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Therapeutic Advances in Non-Small Cell Lung Cancer Harboring <i>EGFR</i> Exon 20 Insertion Mutations: From Molecular Biology to Targeted Therapy. [PDF]

Int J Mol Sci
Rosas D, Desai J, Raez L.
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ErbB receptors and signaling pathways in cancer

Current Opinion in Cell Biology, 2009
The ErbB receptor tyrosine kinases play important roles in normal physiology and in cancer. Epidermal growth factor receptor (EGFR) and ErbB2 in particular are mutated in many epithelial tumors, and clinical studies suggest that they play roles in cancer development and progression.
Nancy E, Hynes, Gwen, MacDonald
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ErbB receptors and the development of the nervous system

Experimental Cell Research, 2009
Tyrosine kinase receptors and their ligands allow communication between cells in the developing and adult organism. An extensive line of research has revealed that 'neuregulins', a family of EGF-like factors that signal via ErbB receptors, are used frequently for cell communication during nervous system development, and control a spectacular spectrum ...
Carmen Birchmeier
exaly   +3 more sources

ERBB receptors and cancer: the complexity of targeted inhibitors

Nature Reviews Cancer, 2005
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression.
Nancy E Hynes, Heidi A Lane, Hynes Nancy E   +2 more
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Immune responses to all ErbB family receptors detectable in serum of cancer patients

Oncogene, 1999
Employing NIH3T3 transfectants with individual human ErbB receptor coding sequences as recombinant antigen sources, we detected by immunoblot analysis specific immunoreactivity against all four ErbB receptors among 13 of 41 sera obtained from patients ...
Roberto Bei, Laura Masuelli, Matthias H Kraus   +2 more
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The ErbB receptors and their role in cancer progression

Experimental Cell Research, 2003
The involvement of the ErbB receptor tyrosine kinases in human cancer, as well as their essential role in a variety of physiological events during normal development, have motivated the interest in this receptor family. Approaches taken to block the activity of ErbB receptors in cancer cells have not only proven that they drive in vitro tumor cell ...
Holbro T, Civenni G, Hynes NE
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The EGF/ErbB Receptor Family and Apoptosis

Growth Factors, 2002
The ErbB receptor family can activate a multitude of cell signaling pathways that involve many aspects of cellular function. The four members of the ErbB receptor family interact with diverse ligands and substrates, as well as with each other through cell surface heterodimerization.
Andrew J, Danielsen, Nita J, Maihle
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ErbB receptors and their ligands in the breast

Expert Reviews in Molecular Medicine, 2006
ErbB receptor tyrosine kinases are membrane-bound receptors that possess intrinsic, ligand-activated, tyrosine kinase activity. Binding of growth factors to these receptors induces the formation of ErbB homo- and heterodimers and initiates a signalling cascade that traverses the cytoplasm to communicate with the nucleus and the cytoskeleton. The effect
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ErbB-4: a receptor tyrosine kinase

Inflammation Research, 2002
ErbB-4 is a receptor tyrosine kinase that is activated by the binding of specific growth factors to its ectodomain. In addition to the initiation of signal transduction pathways that direct cell responses, such as proliferation or differentiation, this receptor is subject to ligand-dependent trafficking events.
W, Zhou, G, Carpenter
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