Results 51 to 60 of about 39,620 (261)

Cannabis‐Based Oil for Pain and Other Non‐Motor Symptoms in Parkinson's Disease: A Randomized Controlled Trial

Movement Disorders, EarlyView.
Abstract Background There is a lack of treatments for non‐motor symptoms (NMS) in Parkinson's disease (PD). Objective To assess the safety and effectiveness of an oral Cannabis sativa L. extract on pain and other NMS of PD. Methods This phase II, randomized, placebo‐controlled trial evaluated a formulation containing cannabidiol (CBD; 96 mg/ml) and Δ9 ...
Gabriel T. Kubota, Jacy B. Parmera, Matheus Deltreggia, Pedro N. Martins, Anna Letícia M. Alves, Ananda C.M. de Falcone, Ana Rosa Santana, Maria Alice P. Falcão, Mayara A. Dias, Larissa I. Moreira, Paulo C. de Fonseca Filho, Eberval G. Figueiredo, Egberto R. Barbosa, Rubens G. Cury, Daniel C. de Andrade   +14 more
wiley   +1 more source

Expression of p53, Ki-67 and c-erb B2 in growth hormone-and/or prolactin-secreting pituitary adenomas Expressão de p53, Ki-67 e c-erb B2 em adenomas hipofisários secretores de prolactina e/ou hormônio de crescimento

Arquivos de Neuro-Psiquiatria, 2006
The subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. In this study we investigated the presence of p53, Ki-67 and c-erb B2 in 38 pituitary adenomas with immunohistochemical positivity for GH and ...
Carlos Henrique A. Botelho, Albino Verçosa de Magalhães, Paulo Andrade de Mello, Fernando C. Schmitt, Luiz Augusto Casulari   +4 more
doaj   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Valor prognóstico da expressão por imuno-histoquímica do c-erb-2. Em doentes sob terapêutica adjuvante com Tamoxifeno por carcinoma primário da mama.

Acta Médica Portuguesa, 2004
The c-erb2 proto-oncogene is a member of the epidermal growth factor receptor family and has been associated with a more aggressive breast tumour biology and resistance to some types of treatments.To evaluate the prognostic value of c-erb-2 receptor ...
Andreia Antunes, Teresa Silva, Isabel Godinho, Natália Amaral, Calos Oliveira   +4 more
doaj   +1 more source

Hsp90 Inhibition on the Western Blot: N‐Terminal Versus C‐Terminal Inhibitors in Breast Cancer

Medicinal Research Reviews, EarlyView.
ABSTRACT Heat shock protein 90 (Hsp90) is an established and clinically validated anticancer target. By regulating the folding and maturation of diverse client proteins, it is indirectly involved in carcinogenesis. Key breast cancer oncogenic drivers, including estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2, are ...
Jaka Dernovšek, Jernej Cingl, Urša Pečar Fonović, Tihomir Tomašič   +3 more
wiley   +1 more source

Robust Performance Loss Rate Calculation for Photovoltaic Systems in High Latitude Locations

Progress in Photovoltaics: Research and Applications, EarlyView.
This work studies the best methods for performance loss rate (PLR) calculation in high latitude locations, characterized by strong seasonal variability. As the different methods can drastically affect the PLR value, an ensemble method consisting of multiple approaches was validated to be essential in identifying robust PLRs.
Lauri Karttunen, Väinö Anttalainen, Sami Jouttijärvi, Juha A. Karhu, Hugo Huerta, Samuli Ranta, Anders V. Lindfors, Kati Miettunen   +7 more
wiley   +1 more source

Expression of c-erb-B2 oncoprotein as a neoantigen strategy to repurpose anti-neu antibody therapy in a model of melanoma

Scientific Reports
In this study, we tested a novel approach of “repurposing” a biomarker typically associated with breast cancer for use in melanoma. HER2/neu is a well characterized biomarker in breast cancer for which effective anti-HER2/neu therapies are readily ...
Emmanuel M. Gabriel, Brian Necela, Deborah Bahr, Sneha Vivekanandhan, Barath Shreeder, Sanjay Bagaria, Keith L. Knutson   +6 more
doaj   +1 more source

Enhancing Tourists’ Environmentally Responsible Behavior at Zero-Waste Destinations: The Moderating Role of Environmental Facilitating Conditions

Journal of Consumer Sciences
Background: Environmental damage caused by visitor waste has become a critical issue, especially at zero-waste tourist sites. Therefore, understanding tourists’ Environmentally Responsible Behavior (ERB) is essential.
Nihayatu Aslamatis Solekah, Mardiana Mardiana, Hary Saputro Kurniawan   +2 more
doaj   +1 more source

The association between red blood cell distribution width‐to‐albumin ratio and risk of insomnia: A cross‐sectional analysis of National Health and Nutrition Examination Survey and Chinese clinical data

Sleep Research, EarlyView.
Abstract Background The red blood cell distribution width‐to‐albumin ratio (RAR) is a novel composite biomarker of inflammation and nutritional status, yet its association with insomnia and underlying mechanisms remain poorly understood. Objective To investigate the association between the RAR and insomnia in two independent cohorts, comprising a ...
Jingying Ma, Jue Hu, Lei Zhang, Yilin Meng, Fa Ye, Hailun Xia, Hongmin Zhang, Yonghua Zhang   +7 more
wiley   +1 more source

Ephrin B1 and B2 Mediate Cedar Virus Entry into Egyptian Fruit Bat Cells

Viruses
Cedar virus (CedV), closely related to the Hendra and Nipah viruses, is a novel Henipavirus that was originally isolated from flying foxes in Australia in 2012. Although its glycoprotein G exhibits relatively low sequence similarity with its counterparts
Lea Lenhard, Martin Müller, Sandra Diederich, Lisa Loerzer, Virginia Friedrichs, Bernd Köllner, Stefan Finke, Anca Dorhoi, Gang Pei   +8 more
doaj   +1 more source