustainable development of tourism destinations. Although extensive studies have explored the antecedents of tourists’ ERB, research within the context of ...
Kexin Cai, Yuqin Cheng, Joanna Fountain, Ling Guo, Biyang Fu, Hanyue Ni   +5 more
doaj   +1 more source

Deep‐Learning Based Contrast Boosting: A Multi‐Center Multi‐Reader Study on Clinical Performance With Standard Contrast Enhanced Brain MRI

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Gadolinium‐based contrast agents are used in brain MRI to improve the visualization of disorders and improve the delineation of lesions. Higher doses of GBCAs can improve lesion sensitivity but may have safety implications, particularly in light of recent findings on gadolinium retention and deposition.
Srivathsa Pasumarthi Venkata, Thomas Campbell Arnold, Sonia Colombo Serra, Jeffrey. D. Rudie, Jalal. B. Andre, Ronny Elor, Dayang Wang, Praveen Gulaka, Ajit Sankaranarayanan, Gunter Erb, Greg Zaharchuk   +10 more
wiley   +1 more source

Bromelain as the enzyme of the future: A global bibliometric mapping of its applications and emerging trends

Journal of the Science of Food and Agriculture, EarlyView.
Abstract INTRODUCTION Bromelain, a complex mixture of proteolytic enzymes primarily extracted from plants of the Bromeliaceae family, has gained prominence because of its broad industrial applicability, particularly in the food, pharmaceutical and cosmetic sectors.
Genésio José da Silva Neto, Tonny Cley Campos Leite, Mônica Tejo Cavalcanti, Geany Targino Sousa Pedrosa, Rerisson do Nascimento Alves, Amanda Reges de Sena, Mônica Correia Gonçalves   +6 more
wiley   +1 more source

Valor prognóstico das proteínas p53, C-erB-2 E Ki67 no carcinoma do ovário.

Acta Médica Portuguesa, 2001
The prognosis in ovarian carcinoma remains poor. We need to identify patients who are less likely to respond to treatment. In order to evaluate the prognostic value of C-erb-B2, p53 and Ki 67 expression and correlate these markers with classic prognostic
C Frutuoso, M R Silva, N Amaral, I Martins, C De Oliveira, H M De Oliveira   +5 more
doaj   +1 more source

The art of avoidance: bedsite use, antipredator strategies, and predation risk in white‐tailed deer fawns

The Journal of Wildlife Management, EarlyView.
Horizontal visibility, rather than concealment cover, drove fawn bedsite use and predation risk. Greater field of view decreased the odds of coyote predation, likely by facilitated by early detection. As fawns transitioned from hiders to followers, they shifted from using dense overstory concealment to more open overstory that favored improved escape ...
Tyler R. Obermoller, Eric S. Michel, Joseph K. Bump   +2 more
wiley   +1 more source

Key determinant of visitors' environmentally responsible behavior at Mlarangan Asri Beach Kulon Progo Regency, Indonesia [PDF]

E3S Web of Conferences
The sustainability of tourist attractions can be enhanced through Environmentally Responsible Behavior (ERB). This study aims to identify key factors that encourage visitor to ERB at Mlarangan Asri Beach and to explore the mechanisms of their impact.
Hasanah Erni Ummi, MZ Yumarlin, Lantarsih Retno, Ardi Iwan Aminto, Wahyudi Danang, Andika, Luthfiana Della Nanda   +6 more
doaj   +1 more source

7 T MRI Connectivity‐Guided Reprogramming Improves Deep Brain Stimulation Motor Outcome in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for Parkinson's disease (PD). Using 7‐Tesla (7 T) MRI connectivity analysis to visualize the patient‐specific STN motor subdivision, we hypothesize that reprogramming patients who are stimulated outside of this subdivision can improve their ...
Yarit Wiggerts, Annabel van der Weide, Rick Schuurman, Pepijn van den Munckhof, Rob MA de Bie, Martijn Beudel, Maarten Bot   +6 more
wiley   +1 more source