Results 141 to 150 of about 576,050 (220)

In Vivo Base Editing Partially Rescues Bone Dysplasia in a Mouse Model of Hutchinson‐Gilford Progeria Syndrome

Aging Cell, Volume 25, Issue 9, September 2026.
Hutchinson‐Gilford progeria syndrome (HGPS) is a premature aging disorder caused by a mutation in LMNA that produces the toxic progerin protein. In this study, an adenine base editor delivered via AAV9 achieved partial gene correction in HGPS mice when given at two weeks of age, partially rescuing bone structural and gene expression parameters and ...
Wayne A. Cabral, Caleb M. Grenko, Diana Yeritsyan, Indeevar Beeram, Shubham Laiwala, Lukas R. Johnson, Urraca L. Tavarez, Tingfen Yan, Stephen M. Wincovitch, Luke W. Koblan, Xin D. Gao, Meirui An, Narisu Narisu, Leslie G. Biesecker, David R. Liu, Ara Nazarian, Francis S. Collins, Michael R. Erdos   +17 more
wiley   +1 more source

Additional file 1: of Buformin inhibits the stemness of erbB-2-overexpressing breast cancer cells and premalignant mammary tissues of MMTV-erbB-2 transgenic mice

, 2017
Buformin does not upregulate AMPK activation in MMTV-erbB-2 mice. Representative images of p-AMPK immunostained mammary tissues from 18-week-old MMTV-erbB-2 mice that were fed control or buformin diets for 10 weeks are shown.
Amanda Parris (3744949), Ming Zhao (48501), Erin Howard (3744951), Zhikun Ma (309630), Xiaohe Yang (3744947), Qingxia Zhao (789655)   +5 more
core   +1 more source

Uterine Serous Carcinoma Arising From Endometrial Polyp: A Case Report

Gynecology Obstetrics & Reproductive Medicine, 2009
Serous carcinoma is the prototype of type II endometrial carcinoma. A 71-year-old woman who had history of smoking, diabetes mellitus and hypertension admitted to the hospital with postmenopausal uterine bleeding.
Sibel Bektaş, Burak Bahadır, Figen Barut, Ülkü Bayar, Şükrü Oğuz Özdamar   +4 more
doaj  

Discovery of Potent EGFR Inhibitors for Del19 and L858R/T790M Mutants Through Structure‐Based Virtual Screening and Biological Evaluation

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
XJ2‐2 overcomes NSCLC by blocking EGFR‑driven AKT/ERK cascades. ABSTRACT Epidermal growth factor receptor (EGFR) mutation‐mediated drug resistance represents a major clinical challenge in the treatment of non‐small cell lung cancer (NSCLC). In this study, the lead compound XJ2‐2 was identified through structure‐based virtual screening.
Ting Xu, Yuchen Zhao, Mengfei Chen, Lijuan Zuo, Hanshuang Cai, Yuguo Liu, Chuanfeng Liu, Jing Shi   +7 more
wiley   +1 more source

Targeting ErbB Receptors in High-Grade Glioma.

, 2011
High-grade gliomas, including glioblastoma, are among the most malignant and treatment-refractory human neoplasms. The tumors show high levels of resistance to conventional therapies (i.e.
Berezowska, S;Schlegel, J
core  

Spinal nerve injury causes upregulation of ErbB2 and ErbB3 receptors in rat dorsal root ganglia

Journal of Pain Research, 2013
Satoshi Mizobuchi,1* Hirotaka Kanzaki,1–3* Hiroki Omiya,1 Yoshikazu Matsuoka,1 Norihiko Obata,1 Ryuji Kaku,1 Hirochika Nakajima,1 Mamoru Ouchida,2 Kiyoshi Morita11Department of Anesthesiology and Resuscitology, 2Department of Molecular Genetics,
Mizobuchi S, Kanzaki H, Omiya H, Matsuoka Y, Obata N, Kaku R, Nakajima H, Ouchida M, Morita K   +8 more
doaj  

ERBB receptors in developing, dysplastic and malignant oral epithelia

, 2008
Some oral squamous cell carcinomas (OSCCs) overexpress epidermal growth factor receptor (EGFR) but little is known about the receptor system overall during oral carcinogenesis.
Myllykangas, S, P.R. Morgan, K.J. Jee, Miettinen, P J, Nagy, B, T. Soukka, Soukka, T, Morgan, P R, K. Heikinheimo, E.W. Odell, S. Myllykangas, Heikinheimo, K, Jee, K J, J. Rautava, Rautava, J, B. Nagy, Odell, E W, P.J. Miettinen   +17 more
core   +1 more source

ErbB-receptors expression and survival in breast carcinoma: a 15-year follow-up study

, 2006
Aberrant expression of the epidermal growth factor receptor family has been implicated in the pathogenesis and progression of breast cancer and associated with poor prognosis. To evaluate the prognostic impact of the ErbB receptors expression profile, we
SAIEVA C, PAGLIERANI M, OMEROVIC J, PALLI D, MARIANI COSTANTINI R, FALCHETTI M, MASALA G, LUPI R, BIANCHI S, MANCINI B, OTTINI, LAURA, NOVIELLO C, ALIMANDI, MAURIZIO, VEZZOSI V   +13 more
core   +1 more source

Roles of ErbB-3 and ErbB-4 in the Physiology and Pathology of the Mammary Gland

, 1997
ErbB-3 and ErbB-4 are the most recently discovered and least characterized of the class I tyrosine kinase receptors. ErbB-3 is noteworthy for its low tyrosine kinase activity, suggesting that it may function more as an adaptor in signaling than as a ...
Carraway, Kermit, Carraway III, Kermit, Carraway, Coralie   +2 more
core   +1 more source

Differential impact of the ERBB receptors EGFR and ERBB2 on the initiation of precursor lesions of pancreatic ductal adenocarcinoma. [PDF]

Sci Rep, 2020
Meyers N, Gérard C, Lemaigre FP, Jacquemin P.   +3 more
europepmc   +1 more source