Results 161 to 170 of about 34,611 (189)

The status and role of ErbB receptors in human cancer

Experimental and Molecular Pathology, 2008
Changes in the expression of cellular receptors contribute to the progression of many types of solid tumors. In this review, we focus on the normal role of ErbB receptors as signal transducers and their contribution to carcinogenesis when there are abnormalities in ErbB signaling due to the overactivity of the receptors or the overexpression of ligands,
I, Uberall, Z, Kolár, R, Trojanec, J, Berkovcová, M, Hajdúch   +4 more
openaire   +2 more sources

ERBB receptors and cancer: the complexity of targeted inhibitors

Nature Reviews Cancer, 2005
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression.
Hynes NE, Lane HA
openaire   +3 more sources

Localization and modulation of ErbB receptor tyrosine kinases

Current Opinion in Cell Biology, 2001
The ErbB family of receptor tyrosine kinases serves as a model for understanding the propagation of growth factor signals across the plasma membrane and the interpretation of those signals into a cellular response. Recent studies point to a critical role for the accumulation of ErbBs at specific cell-surface locations in the fidelity of ErbB signaling.
K L, Carraway, C, Sweeney
openaire   +2 more sources

EGF/ErbB Receptor Family in Ovarian Cancer

2002
In summary, the EGF/ErbB family of receptor tyrosine kinases has been shown to play a key role in normal ovarian follicle development, and cell growth regulation of the ovarian surface epithelium. Disregulation of these normal growth regulatory pathways, including overexpression and/or mutation of EGFR/ErbB receptor family members, as well as elements ...
N J, Maihle, A T, Baron, B A, Barrette, C H, Boardman, T A, Christensen, E M, Cora, J M, Faupel-Badger, T, Greenwood, S C, Juneja, J M, Lafky, H, Lee, J L, Reiter, K C, Podratz   +12 more
openaire   +2 more sources

The erbB gene and the EGF receptor.

Cancer surveys, 1987
The epidermal growth factor (EGF) receptor is a plasma membrane glycoprotein. It contains four distinct segments: an N-terminal EGF binding domain which is exposed at the cell surface; a short transmembrane segment; a cytoplasmic domain with protein-tyrosine kinase activity; and a C-terminal regulatory segment.
openaire   +1 more source

Impact of ErbB Receptors and Anticancer Drugs against Breast Cancer: A Review

Current Pharmaceutical Biotechnology, 2022
Ankita Sahu, , Manoj Kumar Yadav
exaly  

Regulation of ErbB Receptors by the Ca2+ Sensor Protein Calmodulin in Cancer

Biomedicines, 2023
Antonio Villalobo, Villalobo Antonio
exaly  

ERBB RECEPTOR INHIBITORS

2022
YANG ZHENFAN, ZHANG XIAOLIN
openaire   +1 more source

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

EMBO Journal, 1997
Roger R Beerli, R R Beerli, Nancy E Hynes   +2 more
exaly  

The interface between ErbB and non-ErbB receptors in tumor invasion: clinical implications and opportunities for target discovery

Drug Resistance Updates, 2003
Moulay A Alaoui-Jamali
exaly