Results 81 to 90 of about 54,427 (226)
Frontiers in Cellular Neuroscience, 2018 Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder with no effective treatment currently available. Although the mechanisms of motoneuron (MN) death are still unclear, glutamate excitotoxicity and neuroinflammatory reaction ...
Guillem Mòdol-Caballero +7 more
doaj +1 more source
Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer. [PDF]
, 2019 Fluidity in cell fate or heterogeneity in cell identity is an interesting cell biological phenomenon, which at the same time poses a significant obstacle for cancer therapy.
Doh, Hanna +3 more
core +1 more source
Advanced Science, EarlyView.Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija +22 more
wiley +1 more source
The ErbB Receptors and Associated Key Signalling Proteins in Cancer
مجله كليه طب الكنديCancer is a disease of almost all multicellular organisms, in which communication between cells plays a crucial role in the life and development of that organism.
Ismail Al-Janabi
doaj +1 more source
The characterization, management, and future considerations for ErbB-family TKI-associated diarrhea. [PDF]
, 2019 PurposeDiarrhea is recognized as a common adverse event associated with tyrosine kinase inhibitors (TKIs), with those targeting the ErbB family of receptors being associated with the highest rate of diarrhea.MethodsThis paper reviews data on the ...
Bosserman, Linda +6 more
core
Transferrin-polycation conjugates as carriers for DNA uptake into cells. [PDF]
, 1990 We have developed a high-efficiency nucleic acid delivery system that uses receptor-mediated endocytosis to carry DNA macromolecules into cells. We accomplished this by conjugating the iron-transport protein transferrin to polycations that bind nucleic ...
Beug, Hartmut +4 more
core +1 more source
Advanced Science, EarlyView.We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin +17 more
wiley +1 more source
Advances in Preventive Therapy for Estrogen-Receptor-Negative Breast Cancer. [PDF]
, 2014 Preventing breast cancer is an effective strategy for reducing breast cancer deaths. The purpose of chemoprevention (also termed preventive therapy) is to reduce cancer incidence by use of natural, synthetic, or biological agents.
Brown, Powel H, Litzenburger, Beate C
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Advanced Science, EarlyView.In fibrotic distal lung regions, CD66c+ basal cells emerge as a pathological state. Using human distal lung organoids, this study identifies CD66c+ basal cells as a pro‐fibrotic state arising through transdifferentiation from secretory, AT2, and basal cells.
Kaijun Lin +13 more
wiley +1 more source
The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma [PDF]
Vojnosanitetski Pregled, 2006 Background/Aim. Most human cancers, including breast one, increase in frequency with aging. The aim of this study was to explore the hypothesis that aging also alters breast cancer biology. Methods.
Ivković-Kapicl Tatjana +4 more
doaj +1 more source