Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer [PDF]
Biomedicines, 2023 Overexpression and mutations of the epidermal growth factor receptor (EGFR/ErbB1/HER1) and other tyrosine kinase receptors of the ErbB family (ErbB2/HER2, ErbB3/HER3 and ErbB4/HER4) play an essential role in enhancing the proliferation, the migratory ...
Antonio Villalobo
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The Role of ErbB Receptors in Infection. [PDF]
Trends Microbiol, 2017 Members of the epidermal growth factor receptor family (ErbB family) possess a wide distribution and diverse functions ranging from cellular growth to migration and apoptosis. Though highly implicated in a variety of cancers, their involvement in infectious disease is less recognised. A growing body of evidence now highlights the importance of the ErbB
Ho J, Moyes DL, Tavassoli M, Naglik JR.
europepmc +8 more sources
Recent findings on the impact of ErbB receptors status on prognosis and therapy of head and neck squamous cell carcinoma [PDF]
Frontiers in Medicine, 2023 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer type, has often an aggressive course and is poorly responsive to current therapeutic approaches, so that 5-year survival rates for patients diagnosed with advanced disease is ...
Camilla Palumbo +13 more
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Combined treatment with inhibitors of ErbB Receptors and Hh signaling pathways is more effective than single treatment in reducing the growth of malignant mesothelioma both in vitro and in vivo [PDF]
Journal of Translational Medicine, 2022 Malignant mesothelioma (MM) is a rare orphan aggressive neoplasia with low survival rates. Among the other signaling pathways, ErbB receptors and Hh signaling are deregulated in MM.
Roberto Bei +17 more
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PLoS ONE, 2011 BackgroundBetacellulin (BTC), a member of the epidermal growth factor family, is known to play an important role in regulating growth and differentiation of pancreatic beta cells.
Yoon Sin Oh +4 more
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L1CAM binds ErbB receptors through Ig-like domains coupling cell adhesion and neuregulin signalling. [PDF]
PLoS ONE, 2012 During nervous system development different cell-to-cell communication mechanisms operate in parallel guiding migrating neurons and growing axons to generate complex arrays of neural circuits.
Emanuelle Donier +6 more
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Role of ErbB receptors in cancer cell migration and invasion [PDF]
Frontiers in Pharmacology, 2015 Growth factors mediate their diverse biologic responses (regulation of cellular proliferation, differentiation, migration and survival) by binding to and activating cell-surface receptors with intrinsic protein kinase activity named Receptor Tyrosine ...
Aline eAppert-Collin +4 more
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Profiling of ERBB receptors and downstream pathways reveals selectivity and hidden properties of ERBB4 antagonists [PDF]
iScienceSummary: ERBB receptor tyrosine kinases are involved in development and diseases like cancer, cardiovascular, neurodevelopmental, and mental disorders.
Lukša Popović +10 more
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Translocation of ErbB receptors into the nucleus [PDF]
Revista de Oncología, 2003 The work in the authors laboratory was financed by grants (to AV) from the Comisión Interministerial de Ciencia y Tecnología (SAF2002-03258), the Consejería de Educación de la Comunidad de Madrid (08.1/0027/2001-1), and the Agencia Española de Cooperación Internacional (2002CN0013).
Villalobo, Antonio +2 more
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ErbB receptors and signaling pathways in cancer
Current Opinion in Cell Biology, 2009 The ErbB receptor tyrosine kinases play important roles in normal physiology and in cancer. Epidermal growth factor receptor (EGFR) and ErbB2 in particular are mutated in many epithelial tumors, and clinical studies suggest that they play roles in cancer development and progression.
Hynes NE, MacDonald G
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