Results 101 to 110 of about 36,079 (213)
Thoracic Cancer, Volume 17, Issue 13, July 2026.MET amplification in EGFR‐mutated NSCLC alters the balance of EGFR/MET/ERBB3 receptor dimerization, leading to a shift toward MET‐dominant signaling dependence during acquired resistance to osimertinib. Resistant cells exhibit decreased EGFR homodimers and EGFR‐ERBB3 interactions together with increased MET‐containing dimers, resulting in substantial ...
Yuri Yagami +9 more
wiley +1 more source
Metastatic squamous cell carcinoma of the skin with clinical response to lapatinib
Experimental Hematology & Oncology, 2018 Background Lapatinib is a tyrosine kinase inhibitor that blocks the HER2 receptor and is typically used in the setting of metastatic breast cancer. Both ERBB2 (HER2) and ERBB3 (HER3) belong to the same family of receptor tyrosine kinases. Dimerization of
John D. Strickley +5 more
doaj +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren +8 more
wiley +1 more source
, 2016 Breast cancers are classified into categories according to specific criteria, such as histopathological type, tumour grade and more recently the gene expression signature.
Adriana Albini +6 more
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The Clinical Respiratory Journal, Volume 20, Issue 7, July 2026.ABSTRACT Background Pyroptosis is a recently identified form of programmed cell death that plays an important role in cancer initiation and progression. However, the function of pyroptosis in lung adenocarcinoma (LUAD) remains unclear. The study integrated proteomic and single‐cell RNA sequence (scRNA‐seq) data to investigate the potential role of ...
Tianchang Wei +7 more
wiley +1 more source
Synergism of the receptor tyrosine kinase Axl with ErbB receptors mediates resistance to regorafenib in hepatocellular carcinoma. [PDF]
Front Oncol, 2023 Breitenecker K +10 more
europepmc +1 more source
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, Volume 293, Issue 13, Page 3717-3757, July 2026.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
The International Journal of Biological Markers, 2003 Background Epidermal growth factor receptor (EGFR) and c-erbB-2 are membrane receptors expressed in a variety of solid human cancers and directly correlated with poor prognosis.
I. García +5 more
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Folia Histochemica et Cytobiologica, 2010 The c-erbB-2 (HER-2/neu), EGF and EGFR (erbB-1) proteins, members of the epidermal growth factor receptor family, play a role in cell growth by binding to cell membrane receptors.
Katarzyna Guzinska-Ustymowicz +2 more
doaj +1 more source
ERBB Receptors and Their Ligands in the Developing Mammary Glands of Different Species: Fifteen Characters in Search of an Author. [PDF]
J Mammary Gland Biol Neoplasia, 2023 Morato A, Accornero P, Hovey RC.
europepmc +1 more source