Results 31 to 40 of about 577,115 (171)
Biomolecules, 2023 Epidermal growth factor (EGF) and its homologs, such as neuregulins, bind to ErbB (Her) receptor kinases and regulate glial differentiation and dopaminergic/GABAergic maturation in the brain and are therefore implicated in schizophrenia neuropathology ...
Hidekazu Sotoyama +3 more
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Clinical relevance of soluble c-erbB-2 for patients with metastatic breast cancer predicting the response to second-line hormone or chemotherapy [PDF]
, 2002 Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent ...
Classen, S. +5 more
core +1 more source
Frontiers in Molecular Neuroscience, 2018 Increasing evidence demonstrates that the neurotrophic factor Neuregulin 1 (NRG1) and its receptors, ErbB tyrosine kinases, modulate midbrain dopamine (DA) transmission.
Ada Ledonne +2 more
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ON THE NOTION OF SYNERGY OF MONOCLONAL ANTIBODIES AS DRUGS [PDF]
Biotechnologia Acta, 2013 History of developing synergy between monoclonal antibodies, anti-tumor activity of monoclonal antibodies against tyrosine-kinases receptors EGFR/ErbB-1 and HER2/ErbB-2 as well as growth factor VEGF in various combinations are considered in the article ...
Michael Sela
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Biomolecules, 2022 The cross-talk between axon and glial cells during development and in adulthood is mediated by several molecules. Among them are neurotransmitters and their receptors, which are involved in the control of myelinating and non-myelinating glial cell ...
Roberta Piovesana +5 more
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A new model for ductal carcinoma in situ suggests strategies for treatment [PDF]
, 2002 Human ductal carcinoma in situ (DCIS) of the breast is now diagnosed quite frequently, due largely to the introduction of mammographic screening. It has been shown in a cell culture system that activation of c-erbB-2, but not the epidermal growth factor ...
Gullick, William J.
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ErbB2 signaling in breast cancer : the role of ErbB, Akt and ShcA phosphorylation [PDF]
, 2004 Breast cancer is the most common malignancy in women and is estimated to account for more than 200,000 new cancer cases in the United States in the year 2002. It now represents the second leading cause of death (40,000) from cancer in women.
Cicenas, Jonas
core +1 more source
Identification of nucleolin as new ErbB receptors- interacting protein.
PLoS ONE, 2008 BackgroundThe ErbB receptor tyrosine kinases are major contributors to malignant transformation. These receptors are frequently overexpressed in a variety of human carcinomas.
Ayelet Di Segni +2 more
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c-erbB-2 expression in benign and malignant breast disease. [PDF]
, 1988 An antibody, 21N, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunocytochemically in a retrospective study of formalin fixed paraffin embedded breast biopsies.
Gusterson, BA +17 more
core +1 more source
Insights into the evolution of the ErbB receptor family and their ligands from sequence analysis
BMC Evolutionary Biology, 2006 Background In the time since we presented the first molecular evolutionary study of the ErbB family of receptors and the EGF family of ligands, there has been a dramatic increase in genomic sequences available. We have utilized this greatly expanded data
Staros James V, Stein Richard A
doaj +1 more source