Results 71 to 80 of about 36,079 (213)

Total Syntheses of Agelamadin F and (±)‐Tauroacidin A, Enabled by NaClO2‐Mediated Coupling Reactions of Oroidin and Amines

Chemistry – A European Journal, EarlyView.
Total syntheses of agelamadin F and (±)‐tauroacidin A were achieved by sodium chlorite (NaClO2)‐mediated oxidative C─N coupling. Nine C15–N–amino acid‐substituted oroidin derivatives were successfully prepared to demonstrate the applicability and versatility of this oxidative coupling reaction.
Ryosuke Hirozumi, Yuta Kudo, Yuko Cho, Mari Yotsu‐Yamashita   +3 more
wiley   +1 more source

The ErbB Receptors and Associated Key Signalling Proteins in Cancer

مجله كليه طب الكندي
Cancer is a disease of almost all multicellular organisms, in which communication between cells plays a crucial role in the life and development of that organism.
Ismail Al-Janabi
doaj   +1 more source

Interaction of antibodies with ErbB receptor extracellular regions [PDF]

Experimental Cell Research, 2009
Antibodies to the extracellular region of the ErbB receptors have played key roles in the development of a mechanistic understanding of this family of receptor tyrosine kinases. An extensively studied class of such antibodies inhibits activation of ErbB receptors, and these antibodies have been the focus of intense development as anti-cancer agents. In
Karl R, Schmitz, Kathryn M, Ferguson
openaire   +2 more sources

Lipid Metabolism, Lipogenesis, and Resistance to Third Generation EGFR‐TKIs

Journal of Clinical Laboratory Analysis, EarlyView.
Cancer metabolism has emerged as a critical area of study in cancer research, offering insights into the complex mechanisms underlying tumor growth and development. Lipid metabolic reprogramming, especially the dynamic balance between fatty acid synthesis and fatty acid oxidation, plays significant roles in tumor progression. ABSTRACT Background Cancer
Wenhao Luo, Zun Wang, Guangzhi Ma, Wang Shen, Xiaobo Chen, Yida Liao   +5 more
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

The influence of aging on pathologic and immunobiologic parameters of invasive ductal breast carcinoma [PDF]

Vojnosanitetski Pregled, 2006
Background/Aim. Most human cancers, including breast one, increase in frequency with aging. The aim of this study was to explore the hypothesis that aging also alters breast cancer biology. Methods.
Ivković-Kapicl Tatjana, Knežević-Ušaj Slavica, Panjković Milana, Ninčić Dejan, Mastilović Katarina   +4 more
doaj   +1 more source

Effect of Salinity Stress on Gut–Brain–Gonad Axis in the Red‐Eared Slider (Trachemys scripta elegans)

Integrative Zoology, EarlyView.
The increase in salinity leads to changes in the gut microbiota and metabolites of Trachemys scripta elegans, affecting the synthesis and secretion of neurotransmitters or precursors, which can inhibit the secretion of reproductive hormones and affect the self‐renewal and differentiation process of spermatogonial stem cells.
Qiongyu Zhang, Na Li, Xue Tang, Hanru Chen, Meiling Hong, Li Ding   +5 more
wiley   +1 more source

Sistema Neuregulina1/ErbB: importância no controlo da função cardíaca.

Acta Médica Portuguesa, 2011
The family of Neuregulins (NRG), growth factors like epidermal growth factor, is known to induce growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells. This family comprises four members, being NRG1 the most largely studied,
Luisa Lopes-Conceição, Marina Dias-Neto, Ana Patrícia Fontes-Sousa, Pedro Mendes-Ferreira, Carolina Maia-Rocha, Tiago Henriques-Coelho, Gilles de Keulenaer, Adelino F Leite Moreira, Carmen Brás-Silva   +8 more
doaj   +1 more source

Endocytic downregulation of ErbB receptors: mechanisms and relevance in cancer

, 2008
Udgivelsesdato: 2008-MayErbB receptors (EGFR (ErbB1), ErbB2, ErbB3, and ErbB4) are important regulators of normal growth and differentiation, and they are involved in the pathogenesis of cancer.
Kirstine Roepstorff, Roepstorff, Kirstine, Bo van Deurs, Lerdrup, Mads, Mads Lerdrup, Lene Grøvdal, Grandal, Michael, Michael Grandal, Grøvdal, Lene, van Deurs, Bo   +9 more
core   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source