The International Journal of Biological Markers, 2012 Background The effects of progesterone are mediated by 2 progesterone receptors (PR), PR-A and PR-B. Recently, several lines of evidence have suggested that reduced PR expression may result from hyperactivity in the signaling cascade generated by the HER/
Clothilde Lindet +5 more
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Regulation of sebaceous gland homeostasis and sebum secretion by the ERBB receptor family [PDF]
iScienceSummary: ERBB receptors are underappreciated regulators of cellular processes in the sebaceous gland (SG). They control sebocyte proliferation, differentiation, and lipid production - mechanisms that are essential for SG homeostasis, sebum secretion, and
Theresa Hommel +2 more
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Does the ERBB/EGF Signaling Network Serve as a Nexus for Oncogenic Signals in Uveal Melanoma? [PDF]
BiomoleculesUveal melanomas (UMs) metastasize at a high frequency, and metastatic UMs are associated with very poor clinical outcomes. Consequently, there is considerable interest in the genetics and biochemistry of UM and in how these insights may lead to novel and
Niusha Raeesian, David J. Riese
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Progress in the Research and Targeted Therapy of ErbB/HER Receptors in Urothelial Bladder Cancer
Frontiers in Molecular Biosciences, 2021 Bladder cancer is a lethal malignancy and a majority of bladder cancer arise from urothelial cells. Infiltration and metastasis are barriers for the radical cystectomy to achieve favored outcome and are the main cause of death.
Dong Chen +3 more
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The ErbB Signaling Network and Its Potential Role in Endometrial Cancer
Epigenomes, 2023 Endometrial cancer (EC) is the second most common malignancy of the female reproductive system worldwide. The updated EC classification emphasizes the significant role of various signaling pathways such as PIK3CA-PIK3R1-PTEN and RTK/RAS/β-catenin in EC ...
Georgios Androutsopoulos +6 more
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Targeting erbB receptors [PDF]
Seminars in Cell and Developmental Biology, 2010 Hongtao Zhang +2 more
exaly +2 more sources
Frontiers in Cell and Developmental Biology, 2021 Betacellulin (BTC), an epidermal growth factor family, is known to promote β-cell regeneration. Recently, pancreatic α-cells have been highlighted as a source of new β-cells. We investigated the effect of BTC on α-cells.
Young-Sun Lee +7 more
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Coupled stochastic spatial and non-spatial simulations of ErbB1 signaling pathways demonstrate the importance of spatial organization in signal transduction. [PDF]
PLoS ONE, 2009 BACKGROUND: The ErbB family of receptors activates intracellular signaling pathways that control cellular proliferation, growth, differentiation and apoptosis.
Michelle N Costa +4 more
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ErbB polymorphisms: Insights and implications for response to targeted cancer therapeutics
Frontiers in Genetics, 2015 Advances in high-throughput genomic-scanning have expanded the repertory of genetic variations in DNA sequences encoding ErbB tyrosine kinase receptors in humans, including single nucleotide polymorphisms (SNPs), polymorphic repetitive elements ...
Moulay A Alaoui-Jamali +2 more
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Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network. [PDF]
, 2013 There is increasing evidence that opioid analgesics may interfere with tumour growth. It is currently thought that these effects are mediated by transactivation of receptor tyrosine kinase (RTK)-controlled ERK1/2 and Akt signalling.
Weingaertner, Inka Regine +5 more
core +1 more source