Results 191 to 200 of about 576,050 (220)

ErbB receptors and the development of the nervous system

Experimental Cell Research, 2009
Tyrosine kinase receptors and their ligands allow communication between cells in the developing and adult organism. An extensive line of research has revealed that 'neuregulins', a family of EGF-like factors that signal via ErbB receptors, are used frequently for cell communication during nervous system development, and control a spectacular spectrum ...
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Neu/ErbB-2 Receptor

1995
Abstract The rodent 185 kD glycoprotein consists of 1260 amino acids (Bargmann et a/. 1986) (GenBank accession number X03662), whereas the human protein is 1255 amino acids long (Coussens eta/. 1985; Yamamoto et al. 1986) (GenBank accession number M11730).
Y Yarden, R B Levy
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Evolutionary Analysis of the ErbB Receptor and Ligand Families

Journal of Molecular Evolution, 2000
We have compared all available deduced protein sequences of the ErbB family of receptors and their ligands. Analysis of the aligned sequences of the receptors indicates that there are some differences in the receptors that are specific to invertebrates.
R A, Stein, J V, Staros
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ErbB receptors: new insights on mechanisms and biology

Trends in Cell Biology, 2006
The ErbB family of four receptor tyrosine kinases occupies a central role in a wide variety of biological processes from neuronal development to breast cancer. New information continues to expand their biologic significance and to unravel the molecular mechanisms that underlie the signaling capacity of these receptors.
Bryan, Linggi, Graham, Carpenter
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The EGFR/ERBB Receptor Family

2015
In metazoa, inductive cell-to-cell interactions play crucial roles, both in embryonic development and in homeostasis. Many such interactions are mediated by RTKs and their soluble or surface-bound ligand growth factors. Type 1 RTKs, also called the ERBB or HER family, comprises four proteins, which bind growth factors of the EGF and neuregulin families.
Fresia Pareja, Gur Pines, Yosef Yarden
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The ErbB Receptors as Targets for Breast Cancer Therapy

Journal of Mammary Gland Biology and Neoplasia, 1999
Breast carcinomas express high levels of ErbB receptors and their ligands, and their overexpression has been associated with a more aggressive clinical behavior. For these reasons therapies directed at these receptors have the potential to be useful anti-cancer treatments.
J, Albanell, J, Baselga
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Expression of erbB receptors mRNA in thyroid tissues

Biochimica et Biophysica Acta (BBA) - General Subjects, 2004
ErbB family members, such as epidermal growth factor receptor 1 (erbB1), erbB2, erbB3 and erbB4, are widely distributed in organ tissues, and these receptors are suspected tumorigenesis factors. We measured erbB mRNA in thyroid tissues of benign and malignant thyroid tumors or Graves' disease using Genescan.
Seiya, Kato, Takako, Kobayashi, Kouji, Yamada, Kazuhiro, Nishii, Hirohide, Sawada, Hiroshi, Ishiguro, Mitsuyasu, Itoh, Hiroomi, Funahashi, Akio, Nagasaka   +8 more
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Impact of ErbB Receptors and Anticancer Drugs against Breast Cancer: A Review

Current Pharmaceutical Biotechnology, 2022
Ankita Sahu, Manoj Kumar Yadav
exaly  

The erbB gene and the EGF receptor.

Cancer surveys, 1987
The epidermal growth factor (EGF) receptor is a plasma membrane glycoprotein. It contains four distinct segments: an N-terminal EGF binding domain which is exposed at the cell surface; a short transmembrane segment; a cytoplasmic domain with protein-tyrosine kinase activity; and a C-terminal regulatory segment.
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Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer

Biomedicines, 2023
Antonio Villalobo
exaly