Results 131 to 140 of about 576,050 (220)

Signaling through ERBB receptors: Multiple layers of diversity and control

, 2006
The four known ERBB receptors in humans are involved in a broad range of cellular responses, and their deregulation is a significant aspect in a large number of disease states.
Warren, Carmen M, Landgraf, Ralf
core   +1 more source

S100 Calcium‐Binding Protein 16 (S100A16) Promotes Hepatic Stellate Cell Activation Via Erb‐B2 Receptor Tyrosine Kinase 2 (ERBB2)‐mediated Glycolysis to Facilitate Liver Fibrosis

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Hepatic stellate cell (HSC) activation is a key mediator in hepatic fibrosis, with glycolysis serving a key regulatory function. S100 calcium‐binding protein 16 (S100A16) has been associated with various pathologies; however, its function and underlying mechanisms in liver fibrosis remains elusive.
Shiyu Ou, Xiaoling Tang, Juan Liu, Rong Ouyang, Shijiang Huang, Shuwen Weng, Jinping Qin, Dingheng Liang, Ling Du, Zhongzhuan Li   +9 more
wiley   +1 more source

Banxia Shumi Decoction Alleviates PCPA‐Induced Insomnia and Regulates ADAM10 Expression via Melatonin Signaling in Rats

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This study explored BXSMD's effect and mechanism on rat insomnia. Pentobarbital‐induced sleep tests showed that BXSMD shortened sleep latency and prolonged sleep duration compared with the model group. The mechanism relies on MT1/MT2 as core targets, which mediate the regulation of sleep‐related molecules (CLOCK, PER1, CaMKⅡ, p‐CREB/CREB, GABARAP, and ...
Baojun Guo, Yuqin Tang, Yongqiang Zhang, Yeke Wu, Ranran Gao   +4 more
wiley   +1 more source

The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease

Biomarker Insights, 2015
Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function.
Cassady E. Rupert, Kareen L.K. Coulombe
doaj   +1 more source

Emodin Suppresses the RAGE/ROCK1 Pathway to Modulate the Oligodendrocyte Lineage and Ameliorate Demyelination in Vascular Dementia Rats

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Emodin improves white matter remyelination and alleviates cognitive deficits through suppression of the RAGE/ROCK1 signaling pathway in VD rats. Mechanistically, it modulates the OL lineage by reducing the elevated proliferative response of OPCs while promoting their maturation and remyelination.
Xueqing Wang, Xiumei Dong, Cunbao He, Junjie Zhang, Wenming Ban, Guoqi Zhu, Jingji Wang, Yilan Zhen   +7 more
wiley   +1 more source

Input–output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic data

Molecular Systems Biology, 2009
The ErbB signaling pathways, which regulate diverse physiological responses such as cell survival, proliferation and motility, have been subjected to extensive molecular analysis.
William W Chen, Birgit Schoeberl, Paul J Jasper, Mario Niepel, Ulrik B Nielsen, Douglas A Lauffenburger, Peter K Sorger   +6 more
doaj   +1 more source

HPV‐Associated Adenosquamous Carcinoma of the Oropharynx With a PARD3B::ERBB4 Fusion

Genes, Chromosomes and Cancer, Volume 65, Issue 9, September 2026.
ABSTRACT Head and neck carcinomas can be diagnostically challenging because of their diverse histologic subtypes. We report a case of a 55‐year‐old male presenting with right‐sided cervical adenopathy, in whom imaging revealed a cystic lesion that was subsequently confirmed to be metastatic from a lesion at the base of the tongue.
Seddig Momenkhan, Jacques Blanc, Pierre Philouze, Jonathan Lopez, Francoise Descotes, Eudeline Alix, Camille Leonce, Ziyad Alsugair, Nazim Benzerdjeb   +8 more
wiley   +1 more source

ErbB signaling in brain injury regeneration: Pathway interactions and therapeutic potential

Neural Regeneration Research
The ErbB signaling network has recently emerged as a key modulator of central nervous system responses to injury. This review provides a comprehensive overview of ErbB receptors and their ligands, highlighting canonical and non-canonical signaling ...
Patricia Pérez-García, Nora Martínez-Gómez, Sonia Vázquez-de Górgolas, Andrea Chamorro-Francisco, Ricardo Pardillo-Díaz, Pedro Nunez-Abades, Carmen Castro, Livia Carrascal   +7 more
doaj   +1 more source

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

RNA‐Binding Proteins: Function, Biological Mechanisms, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
RNA‐binding proteins (RBPs) regulate RNA stability, localization, translation, and splicing through intrinsic binding domains and interactions with diverse cellular partners. Their competitive and cooperative networks shape disease‐related RNA programs, especially in cancer.
Ling Li, Xiuli Yan, Qing Ji, Hui Zhang
wiley   +1 more source