Results 131 to 140 of about 54,427 (226)
NAD+‒circadian rhythm coupling in dementia
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract The circadian rhythm system and sleep coordinate whole‐body functions across the 24‐h cycle, yet these rhythms progressively deteriorate with neurodegenerative diseases, including dementia. Growing evidence indicates that nicotinamide adenine dinucleotide (NAD+) interacts with the circadian system through multiple molecular pathways and that ...
Shi‐qi Zhang +7 more
wiley +1 more source
Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma. [PDF]
Front Oncol, 2023 Breitenecker K +10 more
europepmc +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.Saikosaponin A from Radix Bupleuri inhibited colorectal cancer HCT116 cells with low toxicity. SSA induced S/G2‐M cell cycle arrest and triggered autophagy via mTOR inhibition. SSA suppressed metastasis by blocking PI3K/AKT signaling pathway. SSA significantly reduced tumor growth without apparent toxicity.
Xiu‐Xiu Zhang +7 more
wiley +1 more source
E3 ubiquitin ligases in ErbB receptor quantity control [PDF]
Seminars in Cell & Developmental Biology, 2010 Signaling through ErbB family growth factor receptor tyrosine kinases is necessary for the development and homeostasis of a wide variety of tissue types. However, the intensity of receptor-mediated cellular signaling must fall within a precise range; insufficient signaling can lead to developmental abnormalities or tissue atrophy, while over-signaling ...
openaire +2 more sources
The International Journal of Biological Markers, 2003 Background Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis.
I. García +5 more
doaj +1 more source
Folia Histochemica et Cytobiologica, 2010 The c-erbB-2 (HER-2/neu), EGF and EGFR (erbB-1) proteins, members of the epidermal growth factor receptor family, play a role in cell growth by binding to cell membrane receptors.
Katarzyna Guzinska-Ustymowicz +2 more
doaj +1 more source
ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author. [PDF]
J Mammary Gland Biol Neoplasia, 2023 Morato A, Accornero P, Hovey RC.
europepmc +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Understanding genetic alterations in lung cancer remains challenging due to tumor heterogeneity and malignancy. This study aimed to investigate somatic variations and immune‐related biomarkers in Chinese patients with NSCLC.
Xiumei Liu +6 more
wiley +1 more source
Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization. [PDF]
Mol Biol Res Commun, 2023 Mashayekh-Poul R +2 more
europepmc +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aim Janus kinases/signal transducers and activators of transcription (JAK/STAT) pathway is crucial for various stages of immunity, from innate to adaptive responses. Type 1 IFNs activate JAK/STAT pathway by binding to receptors on JAK, phosphorylating STAT and upregulating interferon‐stimulated genes (ISGs) leading to cytokines ...
Esimebia Adjovi Amegashie +7 more
wiley +1 more source