Results 181 to 190 of about 576,050 (220)

The EGF/ErbB Receptor Family and Apoptosis

Growth Factors, 2002
The ErbB receptor family can activate a multitude of cell signaling pathways that involve many aspects of cellular function. The four members of the ErbB receptor family interact with diverse ligands and substrates, as well as with each other through cell surface heterodimerization.
Andrew J, Danielsen, Nita J, Maihle
openaire   +2 more sources

The ErbB Receptors and their Ligands in Cancer: An Overview

Current Drug Targets, 2005
This review article provides an overview on the most recent advances on the role of ErbB receptors and growth factors of the epidermal growth factor (EGF)-family of peptides in cancer pathogenesis and progression. The ErbB tyrosine kinases and the EGF-like peptides form a complex system. In fact, the interactions occurring between receptors and ligands
N, Normanno, C, Bianco, L, Strizzi, M, Mancino, M R, Maiello, A, De Luca, F, Caponigro, D S, Salomon   +7 more
openaire   +2 more sources

Expression of the ErbB Family of Receptors in Ovarian Cancer

Journal of the Society for Gynecologic Investigation, 1998
To characterize the relative levels of the ErbB family of receptors and their relationship to one another in ovarian cancer.A total of 17 serous cystadenocarcinomas were analyzed for epidermal growth factor receptor (EGF-R or ErbB-1) and ErbB-2, ErbB-3, and ErbB-4 receptor expression by Western blot analysis.
Craig Niederberger, Bert Scoccia
exaly   +3 more sources

ErbB Receptors and Cancer

2017
The ErbB receptor family, also known as the EGF receptor family or type I receptor family, includes the epidermal growth factor (EGF) receptor (EGFR) or ErbB1/Her1, ErbB2/Her2, ErbB3/Her3, and ErbB4/Her4. Among all RTKs, EGFR was the first RTK identified and the first one linked to cancer. Thus, EGFR has also been the most intensively studied among all
openaire   +2 more sources

ErbB-4: a receptor tyrosine kinase

Inflammation Research, 2002
ErbB-4 is a receptor tyrosine kinase that is activated by the binding of specific growth factors to its ectodomain. In addition to the initiation of signal transduction pathways that direct cell responses, such as proliferation or differentiation, this receptor is subject to ligand-dependent trafficking events.
W, Zhou, G, Carpenter
openaire   +2 more sources

Targeting ErbB receptor signaling: A pan-ErbB approach to cancer

Molecular Cancer Therapeutics, 2004
Abstract The ErbB receptors are localized to the cell membrane where they are activated by ligand to trigger a network of signaling pathways. In some cancer cells, dysregulation of ErbB-mediated signaling confers a growth advantage, resulting in cellular transformation and increased metastatic potential.
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Targeting ERBB Receptors in Cancer

2007
Tyrosine kinases are a large and diverse family of proteins found only in metazoans. The ERBB family, which encompasses subgroup I of the receptor tyrosine kinase (RTK) superfamily, has four members: epidermal growth factor receptor (EGFR)/ErbB1, ErbB2, ErbB3, and ErbB4.
openaire   +3 more sources

Cytohesins are cytoplasmic ErbB receptor activators.

Cell, 2010
Signaling by ErbB receptors requires the activation of their cytoplasmic kinase domains, which is initiated by ligand binding to the receptor ectodomains. Cytoplasmic factors contributing to the activation are unknown. Here we identify members of the cytohesin protein family as such factors.
Bill, A., Schmitz, A., Albertoni, B., Song, J., Heukamp, L., Walrafen, D., Thorwirth, F., Verveer, P., Zimmer, S., Meffert, L., Schreiber, A., Chatterjee, S., Thomas, R., Ullrich, R., Lang, T., Famulok, M.   +15 more
openaire   +4 more sources

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

Biochemistry, 1990
The erbB-1 and erbB-2 protooncogenes encode homologous membrane receptors that respectively bind epidermal growth factor (EGF) and a still incompletely characterized ligand. Binding of EGF to its receptor is known to increase tyrosine phosphorylation of the erbB-2/neu receptor in tumor cells. To investigate the mechanism of this transregulatory pathway,
R, Goldman, R B, Levy, E, Peles, Y, Yarden   +3 more
openaire   +2 more sources

Neuregulins and ErbB receptors in cultured neonatal astrocytes

Journal of Neuroscience Research, 1999
Neuregulins (NRGs) are a family of growth factors involved in signaling between neurons and glial cells of the peripheral and central nervous system. NRGs are synthesized and secreted by a number of cell types including Schwann cells, neurons, and oligodendrocytes.
A, Francis, T D, Raabe, D, Wen, G H, DeVries   +3 more
openaire   +2 more sources