EGFR/ERBB receptors differentially modulate sebaceous lipogenesis
, 2015 The roles of the epidermal growth factor receptor (EGFR) in sebaceous glands remain poorly explored. We show that human sebocytes express EGFR and lower levels of ERBB2 and ERBB3, all receptors being downregulated after the induction of lipid synthesis ...
Ludovici, Matteo +7 more
core +1 more source
Membrane‐type I metalloproteinase (MT1‐MMP): A key modifier of extracellular matrix microenvironment
The FEBS Journal, Volume 293, Issue 13, Page 4085-4097, July 2026.MT1‐MMP: A cellular microenvironment modifier. MT1‐MMP is a major cellular microenvironment modifier, maintaining collagen homeostasis by degrading excess collagen (A), creating a migration path in motile cells such as cancer cells (B), modulating local microenvironmental signaling by cleaving transmembrane receptors (C), and destroying tissue ...
Yoshifumi Itoh, Masaki Inada
wiley +1 more source
Structural arrangement of the active back-to-back dimer in N-glycosylated ErbB receptors is regulated by heterodimerization. [PDF]
Mol Biol Res Commun, 2023 Mashayekh-Poul R +2 more
europepmc +1 more source
A Constellation of Fluorescent Biosensors to Illuminate the Galaxy of Protein Kinases
ChemBioChem, Volume 27, Issue 11, 15 June 2026.Protein kinases (PKs) are enzymes that catalyze phosphorylation of protein substrates involved in a wide variety of biological signalling pathways. This review describes the different families and mechanisms of action and regulation of protein kinases, together with the different classes of fluorescent biosensors that have been engineered and ...
Timothe Abbura, May C. Morris
wiley +1 more source
ERBB receptors in developing, dysplastic and malignant oral epithelia
, 2008 Some oral squamous cell carcinomas (OSCCs) overexpress epidermal growth factor receptor (EGFR) but little is known about the receptor system overall during oral carcinogenesis.
Myllykangas, S +17 more
core +1 more source
Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells. [PDF]
Cancers (Basel), 2022 Adediran S +9 more
europepmc +1 more source
Roles of ErbB-3 and ErbB-4 in the Physiology and Pathology of the Mammary Gland
, 1997 ErbB-3 and ErbB-4 are the most recently discovered and least characterized of the class I tyrosine kinase receptors. ErbB-3 is noteworthy for its low tyrosine kinase activity, suggesting that it may function more as an adaptor in signaling than as a ...
Carraway, Kermit +2 more
core +1 more source
ErbB-receptors expression and survival in breast carcinoma: a 15-year follow-up study
, 2006 Aberrant expression of the epidermal growth factor receptor family has been implicated in the pathogenesis and progression of breast cancer and associated with poor prognosis. To evaluate the prognostic impact of the ErbB receptors expression profile, we
SAIEVA C +13 more
core +1 more source
Binding specificities and affinities of egf domains for ErbB receptors
, 1999 ErbB receptor activation is a complex process and is dependent upon the type and number of receptors expressed on a given cell. Previous studies with defined combinations of ErbB receptors expressed in mammalian cells have helped elucidate specific ...
Sliwkowski, Mark X +5 more
core +1 more source
The Roles of Neuregulin-1 in Cardiac Development, Homeostasis, and Disease
Biomarker Insights, 2015 Neuregulin-1 (NRG-1) and its signaling receptors, erythroblastic leukemia viral oncogene homologs (ErbB) 2, 3, and 4, have been implicated in both cardiomyocyte development and disease, as well as in homeostatic cardiac function.
Cassady E. Rupert, Kareen L.K. Coulombe
doaj +1 more source